TPDB11078

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against Gram+ S. aureus ATCC25923 (MIC 20 uM), E. faecalis ATCC29212 (MIC 20 uM), S.aureus IS 10# (MIC >200 ug/ml), S.aureus IS 37# (MI

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against Gram+ S. aureus ATCC25923 (MIC 20 uM), E. faecalis ATCC29212 (MIC 20 uM), S.aureus IS 10# (MIC >200 ug/ml), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 13 µM

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

12 (MIC 20 uM), S.aureus IS 10# (MIC >200 ug/ml), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25922 (MIC 13 uM), E.coli (IS 37#) (MIC >200 ug/ml), E.coli IS 117# (MIC >200 ug/ml), E.coli IS 218# (MIC >

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >200 µg/mL

Target

Target Organism E.cloacae ATCC13047

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

37#) (MIC >200 ug/ml), E.coli IS 117# (MIC >200 ug/ml), E.coli IS 218# (MIC >200 ug/ml), E.cloacae ATCC13047 (MIC >200 ug/ml), K.pneumonia ATCC700603 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aerugin

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >200 µg/mL

Target

Target Organism K.pneumonia ATCC700603

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC >200 ug/ml), E.coli IS 218# (MIC >200 ug/ml), E.cloacae ATCC13047 (MIC >200 ug/ml), K.pneumonia ATCC700603 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aeruginosa ATCC27853 (33 uM), B. dysenteriae (MI

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism B. pyocyaneus CMCCB1010

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

00 ug/ml), E.cloacae ATCC13047 (MIC >200 ug/ml), K.pneumonia ATCC700603 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aeruginosa ATCC27853 (33 uM), B. dysenteriae (MIC 50 uM), P. aeruginosa IS 350# (MIC

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism B. dysenteriae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

3 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aeruginosa ATCC27853 (33 uM), B. dysenteriae (MIC 50 uM), P. aeruginosa IS 350# (MIC 50 uM), K. pneumonia IS 59# (MIC 50 uM), fungi C.albicans ATC

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >200 µg/mL

Target

Target Organism C.albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ae (MIC 50 uM), P. aeruginosa IS 350# (MIC 50 uM), K. pneumonia IS 59# (MIC 50 uM), fungi C.albicans ATCC2002 (MIC >200 ug/ml), C.albicans ATCC2002 (MIC >200 ug/ml), and C. albicans ATCC2002 (MIC MIC >200 ug/ml). Not

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >200 µg/mL

Target

Target Organism C.albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 50 uM), K. pneumonia IS 59# (MIC 50 uM), fungi C.albicans ATCC2002 (MIC >200 ug/ml), C.albicans ATCC2002 (MIC >200 ug/ml), and C. albicans ATCC2002 (MIC MIC >200 ug/ml). Note that the activity of the synthetic v

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against Gram+ S. aureus ATCC25923 (MIC 20 uM), E. faecalis ATCC29212 (MIC 20 uM), S.aureus IS 10# (MIC >200 ug/ml), S.aureus IS 37# (MI

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against Gram+ S. aureus ATCC25923 (MIC 20 uM), E. faecalis ATCC29212 (MIC 20 uM), S.aureus IS 10# (MIC >200 ug/ml), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 13 µM

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

12 (MIC 20 uM), S.aureus IS 10# (MIC >200 ug/ml), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25922 (MIC 13 uM), E.coli (IS 37#) (MIC >200 ug/ml), E.coli IS 117# (MIC >200 ug/ml), E.coli IS 218# (MIC >

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >200 µg/mL

Target

Target Organism E.cloacae ATCC13047

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

37#) (MIC >200 ug/ml), E.coli IS 117# (MIC >200 ug/ml), E.coli IS 218# (MIC >200 ug/ml), E.cloacae ATCC13047 (MIC >200 ug/ml), K.pneumonia ATCC700603 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aerugin

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >200 µg/mL

Target

Target Organism K.pneumonia ATCC700603

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC >200 ug/ml), E.coli IS 218# (MIC >200 ug/ml), E.cloacae ATCC13047 (MIC >200 ug/ml), K.pneumonia ATCC700603 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aeruginosa ATCC27853 (33 uM), B. dysenteriae (MI

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20 µM

Target

Target Organism B. pyocyaneus CMCCB1010

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

00 ug/ml), E.cloacae ATCC13047 (MIC >200 ug/ml), K.pneumonia ATCC700603 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aeruginosa ATCC27853 (33 uM), B. dysenteriae (MIC 50 uM), P. aeruginosa IS 350# (MIC

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µM

Target

Target Organism B. dysenteriae

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

3 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aeruginosa ATCC27853 (33 uM), B. dysenteriae (MIC 50 uM), P. aeruginosa IS 350# (MIC 50 uM), K. pneumonia IS 59# (MIC 50 uM), fungi C.albicans ATC

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >200 µg/mL

Target

Target Organism C.albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ae (MIC 50 uM), P. aeruginosa IS 350# (MIC 50 uM), K. pneumonia IS 59# (MIC 50 uM), fungi C.albicans ATCC2002 (MIC >200 ug/ml), C.albicans ATCC2002 (MIC >200 ug/ml), and C. albicans ATCC2002 (MIC MIC >200 ug/ml). Not

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >200 µg/mL

Target

Target Organism C.albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 50 uM), K. pneumonia IS 59# (MIC 50 uM), fungi C.albicans ATCC2002 (MIC >200 ug/ml), C.albicans ATCC2002 (MIC >200 ug/ml), and C. albicans ATCC2002 (MIC MIC >200 ug/ml). Note that the activity of the synthetic v

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 20 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against Gram+ S. aureus ATCC25923 (MIC 20 uM), E. faecalis ATCC29212 (MIC 20 uM), S.aureus IS 10# (MIC >200 ug/ml), S.aureus IS 37# (MI

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 20 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Gram+ S. aureus ATCC25923 (MIC 20 uM), E. faecalis ATCC29212 (MIC 20 uM), S.aureus IS 10# (MIC >200 ug/ml), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 13 µM

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source DRAMP

Other

Evidence Text

12 (MIC 20 uM), S.aureus IS 10# (MIC >200 ug/ml), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25922 (MIC 13 uM), E.coli (IS 37#) (MIC >200 ug/ml), E.coli IS 117# (MIC >200 ug/ml), E.coli IS 218# (MIC >

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >200 µg/mL

Target

Target Organism E.cloacae ATCC13047

Source & Reference

Database Source DRAMP

Other

Evidence Text

37#) (MIC >200 ug/ml), E.coli IS 117# (MIC >200 ug/ml), E.coli IS 218# (MIC >200 ug/ml), E.cloacae ATCC13047 (MIC >200 ug/ml), K.pneumonia ATCC700603 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aerugin

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >200 µg/mL

Target

Target Organism K.pneumonia ATCC700603

Source & Reference

Database Source DRAMP

Other

Evidence Text

(MIC >200 ug/ml), E.coli IS 218# (MIC >200 ug/ml), E.cloacae ATCC13047 (MIC >200 ug/ml), K.pneumonia ATCC700603 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aeruginosa ATCC27853 (33 uM), B. dysenteriae (MI

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 20 µM

Target

Target Organism B. pyocyaneus CMCCB1010

Source & Reference

Database Source DRAMP

Other

Evidence Text

00 ug/ml), E.cloacae ATCC13047 (MIC >200 ug/ml), K.pneumonia ATCC700603 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aeruginosa ATCC27853 (33 uM), B. dysenteriae (MIC 50 uM), P. aeruginosa IS 350# (MIC

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µM

Target

Target Organism B. dysenteriae

Source & Reference

Database Source DRAMP

Other

Evidence Text

3 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aeruginosa ATCC27853 (33 uM), B. dysenteriae (MIC 50 uM), P. aeruginosa IS 350# (MIC 50 uM), K. pneumonia IS 59# (MIC 50 uM), fungi C.albicans ATC

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >200 µg/mL

Target

Target Organism C.albicans ATCC2002

Source & Reference

Database Source DRAMP

Other

Evidence Text

ae (MIC 50 uM), P. aeruginosa IS 350# (MIC 50 uM), K. pneumonia IS 59# (MIC 50 uM), fungi C.albicans ATCC2002 (MIC >200 ug/ml), C.albicans ATCC2002 (MIC >200 ug/ml), and C. albicans ATCC2002 (MIC MIC >200 ug/ml). Not

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >200 µg/mL

Target

Target Organism C.albicans ATCC2002

Source & Reference

Database Source DRAMP

Other

Evidence Text

(MIC 50 uM), K. pneumonia IS 59# (MIC 50 uM), fungi C.albicans ATCC2002 (MIC >200 ug/ml), C.albicans ATCC2002 (MIC >200 ug/ml), and C. albicans ATCC2002 (MIC MIC >200 ug/ml). Note that the activity of the synthetic v

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 20 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against Gram+ S. aureus ATCC25923 (MIC 20 uM), E. faecalis ATCC29212 (MIC 20 uM), S.aureus IS 10# (MIC >200 ug/ml), S.aureus IS 37# (MI

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 20 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Gram+ S. aureus ATCC25923 (MIC 20 uM), E. faecalis ATCC29212 (MIC 20 uM), S.aureus IS 10# (MIC >200 ug/ml), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 13 µM

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source DRAMP

Other

Evidence Text

12 (MIC 20 uM), S.aureus IS 10# (MIC >200 ug/ml), S.aureus IS 37# (MIC >200 ug/ml), Gram- E. coli ATCC25922 (MIC 13 uM), E.coli (IS 37#) (MIC >200 ug/ml), E.coli IS 117# (MIC >200 ug/ml), E.coli IS 218# (MIC >

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >200 µg/mL

Target

Target Organism E.cloacae ATCC13047

Source & Reference

Database Source DRAMP

Other

Evidence Text

37#) (MIC >200 ug/ml), E.coli IS 117# (MIC >200 ug/ml), E.coli IS 218# (MIC >200 ug/ml), E.cloacae ATCC13047 (MIC >200 ug/ml), K.pneumonia ATCC700603 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aerugin

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >200 µg/mL

Target

Target Organism K.pneumonia ATCC700603

Source & Reference

Database Source DRAMP

Other

Evidence Text

(MIC >200 ug/ml), E.coli IS 218# (MIC >200 ug/ml), E.cloacae ATCC13047 (MIC >200 ug/ml), K.pneumonia ATCC700603 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aeruginosa ATCC27853 (33 uM), B. dysenteriae (MI

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 20 µM

Target

Target Organism B. pyocyaneus CMCCB1010

Source & Reference

Database Source DRAMP

Other

Evidence Text

00 ug/ml), E.cloacae ATCC13047 (MIC >200 ug/ml), K.pneumonia ATCC700603 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aeruginosa ATCC27853 (33 uM), B. dysenteriae (MIC 50 uM), P. aeruginosa IS 350# (MIC

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 50 µM

Target

Target Organism B. dysenteriae

Source & Reference

Database Source DRAMP

Other

Evidence Text

3 (MIC >200 ug/ml), B. pyocyaneus CMCCB1010 (MIC 20 uM), P. aeruginosa ATCC27853 (33 uM), B. dysenteriae (MIC 50 uM), P. aeruginosa IS 350# (MIC 50 uM), K. pneumonia IS 59# (MIC 50 uM), fungi C.albicans ATC

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >200 µg/mL

Target

Target Organism C.albicans ATCC2002

Source & Reference

Database Source DRAMP

Other

Evidence Text

ae (MIC 50 uM), P. aeruginosa IS 350# (MIC 50 uM), K. pneumonia IS 59# (MIC 50 uM), fungi C.albicans ATCC2002 (MIC >200 ug/ml), C.albicans ATCC2002 (MIC >200 ug/ml), and C. albicans ATCC2002 (MIC MIC >200 ug/ml). Not

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >200 µg/mL

Target

Target Organism C.albicans ATCC2002

Source & Reference

Database Source DRAMP

Other

Evidence Text

(MIC 50 uM), K. pneumonia IS 59# (MIC 50 uM), fungi C.albicans ATCC2002 (MIC >200 ug/ml), C.albicans ATCC2002 (MIC >200 ug/ml), and C. albicans ATCC2002 (MIC MIC >200 ug/ml). Note that the activity of the synthetic v

Evidence 37 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Hemolysis

Activity Measurement 135 µM

Hemolysis Raw

[Ref:21816202] IC50=135 µM against human and rabbit erythrocytes

Target

RBC Target human

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

Biochimie. 2012 Feb 94(2):328-334.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 38 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 135 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 135 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis. | Biochimie | 2012

Evidence 39 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 135 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 135 | µM | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis. | Biochimie | 2012

Evidence 40 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 135 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: [Ref:21816202] IC50=135 µM against human and rabbit erythrocytes | Cytotoxicity: [Ref.21816202] Cytotoxicity: the K562 (IC50=58µM) and HT29 mammalian cell lines(IC50=57µM).

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biochimie. 2012 Feb 94(2):328-334.

Evidence 41 Hemolysis

Activity

Activity Measurement 135 µM

Activity Endpoint IC50

Hemolysis Raw

[Ref:21816202] IC50=135 µM against human and rabbit erythrocytes

Detail Source Activity Hemolysis

Target

RBC Target human

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Reference

Biochimie. 2012 Feb 94(2):328-334.

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.