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Peptide record

TPDB11070

Antibacterial Anticancer Antifungal Antiviral Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11070
Antibacterial Anticancer Antifungal Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept AI4AVP DRAVP 2.0 ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
WYQLIRTFGNLIHQKYRKLLEAYRKLRD
Physicochemical Analysis
C169H265N49O40
CMPSV
L
3623.27
10.62
8
2
13
+5
2.76
-0.846
101.07
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
9970
275.17
7
Residue Composition
number
1
A
4
R
1
N
1
D
0
C
1
E
2
Q
1
G
1
H
2
I
5
L
3
K
0
M
1
F
0
P
0
S
1
T
1
W
3
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 1 D: 1 C: 0 E: 1 Q: 2 G: 1 H: 1 I: 2 L: 5 K: 3 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 3 V: 0
Chemical Descriptors
28
C169H265N49O40
3623.27
10.62
+5
2.76
-0.846
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.41 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

NA

Other

MIC assays using gram-positive strains, S. aureus ATCC 6538 (MIC 0.41 uM), Bacillus cereus ATCC 10876 (MIC 1.66 uM), and E. faecalis ATCC 29212 (MIC 0.55 uM), and
Evidence 2 Activity

Activity

MIC
Antibacterial
0.55 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

NA

Other

strains, S. aureus ATCC 6538 (MIC 0.41 uM), Bacillus cereus ATCC 10876 (MIC 1.66 uM), and E. faecalis ATCC 29212 (MIC 0.55 uM), and 3 gram-negative strains, E. coli ATCC 25922 (MIC 1.38 uM). Also: inhibit West Nile v
Evidence 3 Activity

Activity

MIC
Antibacterial
1.38 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

876 (MIC 1.66 uM), and E. faecalis ATCC 29212 (MIC 0.55 uM), and 3 gram-negative strains, E. coli ATCC 25922 (MIC 1.38 uM). Also: inhibit West Nile virus (WNV) replication in primary keratinocytes.
Evidence 4 Activity

Activity

MIC
Antifungal
0.41 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

Antifungipept

Other

MIC assays using gram-positive strains, S. aureus ATCC 6538 (MIC 0.41 uM), Bacillus cereus ATCC 10876 (MIC 1.66 uM), and E. faecalis ATCC 29212 (MIC 0.55 uM), and
Evidence 5 Activity

Activity

MIC
Antifungal
0.55 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

Antifungipept

Other

strains, S. aureus ATCC 6538 (MIC 0.41 uM), Bacillus cereus ATCC 10876 (MIC 1.66 uM), and E. faecalis ATCC 29212 (MIC 0.55 uM), and 3 gram-negative strains, E. coli ATCC 25922 (MIC 1.38 uM). Also: inhibit West Nile v
Evidence 6 Activity

Activity

MIC
Antifungal
1.38 µM

Target

Escherichia coli ATCC 25922

Source & Reference

Antifungipept

Other

876 (MIC 1.66 uM), and E. faecalis ATCC 29212 (MIC 0.55 uM), and 3 gram-negative strains, E. coli ATCC 25922 (MIC 1.38 uM). Also: inhibit West Nile virus (WNV) replication in primary keratinocytes.
Evidence 7 Activity

Activity

MIC
Antiviral
0.41 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

DRAVP 2.0

Other

MIC assays using gram-positive strains, S. aureus ATCC 6538 (MIC 0.41 uM), Bacillus cereus ATCC 10876 (MIC 1.66 uM), and E. faecalis ATCC 29212 (MIC 0.55 uM), and
Evidence 8 Activity

Activity

MIC
Antiviral
0.55 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

DRAVP 2.0

Other

strains, S. aureus ATCC 6538 (MIC 0.41 uM), Bacillus cereus ATCC 10876 (MIC 1.66 uM), and E. faecalis ATCC 29212 (MIC 0.55 uM), and 3 gram-negative strains, E. coli ATCC 25922 (MIC 1.38 uM). Also: inhibit West Nile v
Evidence 9 Activity

Activity

MIC
Antiviral
1.38 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAVP 2.0

Other

876 (MIC 1.66 uM), and E. faecalis ATCC 29212 (MIC 0.55 uM), and 3 gram-negative strains, E. coli ATCC 25922 (MIC 1.38 uM). Also: inhibit West Nile virus (WNV) replication in primary keratinocytes.
Evidence 10 Activity

Activity

32.6% Cytotoxicity
Toxicity
16 µg/mL
Cytotoxic
32.6% Cytotoxicity | 16 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 11 Activity

Activity

52.2% Cytotoxicity
Toxicity
32 µg/mL
Cytotoxic
52.2% Cytotoxicity | 32 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 12 Activity

Activity

65% Cytotoxicity
Toxicity
64 µg/mL
Cytotoxic
65% Cytotoxicity | 64 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 13 Activity

Activity

4% Cytotoxicity
Toxicity
16 µg/mL
Cytotoxic
4% Cytotoxicity | 16 | µg/mL | target cell: Human Primary Epidermal Keratinocytes (HEK)

Target

Human Primary Epidermal Keratinocytes (HEK)

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 14 Activity

Activity

21% Cytotoxicity
Toxicity
32 µg/mL
Cytotoxic
21% Cytotoxicity | 32 | µg/mL | target cell: Human Primary Epidermal Keratinocytes (HEK)

Target

Human Primary Epidermal Keratinocytes (HEK)

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 15 Activity

Activity

51% Cytotoxicity
Toxicity
64 µg/mL
Cytotoxic
51% Cytotoxicity | 64 | µg/mL | target cell: Human Primary Epidermal Keratinocytes (HEK)

Target

Human Primary Epidermal Keratinocytes (HEK)

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 16 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Immunol. 2020 Mar 3 11:348.