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Peptide record

TPDB11071

Antibacterial Antifungal Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11071
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP PD_Hemolysis
standard
No
A 28-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
LKKLCARLKKLCARLKKLCARLKKLCAR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C144H274N48O29S4
NDEQGHIMFPSTWYV
LK
3270.30
11.24
12
0
12
+12
1.87
-0.057
125.71
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
250
0.08
4
Residue Composition
number
4
A
4
R
0
N
0
D
4
C
0
E
0
Q
0
G
0
H
0
I
8
L
8
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 4 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 8 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
28 reviewed residue count
C144H274N48O29S4 sequence-only estimate (linear, free termini)
3270.30 sequence-only estimate (linear, free termini)
11.24 sequence-only estimate (linear, free termini)
+12 sequence-only estimate (linear, free termini)
1.87 sequence-only estimate (linear, free termini)
-0.057 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
10% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure-Function Relationships to Combat Drug-Resistant Fungi and Biofilms | ACS Appl Mater Interfaces | 2020
Evidence 2 Activity

Activity

70% Killing
Toxicity
128 µM
Cytotoxic
70% Killing | 128 | µM | target cell: Mouse primary corneal epithelial cells (MPCE)

Target

Mouse primary corneal epithelial cells (MPCE)

Source & Reference

NA
DBAASP
Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure-Function Relationships to Combat Drug-Resistant Fungi and Biofilms | ACS Appl Mater Interfaces | 2020
Evidence 3 Activity

Activity

20% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
20% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure-Function Relationships to Combat Drug-Resistant Fungi and Biofilms | ACS Appl Mater Interfaces | 2020
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis