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Peptide record

TPDB11053

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11053
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GYGGHGGHGGHGGHGGHGGHGHGGGGHG
Physicochemical Analysis
C95H124N44O30
ARNDCEQILKMFPSTWV
G
2362.31
8.23
8
0
1
+1
6.93
-1.232
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
63.07
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
19
G
8
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 19 H: 8 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
28
C95H124N44O30
2362.31
8.23
+1
6.93
-1.232
Evidence Records 36 records
Evidence 1 Activity

Activity

IC50
Antibacterial
62 µg/mL

Target

E. herbicola

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
IC50: 50% reduction in CFU. active against Gram- E. herbicola (IC50 62 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi
Evidence 2 Activity

Activity

IC50
Antibacterial
100 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

IC50: 50% reduction in CFU. active against Gram- E. herbicola (IC50 62 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml)
Evidence 3 Activity

Activity

IC50
Antibacterial
>100 µg/mL

Target

S.aureus

Source & Reference

dbAMP DRAMP

Other

tion in CFU. active against Gram- E. herbicola (IC50 62 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug
Evidence 4 Activity

Activity

IC50
Antibacterial
>100 µg/mL

Target

S.mutans

Source & Reference

dbAMP DRAMP

Other

Gram- E. herbicola (IC50 62 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug/ml), and F. culmorum (IC50
Evidence 5 Activity

Activity

IC50
Antibacterial
8 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

, E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug/ml), and F. culmorum (IC50 72 ug/ml). Also, a 2014 paper repo
Evidence 6 Activity

Activity

IC50
Antibacterial
100 µg/mL

Target

C. neoformans

Source & Reference

dbAMP DRAMP

Other

S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug/ml), and F. culmorum (IC50 72 ug/ml). Also, a 2014 paper reported MIC against C. albicans MDM
Evidence 7 Activity

Activity

IC50
Antibacterial
72 µg/mL

Target

F. culmorum

Source & Reference

dbAMP DRAMP

Other

(IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug/ml), and F. culmorum (IC50 72 ug/ml). Also, a 2014 paper reported MIC against C. albicans MDM8 or ATCC 90028 or fluconazole-re
Evidence 8 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

Candida albicans MDM8 or ATCC 90028 or fluconazole-resistant HU 168

Source & Reference

dbAMP DRAMP

Other

IC50 100 ug/ml), and F. culmorum (IC50 72 ug/ml). Also, a 2014 paper reported MIC against C. albicans MDM8 or ATCC 90028 or fluconazole-resistant HU 168 (MIC 12.5-25 uM), C. parapsilosis ATCC 22019 (MIC 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis
Evidence 9 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP DRAMP

Other

against C. albicans MDM8 or ATCC 90028 or fluconazole-resistant HU 168 (MIC 12.5-25 uM), C. parapsilosis ATCC 22019 (MIC 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis Squibb 1600 (MIC 1.56 uM), and S. cerevis
Evidence 10 Activity

Activity

MIC
Antibacterial
50 µM

Target

C. krusei ATCC 6258

Source & Reference

dbAMP DRAMP

Other

fluconazole-resistant HU 168 (MIC 12.5-25 uM), C. parapsilosis ATCC 22019 (MIC 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis Squibb 1600 (MIC 1.56 uM), and S. cerevisiae ATCC 2601 (MIC 12.5 uM) ( Rem
Evidence 11 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

C. tropicalis Squibb 1600

Source & Reference

dbAMP DRAMP

Other

C 12.5-25 uM), C. parapsilosis ATCC 22019 (MIC 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis Squibb 1600 (MIC 1.56 uM), and S. cerevisiae ATCC 2601 (MIC 12.5 uM) ( Remuzgo et al., 2014 ).
Evidence 12 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

S. cerevisiae ATCC 2601

Source & Reference

dbAMP DRAMP

Other

C 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis Squibb 1600 (MIC 1.56 uM), and S. cerevisiae ATCC 2601 (MIC 12.5 uM) ( Remuzgo et al., 2014 ).
Evidence 13 Activity

Activity

IC50
Antifungal
62 µg/mL

Target

E. herbicola

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
IC50: 50% reduction in CFU. active against Gram- E. herbicola (IC50 62 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi
Evidence 14 Activity

Activity

IC50
Antifungal
100 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC50: 50% reduction in CFU. active against Gram- E. herbicola (IC50 62 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml)
Evidence 15 Activity

Activity

IC50
Antifungal
>100 µg/mL

Target

S.aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

tion in CFU. active against Gram- E. herbicola (IC50 62 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug
Evidence 16 Activity

Activity

IC50
Antifungal
>100 µg/mL

Target

S.mutans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Gram- E. herbicola (IC50 62 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug/ml), and F. culmorum (IC50
Evidence 17 Activity

Activity

IC50
Antifungal
8 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug/ml), and F. culmorum (IC50 72 ug/ml). Also, a 2014 paper repo
Evidence 18 Activity

Activity

IC50
Antifungal
100 µg/mL

Target

C. neoformans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug/ml), and F. culmorum (IC50 72 ug/ml). Also, a 2014 paper reported MIC against C. albicans MDM
Evidence 19 Activity

Activity

IC50
Antifungal
72 µg/mL

Target

F. culmorum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug/ml), and F. culmorum (IC50 72 ug/ml). Also, a 2014 paper reported MIC against C. albicans MDM8 or ATCC 90028 or fluconazole-re
Evidence 20 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

Candida albicans MDM8 or ATCC 90028 or fluconazole-resistant HU 168

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC50 100 ug/ml), and F. culmorum (IC50 72 ug/ml). Also, a 2014 paper reported MIC against C. albicans MDM8 or ATCC 90028 or fluconazole-resistant HU 168 (MIC 12.5-25 uM), C. parapsilosis ATCC 22019 (MIC 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis
Evidence 21 Activity

Activity

MIC
Antifungal
6.25 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

against C. albicans MDM8 or ATCC 90028 or fluconazole-resistant HU 168 (MIC 12.5-25 uM), C. parapsilosis ATCC 22019 (MIC 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis Squibb 1600 (MIC 1.56 uM), and S. cerevis
Evidence 22 Activity

Activity

MIC
Antifungal
50 µM

Target

C. krusei ATCC 6258

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

fluconazole-resistant HU 168 (MIC 12.5-25 uM), C. parapsilosis ATCC 22019 (MIC 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis Squibb 1600 (MIC 1.56 uM), and S. cerevisiae ATCC 2601 (MIC 12.5 uM) ( Rem
Evidence 23 Activity

Activity

MIC
Antifungal
1.56 µM

Target

C. tropicalis Squibb 1600

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 12.5-25 uM), C. parapsilosis ATCC 22019 (MIC 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis Squibb 1600 (MIC 1.56 uM), and S. cerevisiae ATCC 2601 (MIC 12.5 uM) ( Remuzgo et al., 2014 ).
Evidence 24 Activity

Activity

MIC
Antifungal
12.5 µM

Target

S. cerevisiae ATCC 2601

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis Squibb 1600 (MIC 1.56 uM), and S. cerevisiae ATCC 2601 (MIC 12.5 uM) ( Remuzgo et al., 2014 ).
Evidence 25 Activity

Activity

IC50
Antiparasitic
62 µg/mL

Target

E. herbicola

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
IC50: 50% reduction in CFU. active against Gram- E. herbicola (IC50 62 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi
Evidence 26 Activity

Activity

IC50
Antiparasitic
100 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

IC50: 50% reduction in CFU. active against Gram- E. herbicola (IC50 62 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml)
Evidence 27 Activity

Activity

IC50
Antiparasitic
>100 µg/mL

Target

S.aureus

Source & Reference

DRAMP

Other

tion in CFU. active against Gram- E. herbicola (IC50 62 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug
Evidence 28 Activity

Activity

IC50
Antiparasitic
>100 µg/mL

Target

S.mutans

Source & Reference

DRAMP

Other

Gram- E. herbicola (IC50 62 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug/ml), and F. culmorum (IC50
Evidence 29 Activity

Activity

IC50
Antiparasitic
8 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

, E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug/ml), and F. culmorum (IC50 72 ug/ml). Also, a 2014 paper repo
Evidence 30 Activity

Activity

IC50
Antiparasitic
100 µg/mL

Target

C. neoformans

Source & Reference

DRAMP

Other

S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug/ml), and F. culmorum (IC50 72 ug/ml). Also, a 2014 paper reported MIC against C. albicans MDM
Evidence 31 Activity

Activity

IC50
Antiparasitic
72 µg/mL

Target

F. culmorum

Source & Reference

DRAMP

Other

(IC50 >100 ug/ml), fungi C. albicans (IC50 8 ug/ml), C. neoformans (IC50 100 ug/ml), and F. culmorum (IC50 72 ug/ml). Also, a 2014 paper reported MIC against C. albicans MDM8 or ATCC 90028 or fluconazole-re
Evidence 32 Activity

Activity

MIC
Antiparasitic
12.5-25 µM

Target

Candida albicans MDM8 or ATCC 90028 or fluconazole-resistant HU 168

Source & Reference

DRAMP

Other

IC50 100 ug/ml), and F. culmorum (IC50 72 ug/ml). Also, a 2014 paper reported MIC against C. albicans MDM8 or ATCC 90028 or fluconazole-resistant HU 168 (MIC 12.5-25 uM), C. parapsilosis ATCC 22019 (MIC 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis
Evidence 33 Activity

Activity

MIC
Antiparasitic
6.25 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

DRAMP

Other

against C. albicans MDM8 or ATCC 90028 or fluconazole-resistant HU 168 (MIC 12.5-25 uM), C. parapsilosis ATCC 22019 (MIC 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis Squibb 1600 (MIC 1.56 uM), and S. cerevis
Evidence 34 Activity

Activity

MIC
Antiparasitic
50 µM

Target

C. krusei ATCC 6258

Source & Reference

DRAMP

Other

fluconazole-resistant HU 168 (MIC 12.5-25 uM), C. parapsilosis ATCC 22019 (MIC 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis Squibb 1600 (MIC 1.56 uM), and S. cerevisiae ATCC 2601 (MIC 12.5 uM) ( Rem
Evidence 35 Activity

Activity

MIC
Antiparasitic
1.56 µM

Target

C. tropicalis Squibb 1600

Source & Reference

DRAMP

Other

C 12.5-25 uM), C. parapsilosis ATCC 22019 (MIC 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis Squibb 1600 (MIC 1.56 uM), and S. cerevisiae ATCC 2601 (MIC 12.5 uM) ( Remuzgo et al., 2014 ).
Evidence 36 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

S. cerevisiae ATCC 2601

Source & Reference

DRAMP

Other

C 6.25 uM), C. krusei ATCC 6258 (MIC 50 uM), C. tropicalis Squibb 1600 (MIC 1.56 uM), and S. cerevisiae ATCC 2601 (MIC 12.5 uM) ( Remuzgo et al., 2014 ).