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Peptide record

TPDB11058

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11058
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP AI4AVP DRAVP 2.0 CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ALWMTLLKKVLKAAAKAALNAVLVGANA
Physicochemical Analysis
C132H229N35O32S1
RDCEQHIFPSY
A
2850.55
11.00
4
0
20
+4
-1.81
1.032
146.79
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
192.95
3
Residue Composition
number
9
A
0
R
2
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
6
L
4
K
1
M
0
F
0
P
0
S
1
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 9 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 6 K: 4 M: 1 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 3
Chemical Descriptors
28
C132H229N35O32S1
2850.55
11.00
+4
-1.81
1.032
Evidence Records 67 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

A. caviae IP67-16T

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. b
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli IP76-24

Source & Reference

dbAMP DRAMP

Other

Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10
Evidence 3 Activity

Activity

MIC
Antibacterial
10-20 µM

Target

Staphylococcus aureus IP76-25

Source & Reference

dbAMP DRAMP

Other

gainst A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP
Evidence 4 Activity

Activity

MIC
Antibacterial
10 µM

Target

N. brasiliensis IP118079

Source & Reference

dbAMP DRAMP

Other

uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP884-65, IP886-65 (MIC 20 uM), C. neofo
Evidence 5 Activity

Activity

MIC
Antibacterial
20 µM

Target

S. cerevisiae IP118079

Source & Reference

dbAMP DRAMP

Other

aecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP884-65, IP886-65 (MIC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2
Evidence 6 Activity

Activity

MIC
Antibacterial
1-2 µM

Target

C. neoformans IP960-67 and IP962-67

Source & Reference

dbAMP DRAMP

Other

C 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP884-65, IP886-65 (MIC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71
Evidence 7 Activity

Activity

MIC
Antibacterial
15 µM

Target

M. canis IP1194

Source & Reference

dbAMP DRAMP

Other

lbicans IP884-65, IP886-65 (MIC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-
Evidence 8 Activity

Activity

MIC
Antibacterial
40 µM

Target

T. rubrum IP2043-92

Source & Reference

dbAMP DRAMP

Other

IC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii
Evidence 9 Activity

Activity

MIC
Antibacterial
20 µM

Target

T. metagrophytes IP877-71

Source & Reference

dbAMP DRAMP

Other

and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 20 uM), A. niger IP218-53 and
Evidence 10 Activity

Activity

MIC
Antibacterial
20 µM

Target

A. simii J43

Source & Reference

dbAMP DRAMP

Other

IC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 20 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (M
Evidence 11 Activity

Activity

MIC
Antibacterial
20-30 µM

Target

A. fumigatus IP1025-70

Source & Reference

dbAMP DRAMP

Other

, A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 20 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrh
Evidence 12 Activity

Activity

MIC
Antibacterial
13-29 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

(MIC 20 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrheae (MIC 51-103ug/ml). It also showed activ
Evidence 13 Activity

Activity

MIC
Antibacterial
11.5-26 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrheae (MIC 51-103ug/ml). It also showed activities against P. falciparum (ant
Evidence 14 Activity

Activity

MIC
Antibacterial
51-103 µg/mL

Target

N. gonorrheae

Source & Reference

dbAMP DRAMP

Other

20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrheae (MIC 51-103ug/ml). It also showed activities against P. falciparum (antimalarial) as well as human sperm. I
Evidence 15 Activity

Activity

MIC
Antifungal
0.5 µM

Target

A. caviae IP67-16T

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. b
Evidence 16 Activity

Activity

MIC
Antifungal
4 µM

Target

Escherichia coli IP76-24

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10
Evidence 17 Activity

Activity

MIC
Antifungal
10-20 µM

Target

Staphylococcus aureus IP76-25

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

gainst A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP
Evidence 18 Activity

Activity

MIC
Antifungal
10 µM

Target

N. brasiliensis IP118079

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP884-65, IP886-65 (MIC 20 uM), C. neofo
Evidence 19 Activity

Activity

MIC
Antifungal
20 µM

Target

S. cerevisiae IP118079

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

aecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP884-65, IP886-65 (MIC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2
Evidence 20 Activity

Activity

MIC
Antifungal
1-2 µM

Target

C. neoformans IP960-67 and IP962-67

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP884-65, IP886-65 (MIC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71
Evidence 21 Activity

Activity

MIC
Antifungal
15 µM

Target

M. canis IP1194

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

lbicans IP884-65, IP886-65 (MIC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-
Evidence 22 Activity

Activity

MIC
Antifungal
40 µM

Target

T. rubrum IP2043-92

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii
Evidence 23 Activity

Activity

MIC
Antifungal
20 µM

Target

T. metagrophytes IP877-71

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 20 uM), A. niger IP218-53 and
Evidence 24 Activity

Activity

MIC
Antifungal
20 µM

Target

A. simii J43

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 20 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (M
Evidence 25 Activity

Activity

MIC
Antifungal
20-30 µM

Target

A. fumigatus IP1025-70

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 20 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrh
Evidence 26 Activity

Activity

MIC
Antifungal
13-29 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 20 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrheae (MIC 51-103ug/ml). It also showed activ
Evidence 27 Activity

Activity

MIC
Antifungal
11.5-26 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrheae (MIC 51-103ug/ml). It also showed activities against P. falciparum (ant
Evidence 28 Activity

Activity

MIC
Antifungal
51-103 µg/mL

Target

N. gonorrheae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrheae (MIC 51-103ug/ml). It also showed activities against P. falciparum (antimalarial) as well as human sperm. I
Evidence 29 Activity

Activity

MIC
Antiparasitic
0.5 µM

Target

A. caviae IP67-16T

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. b
Evidence 30 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Escherichia coli IP76-24

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10
Evidence 31 Activity

Activity

MIC
Antiparasitic
10-20 µM

Target

Staphylococcus aureus IP76-25

Source & Reference

dbAMP 3.0 DRAMP

Other

gainst A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP
Evidence 32 Activity

Activity

MIC
Antiparasitic
10 µM

Target

N. brasiliensis IP118079

Source & Reference

dbAMP 3.0 DRAMP

Other

uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP884-65, IP886-65 (MIC 20 uM), C. neofo
Evidence 33 Activity

Activity

MIC
Antiparasitic
20 µM

Target

S. cerevisiae IP118079

Source & Reference

dbAMP 3.0 DRAMP

Other

aecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP884-65, IP886-65 (MIC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2
Evidence 34 Activity

Activity

MIC
Antiparasitic
1-2 µM

Target

C. neoformans IP960-67 and IP962-67

Source & Reference

dbAMP 3.0 DRAMP

Other

C 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP884-65, IP886-65 (MIC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71
Evidence 35 Activity

Activity

MIC
Antiparasitic
15 µM

Target

M. canis IP1194

Source & Reference

dbAMP 3.0 DRAMP

Other

lbicans IP884-65, IP886-65 (MIC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-
Evidence 36 Activity

Activity

MIC
Antiparasitic
40 µM

Target

T. rubrum IP2043-92

Source & Reference

dbAMP 3.0 DRAMP

Other

IC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii
Evidence 37 Activity

Activity

MIC
Antiparasitic
20 µM

Target

T. metagrophytes IP877-71

Source & Reference

dbAMP 3.0 DRAMP

Other

and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 20 uM), A. niger IP218-53 and
Evidence 38 Activity

Activity

MIC
Antiparasitic
20 µM

Target

A. simii J43

Source & Reference

dbAMP 3.0 DRAMP

Other

IC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 20 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (M
Evidence 39 Activity

Activity

MIC
Antiparasitic
20-30 µM

Target

A. fumigatus IP1025-70

Source & Reference

dbAMP 3.0 DRAMP

Other

, A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 20 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrh
Evidence 40 Activity

Activity

MIC
Antiparasitic
13-29 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

(MIC 20 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrheae (MIC 51-103ug/ml). It also showed activ
Evidence 41 Activity

Activity

MIC
Antiparasitic
11.5-26 µg/mL

Target

Candida albicans

Source & Reference

dbAMP 3.0 DRAMP

Other

-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrheae (MIC 51-103ug/ml). It also showed activities against P. falciparum (ant
Evidence 42 Activity

Activity

MIC
Antiparasitic
51-103 µg/mL

Target

N. gonorrheae

Source & Reference

dbAMP 3.0 DRAMP

Other

20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrheae (MIC 51-103ug/ml). It also showed activities against P. falciparum (antimalarial) as well as human sperm. I
Evidence 43 Activity

Activity

MIC
Antiviral
0.5 µM

Target

A. caviae IP67-16T

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. b
Evidence 44 Activity

Activity

MIC
Antiviral
4 µM

Target

Escherichia coli IP76-24

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10
Evidence 45 Activity

Activity

MIC
Antiviral
10-20 µM

Target

Staphylococcus aureus IP76-25

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

gainst A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP
Evidence 46 Activity

Activity

MIC
Antiviral
10 µM

Target

N. brasiliensis IP118079

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP884-65, IP886-65 (MIC 20 uM), C. neofo
Evidence 47 Activity

Activity

MIC
Antiviral
20 µM

Target

S. cerevisiae IP118079

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

aecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP884-65, IP886-65 (MIC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2
Evidence 48 Activity

Activity

MIC
Antiviral
1-2 µM

Target

C. neoformans IP960-67 and IP962-67

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

C 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP884-65, IP886-65 (MIC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71
Evidence 49 Activity

Activity

MIC
Antiviral
15 µM

Target

M. canis IP1194

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

lbicans IP884-65, IP886-65 (MIC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-
Evidence 50 Activity

Activity

MIC
Antiviral
40 µM

Target

T. rubrum IP2043-92

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

IC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii
Evidence 51 Activity

Activity

MIC
Antiviral
20 µM

Target

T. metagrophytes IP877-71

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 20 uM), A. niger IP218-53 and
Evidence 52 Activity

Activity

MIC
Antiviral
20 µM

Target

A. simii J43

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

IC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 20 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (M
Evidence 53 Activity

Activity

MIC
Antiviral
20-30 µM

Target

A. fumigatus IP1025-70

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

, A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 20 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrh
Evidence 54 Activity

Activity

MIC
Antiviral
13-29 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

(MIC 20 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrheae (MIC 51-103ug/ml). It also showed activ
Evidence 55 Activity

Activity

MIC
Antiviral
11.5-26 µg/mL

Target

Candida albicans

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrheae (MIC 51-103ug/ml). It also showed activities against P. falciparum (ant
Evidence 56 Activity

Activity

MIC
Antiviral
51-103 µg/mL

Target

N. gonorrheae

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrheae (MIC 51-103ug/ml). It also showed activities against P. falciparum (antimalarial) as well as human sperm. I
Evidence 57 Activity

Activity

Hemolysis
[Swiss_Prot Entry P80280]Strong hemolytic activity

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Eur. J. Biochem. 1994 219:145-154.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 58 Activity

Activity

68.5±10.83% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
68.5±10.83% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620. | Environ Sci Pollut Res Int | 2021
Evidence 59 Activity

Activity

50% Hemolysis
Toxicity
1.4±0.2 µM
Hemolytic Cytotoxic
50% Hemolysis | 1.4±0.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity | J Biol Chem | 2000
Evidence 60 Activity

Activity

50% Hemolysis
Toxicity
0.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 0.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Selective cytotoxicity of dermaseptin S3 toward intraerythrocytic Plasmodium falciparum and the underlying molecular basis. | J Biol Chem | 1997
Evidence 61 Activity

Activity

50% Hemolysis
Toxicity
>8.5 µM
Hemolytic Cytotoxic
50% Hemolysis | >8.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Selective cytotoxicity of dermaseptin S3 toward intraerythrocytic Plasmodium falciparum and the underlying molecular basis. | J Biol Chem | 1997
Evidence 62 Activity

Activity

50% Hemolysis
Toxicity
1.5±0.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 1.5±0.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural requirements for potent versus selective cytotoxicity for antimicrobial dermaseptin S4 derivatives. | J Biol Chem | 2002
Evidence 63 Activity

Activity

12% Cytotoxicity
Toxicity
10 µM
Cytotoxic
12% Cytotoxicity | 10 | µM | target cell: Baby Hamster Kidney cells BHK-21 BSR

Target

Baby Hamster Kidney cells BHK-21 BSR

Source & Reference

NA
DBAASP
Dermaseptins as Potential Antirabies Compounds | Vaccine | 2019
Evidence 64 Activity

Activity

50% Cytotoxicity
Toxicity
7.50 µM
Cytotoxic
50% Cytotoxicity | 7.50 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In Vitro Antiviral Activity of Dermaseptin S(4) and Derivatives From Amphibian Skin Against Herpes Simplex Virus Type 2 | J Med Virol | 2013
Evidence 65 Activity

Activity

80±3.32% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
80±3.32% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620. | Environ Sci Pollut Res Int | 2021
Evidence 66 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Swiss_Prot Entry P80280]Strong hemolytic activity

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur. J. Biochem. 1994 219:145-154.
Evidence 67 Hemolysis

Activity

[Swiss_Prot Entry P80280]Strong hemolytic activity
Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Eur. J. Biochem. 1994 219:145-154.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.