Back to search

Peptide record

TPDB11081

Antibacterial Antifungal Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11081
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KFKKLFKKLSPVIGKEFKRIVERIKRFLR
Physicochemical Analysis
C174H295N49O35
ANDCQHMTWY
K
3633.56
12.05
12
2
12
+10
8.80
-0.500
100.69
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
2
E
0
Q
1
G
0
H
3
I
3
L
8
K
0
M
4
F
1
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 8 M: 0 F: 4 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
29
C174H295N49O35
3633.56
12.05
+10
8.80
-0.500
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
20 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC 29213 (MIC 20 uM), E. faecalis ATCC 19433 (MIC 15 uM), S. epidermidis ATCC 12228 (MIC 10 uM), MRSA (MIC 5-1
Evidence 2 Activity

Activity

MIC
Antibacterial
15 µM

Target

Enterococcus faecalis ATCC 19433

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC 29213 (MIC 20 uM), E. faecalis ATCC 19433 (MIC 15 uM), S. epidermidis ATCC 12228 (MIC 10 uM), MRSA (MIC 5-10 uM), E. faecium VRE (MIC 5 uM), an
Evidence 3 Activity

Activity

MIC
Antibacterial
10 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC 29213 (MIC 20 uM), E. faecalis ATCC 19433 (MIC 15 uM), S. epidermidis ATCC 12228 (MIC 10 uM), MRSA (MIC 5-10 uM), E. faecium VRE (MIC 5 uM), and Gram- E. coli ATCC 25922 (MIC 10 uM),
Evidence 4 Activity

Activity

MIC
Antibacterial
5 µM

Target

E. faecium VRE

Source & Reference

dbAMP DRAMP

Other

ecalis ATCC 19433 (MIC 15 uM), S. epidermidis ATCC 12228 (MIC 10 uM), MRSA (MIC 5-10 uM), E. faecium VRE (MIC 5 uM), and Gram- E. coli ATCC 25922 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), A. bauma
Evidence 5 Activity

Activity

MIC
Antibacterial
10 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

dermidis ATCC 12228 (MIC 10 uM), MRSA (MIC 5-10 uM), E. faecium VRE (MIC 5 uM), and Gram- E. coli ATCC 25922 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), A. baumannii ATCC 19606 (MIC 10 uM), K. pneumoniae
Evidence 6 Activity

Activity

MIC
Antibacterial
20 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

MRSA (MIC 5-10 uM), E. faecium VRE (MIC 5 uM), and Gram- E. coli ATCC 25922 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), A. baumannii ATCC 19606 (MIC 10 uM), K. pneumoniae ATCC 13883 (MIC 2.5 uM). Antibiofilms
Evidence 7 Activity

Activity

MIC
Antibacterial
10 µM

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP DRAMP

Other

IC 5 uM), and Gram- E. coli ATCC 25922 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), A. baumannii ATCC 19606 (MIC 10 uM), K. pneumoniae ATCC 13883 (MIC 2.5 uM). Antibiofilms: S. aureus (MBEC 20 uM) and P. aerug
Evidence 8 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP DRAMP

Other

2 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), A. baumannii ATCC 19606 (MIC 10 uM), K. pneumoniae ATCC 13883 (MIC 2.5 uM). Antibiofilms: S. aureus (MBEC 20 uM) and P. aeruginosa (MBEC 25 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
20 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC 29213 (MIC 20 uM), E. faecalis ATCC 19433 (MIC 15 uM), S. epidermidis ATCC 12228 (MIC 10 uM), MRSA (MIC 5-1
Evidence 10 Activity

Activity

MIC
Antifungal
15 µM

Target

Enterococcus faecalis ATCC 19433

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against S. aureus ATCC 29213 (MIC 20 uM), E. faecalis ATCC 19433 (MIC 15 uM), S. epidermidis ATCC 12228 (MIC 10 uM), MRSA (MIC 5-10 uM), E. faecium VRE (MIC 5 uM), an
Evidence 11 Activity

Activity

MIC
Antifungal
10 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against S. aureus ATCC 29213 (MIC 20 uM), E. faecalis ATCC 19433 (MIC 15 uM), S. epidermidis ATCC 12228 (MIC 10 uM), MRSA (MIC 5-10 uM), E. faecium VRE (MIC 5 uM), and Gram- E. coli ATCC 25922 (MIC 10 uM),
Evidence 12 Activity

Activity

MIC
Antifungal
5 µM

Target

E. faecium VRE

Source & Reference

dbAMP DRAMP Antifungipept

Other

ecalis ATCC 19433 (MIC 15 uM), S. epidermidis ATCC 12228 (MIC 10 uM), MRSA (MIC 5-10 uM), E. faecium VRE (MIC 5 uM), and Gram- E. coli ATCC 25922 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), A. bauma
Evidence 13 Activity

Activity

MIC
Antifungal
10 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP Antifungipept

Other

dermidis ATCC 12228 (MIC 10 uM), MRSA (MIC 5-10 uM), E. faecium VRE (MIC 5 uM), and Gram- E. coli ATCC 25922 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), A. baumannii ATCC 19606 (MIC 10 uM), K. pneumoniae
Evidence 14 Activity

Activity

MIC
Antifungal
20 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP Antifungipept

Other

MRSA (MIC 5-10 uM), E. faecium VRE (MIC 5 uM), and Gram- E. coli ATCC 25922 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), A. baumannii ATCC 19606 (MIC 10 uM), K. pneumoniae ATCC 13883 (MIC 2.5 uM). Antibiofilms
Evidence 15 Activity

Activity

MIC
Antifungal
10 µM

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP DRAMP Antifungipept

Other

IC 5 uM), and Gram- E. coli ATCC 25922 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), A. baumannii ATCC 19606 (MIC 10 uM), K. pneumoniae ATCC 13883 (MIC 2.5 uM). Antibiofilms: S. aureus (MBEC 20 uM) and P. aerug
Evidence 16 Activity

Activity

MIC
Antifungal
2.5 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP DRAMP Antifungipept

Other

2 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 20 uM), A. baumannii ATCC 19606 (MIC 10 uM), K. pneumoniae ATCC 13883 (MIC 2.5 uM). Antibiofilms: S. aureus (MBEC 20 uM) and P. aeruginosa (MBEC 25 uM).
Evidence 17 Activity

Activity

0% Hemolysis
Toxicity
85 µM
Hemolytic Cytotoxic
0% Hemolysis | 85 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hybridization and antibiotic synergism as a tool for reducing the cytotoxicity of antimicrobial peptides. | Infect Drug Resist | 2018
Evidence 18 Activity

Activity

2.1% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
2.1% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hybridization and antibiotic synergism as a tool for reducing the cytotoxicity of antimicrobial peptides. | Infect Drug Resist | 2018
Evidence 19 Activity

Activity

IC50
Toxicity
61.9±0.18 µM
Cytotoxic
IC50 | 61.9±0.18 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Hybridization and antibiotic synergism as a tool for reducing the cytotoxicity of antimicrobial peptides. | Infect Drug Resist | 2018
Evidence 20 Activity

Activity

IC50
Toxicity
64.9±1.01 µM
Cytotoxic
IC50 | 64.9±1.01 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Hybridization and antibiotic synergism as a tool for reducing the cytotoxicity of antimicrobial peptides. | Infect Drug Resist | 2018
Evidence 21 Activity

Activity

IC50
Toxicity
61.9
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.29910626] 0% haemolysis at 5 µM, 0% haemolysis at 10 µM, 0% haemolysis at 25 µM, 0% haemolysis at 40 µM, 0% haemolysis at 55 µM, 0% haemolysis at 75 µM, 0% haemolysis at 80 µM, 2.1% haemolysis at 100 µM against human red blood cells | Cytotoxicity: [Ref.29910626] IC50 = 61.9±0.18 µM against HEK293.## IC50 = 64.9±1.01 µM against Vero.

Target

erythrocytes

Source & Reference

NA
DRAMP
Infect Drug Resist. 2018 Jun 1 11:835-847.