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Peptide record

TPDB11065

Antibacterial Anticancer Antifungal Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11065
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
ALWKDLLKNVGKAAGKAVLNKVTDMVNQ
Physicochemical Analysis
C135H230N38O38S1
RCEHIFPSY
K
3025.60
10.38
5
2
14
+3
4.69
-0.064
111.43
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
181.78
5
Residue Composition
number
4
A
0
R
3
N
2
D
0
C
0
E
1
Q
2
G
0
H
0
I
4
L
5
K
1
M
0
F
0
P
0
S
1
T
1
W
0
Y
4
V
Amino Acid Distribution
A: 4 R: 0 N: 3 D: 2 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 4 K: 5 M: 1 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 4
Chemical Descriptors
28
C135H230N38O38S1
3025.60
10.38
+3
4.69
-0.064
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus MRSA (MIC 4-8 uM), E. coli (MIC 4 uM) and C. albicans (MIC 4 uM), P. aeruginosa (MIC 8 uM), K. pneumoniae (
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Active against S. aureus MRSA (MIC 4-8 uM), E. coli (MIC 4 uM) and C. albicans (MIC 4 uM), P. aeruginosa (MIC 8 uM), K. pneumoniae (MIC 8 uM), and E.fae
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

Active against S. aureus MRSA (MIC 4-8 uM), E. coli (MIC 4 uM) and C. albicans (MIC 4 uM), P. aeruginosa (MIC 8 uM), K. pneumoniae (MIC 8 uM), and E.faecalis (MIC 128 uM). MBC can
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

ctive against S. aureus MRSA (MIC 4-8 uM), E. coli (MIC 4 uM) and C. albicans (MIC 4 uM), P. aeruginosa (MIC 8 uM), K. pneumoniae (MIC 8 uM), and E.faecalis (MIC 128 uM). MBC can much higher. Horse blood
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP

Other

SA (MIC 4-8 uM), E. coli (MIC 4 uM) and C. albicans (MIC 4 uM), P. aeruginosa (MIC 8 uM), K. pneumoniae (MIC 8 uM), and E.faecalis (MIC 128 uM). MBC can much higher. Horse blood RBC: HC50 114.7 uM, not he
Evidence 6 Activity

Activity

MIC
Antibacterial
128 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP

Other

4 uM) and C. albicans (MIC 4 uM), P. aeruginosa (MIC 8 uM), K. pneumoniae (MIC 8 uM), and E.faecalis (MIC 128 uM). MBC can much higher. Horse blood RBC: HC50 114.7 uM, not hemo.lytic.
Evidence 7 Activity

Activity

MIC
Antifungal
4-8 µM

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus MRSA (MIC 4-8 uM), E. coli (MIC 4 uM) and C. albicans (MIC 4 uM), P. aeruginosa (MIC 8 uM), K. pneumoniae (
Evidence 8 Activity

Activity

MIC
Antifungal
4 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus MRSA (MIC 4-8 uM), E. coli (MIC 4 uM) and C. albicans (MIC 4 uM), P. aeruginosa (MIC 8 uM), K. pneumoniae (MIC 8 uM), and E.fae
Evidence 9 Activity

Activity

MIC
Antifungal
4 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus MRSA (MIC 4-8 uM), E. coli (MIC 4 uM) and C. albicans (MIC 4 uM), P. aeruginosa (MIC 8 uM), K. pneumoniae (MIC 8 uM), and E.faecalis (MIC 128 uM). MBC can
Evidence 10 Activity

Activity

MIC
Antifungal
8 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ctive against S. aureus MRSA (MIC 4-8 uM), E. coli (MIC 4 uM) and C. albicans (MIC 4 uM), P. aeruginosa (MIC 8 uM), K. pneumoniae (MIC 8 uM), and E.faecalis (MIC 128 uM). MBC can much higher. Horse blood
Evidence 11 Activity

Activity

MIC
Antifungal
8 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

SA (MIC 4-8 uM), E. coli (MIC 4 uM) and C. albicans (MIC 4 uM), P. aeruginosa (MIC 8 uM), K. pneumoniae (MIC 8 uM), and E.faecalis (MIC 128 uM). MBC can much higher. Horse blood RBC: HC50 114.7 uM, not he
Evidence 12 Activity

Activity

MIC
Antifungal
128 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

4 uM) and C. albicans (MIC 4 uM), P. aeruginosa (MIC 8 uM), K. pneumoniae (MIC 8 uM), and E.faecalis (MIC 128 uM). MBC can much higher. Horse blood RBC: HC50 114.7 uM, not hemo.lytic.
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
114.7 µM
Hemolytic Cytotoxic
50% Hemolysis | 114.7 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells. | PeerJ | 2018
Evidence 14 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells. | PeerJ | 2018