Back to search

Peptide record

TPDB11071

Antibacterial Antifungal Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11071
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP PD_Hemolysis
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
LKKLCARLKKLCARLKKLCARLKKLCAR
Physicochemical Analysis
C144H274N48O29S4
NDEQGHIMFPSTWYV
LK
3270.30
11.24
12
0
12
+12
5.04
-0.057
125.71
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
250
7.64
4
Residue Composition
number
4
A
4
R
0
N
0
D
4
C
0
E
0
Q
0
G
0
H
0
I
8
L
8
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 4 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 8 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
28
C144H274N48O29S4
3270.30
11.24
+12
5.04
-0.057
Evidence Records 4 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
10% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure-Function Relationships to Combat Drug-Resistant Fungi and Biofilms | ACS Appl Mater Interfaces | 2020
Evidence 2 Activity

Activity

70% Killing
Toxicity
128 µM
Cytotoxic
70% Killing | 128 | µM | target cell: Mouse primary corneal epithelial cells (MPCE)

Target

Mouse primary corneal epithelial cells (MPCE)

Source & Reference

NA
DBAASP
Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure-Function Relationships to Combat Drug-Resistant Fungi and Biofilms | ACS Appl Mater Interfaces | 2020
Evidence 3 Activity

Activity

20% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
20% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure-Function Relationships to Combat Drug-Resistant Fungi and Biofilms | ACS Appl Mater Interfaces | 2020
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis