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Peptide record

TPDB11067

Antibacterial Antifungal Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11067
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 28-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KYEITTIHNLFRKLTHRLFRRNFGYTLR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C166H261N51O39
ADCQMPSWV
R
3595.22
11.86
9
1
11
+6
3.08
-0.729
83.57
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
2980
0.83
8
Residue Composition
number
0
A
5
R
2
N
0
D
0
C
1
E
0
Q
1
G
2
H
2
I
4
L
2
K
0
M
3
F
0
P
0
S
4
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 2 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 2 I: 2 L: 4 K: 2 M: 0 F: 3 P: 0 S: 0 T: 4 W: 0 Y: 2 V: 0
Chemical Descriptors
28 reviewed residue count
C166H261N51O39 sequence-only estimate (linear, free termini)
3595.22 sequence-only estimate (linear, free termini)
11.86 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
3.08 sequence-only estimate (linear, free termini)
-0.729 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
60 µM
Hemolytic Cytotoxic
<5% Hemolysis | 60 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A peptide of heparin cofactor II inhibits endotoxin-mediated shock and invasive Pseudomonas aeruginosa infection. | PLoS One | 2014
Evidence 2 Activity

Activity

90% Killing
Toxicity
60 µM
Cytotoxic
90% Killing | 60 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
A peptide of heparin cofactor II inhibits endotoxin-mediated shock and invasive Pseudomonas aeruginosa infection. | PLoS One | 2014
Evidence 3 Activity

Activity

25% Killing
Toxicity
60 µM
Cytotoxic
25% Killing | 60 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
A peptide of heparin cofactor II inhibits endotoxin-mediated shock and invasive Pseudomonas aeruginosa infection. | PLoS One | 2014