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Peptide record

TPDB11092

Antibacterial Antifungal Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11092
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia AFP-GFuse Antifungipept CAFPdb DRAMP APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
SGTSEKERESGRLLGVVKRLIVCFRSPFP
Physicochemical Analysis
C143H239N43O41S1
ANDQHMWY
RS
3248.79
10.56
6
3
9
+3
8.59
-0.276
83.79
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
6
Residue Composition
number
0
A
4
R
0
N
0
D
1
C
3
E
0
Q
3
G
0
H
1
I
3
L
2
K
0
M
2
F
2
P
4
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 1 E: 3 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 2 M: 0 F: 2 P: 2 S: 4 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
29
C143H239N43O41S1
3248.79
10.56
+3
8.59
-0.276
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
48-51 µM

Target

Klebsiella oxytoca AB 2010143

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
gainst G- bacteria E. coli DH5alpha E. coli JM109 E. cloacae subsp. cloacae AB 2010162 K. oxytoca AB 2010143 (MIC 48-51 uM) P. putida P. fluorescens S. enterica AB 2010185 (MIC 23-25 uM) G+ bacteria B. magater
Evidence 2 Activity

Activity

MIC
Antibacterial
23-25 µM

Target

S. enterica AB 2010185

Source & Reference

dbAMP DRAMP

Other

bsp. cloacae AB 2010162 K. oxytoca AB 2010143 (MIC 48-51 uM) P. putida P. fluorescens S. enterica AB 2010185 (MIC 23-25 uM) G+ bacteria B. magaterium AB 90008 (MIC 11.8 um) S. aureus AB 94004 (MIC 23.6 uM) B. t
Evidence 3 Activity

Activity

MIC
Antibacterial
11.8 um

Target

B. magaterium AB 90008

Source & Reference

dbAMP DRAMP

Other

48-51 uM) P. putida P. fluorescens S. enterica AB 2010185 (MIC 23-25 uM) G+ bacteria B. magaterium AB 90008 (MIC 11.8 um) S. aureus AB 94004 (MIC 23.6 uM) B. thuringiensis AB 93100 (MIC 46.5 uM), and fungi C.
Evidence 4 Activity

Activity

MIC
Antibacterial
23.6 µM

Target

Staphylococcus aureus AB 94004

Source & Reference

dbAMP DRAMP

Other

S. enterica AB 2010185 (MIC 23-25 uM) G+ bacteria B. magaterium AB 90008 (MIC 11.8 um) S. aureus AB 94004 (MIC 23.6 uM) B. thuringiensis AB 93100 (MIC 46.5 uM), and fungi C. tropicalis AY 91009 (MIC 48.6 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
46.5 µM

Target

B. thuringiensis AB 93100

Source & Reference

dbAMP DRAMP

Other

uM) G+ bacteria B. magaterium AB 90008 (MIC 11.8 um) S. aureus AB 94004 (MIC 23.6 uM) B. thuringiensis AB 93100 (MIC 46.5 uM), and fungi C. tropicalis AY 91009 (MIC 48.6 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
48.6 µM

Target

C. tropicalis AY 91009

Source & Reference

dbAMP DRAMP

Other

um) S. aureus AB 94004 (MIC 23.6 uM) B. thuringiensis AB 93100 (MIC 46.5 uM), and fungi C. tropicalis AY 91009 (MIC 48.6 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
48-51 µM

Target

Klebsiella oxytoca AB 2010143

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
gainst G- bacteria E. coli DH5alpha E. coli JM109 E. cloacae subsp. cloacae AB 2010162 K. oxytoca AB 2010143 (MIC 48-51 uM) P. putida P. fluorescens S. enterica AB 2010185 (MIC 23-25 uM) G+ bacteria B. magater
Evidence 8 Activity

Activity

MIC
Antifungal
23-25 µM

Target

S. enterica AB 2010185

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

bsp. cloacae AB 2010162 K. oxytoca AB 2010143 (MIC 48-51 uM) P. putida P. fluorescens S. enterica AB 2010185 (MIC 23-25 uM) G+ bacteria B. magaterium AB 90008 (MIC 11.8 um) S. aureus AB 94004 (MIC 23.6 uM) B. t
Evidence 9 Activity

Activity

MIC
Antifungal
11.8 um

Target

B. magaterium AB 90008

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

48-51 uM) P. putida P. fluorescens S. enterica AB 2010185 (MIC 23-25 uM) G+ bacteria B. magaterium AB 90008 (MIC 11.8 um) S. aureus AB 94004 (MIC 23.6 uM) B. thuringiensis AB 93100 (MIC 46.5 uM), and fungi C.
Evidence 10 Activity

Activity

MIC
Antifungal
23.6 µM

Target

Staphylococcus aureus AB 94004

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. enterica AB 2010185 (MIC 23-25 uM) G+ bacteria B. magaterium AB 90008 (MIC 11.8 um) S. aureus AB 94004 (MIC 23.6 uM) B. thuringiensis AB 93100 (MIC 46.5 uM), and fungi C. tropicalis AY 91009 (MIC 48.6 uM).
Evidence 11 Activity

Activity

MIC
Antifungal
46.5 µM

Target

B. thuringiensis AB 93100

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM) G+ bacteria B. magaterium AB 90008 (MIC 11.8 um) S. aureus AB 94004 (MIC 23.6 uM) B. thuringiensis AB 93100 (MIC 46.5 uM), and fungi C. tropicalis AY 91009 (MIC 48.6 uM).
Evidence 12 Activity

Activity

MIC
Antifungal
48.6 µM

Target

C. tropicalis AY 91009

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

um) S. aureus AB 94004 (MIC 23.6 uM) B. thuringiensis AB 93100 (MIC 46.5 uM), and fungi C. tropicalis AY 91009 (MIC 48.6 uM).
Evidence 13 Activity

Activity

% Hemolysis
Hemolysis
5 35 95 100 %
[Ref.23000095]5% hemolytic activity at 0.8 µM, 35% hemolytic activity at 1.6 µM, 95% hemolytic activity at 3.2 µM, 100% hemolytic activity against human red blood cells.

Target

human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Peptides 38:389-394 (2012).

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

35% Hemolysis
Toxicity
1.6 µM
Hemolytic Cytotoxic
35% Hemolysis | 1.6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A novel class of antimicrobial peptides from the scorpion Heterometrus spinifer. | Peptides | 2012
Evidence 15 Activity

Activity

100% Hemolysis
Toxicity
6.4 µM
Hemolytic Cytotoxic
100% Hemolysis | 6.4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A novel class of antimicrobial peptides from the scorpion Heterometrus spinifer. | Peptides | 2012
Evidence 16 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23000095]5% hemolytic activity at 0.8 µM, 35% hemolytic activity at 1.6 µM, 95% hemolytic activity at 3.2 µM, 100% hemolytic activity against human red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides 38:389-394 (2012).
Evidence 17 Hemolysis

Activity

5 35 95 100 %
% Hemolysis
[Ref.23000095]5% hemolytic activity at 0.8 µM, 35% hemolytic activity at 1.6 µM, 95% hemolytic activity at 3.2 µM, 100% hemolytic activity against human red blood cells.
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Peptides 38:389-394 (2012).
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.