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Peptide record

TPDB11068

Antibacterial Antifungal Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11068
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
LKKLACRLKKLACRLKKLACRLKKLACR
Physicochemical Analysis
C144H274N48O29S4
NDEQGHIMFPSTWYV
LK
3270.30
11.24
12
0
12
+12
5.04
-0.057
125.71
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
250
7.64
4
Residue Composition
number
4
A
4
R
0
N
0
D
4
C
0
E
0
Q
0
G
0
H
0
I
8
L
8
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 4 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 8 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
28
C144H274N48O29S4
3270.30
11.24
+12
5.04
-0.057
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
10% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure-Function Relationships to Combat Drug-Resistant Fungi and Biofilms | ACS Appl Mater Interfaces | 2020
Evidence 2 Activity

Activity

65% Killing
Toxicity
128 µM
Cytotoxic
65% Killing | 128 | µM | target cell: Mouse primary corneal epithelial cells (MPCE)

Target

Mouse primary corneal epithelial cells (MPCE)

Source & Reference

NA
DBAASP
Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure-Function Relationships to Combat Drug-Resistant Fungi and Biofilms | ACS Appl Mater Interfaces | 2020
Evidence 3 Activity

Activity

15% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
15% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure-Function Relationships to Combat Drug-Resistant Fungi and Biofilms | ACS Appl Mater Interfaces | 2020