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Peptide record

TPDB11049

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

28 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11049

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLMDVFKGAAKNLLASALDKIRCKVTKC

FASTA

>TPDB11049|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=28
GLMDVFKGAAKNLLASALDKIRCKVTKC

Formula C131H229N37O36S3

Absent Amino Acids EQHPWY

Common Amino Acids K

Mass 2994.67

PI 10.06

Basic Residues 6

Acidic Residues 2

Hydrophobic Residues 13

Net Charge +4

Boman Index 4.00

Hydrophobicity 0.293

Aliphatic Index 104.64

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 4.17

Polar Residues 5

number

Amino Acid Distribution

A: 4 R: 1 N: 1 D: 2 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 4 K: 5 M: 1 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 2

Length

Formula

C131H229N37O36S3

Mass

2994.67

10.06

Net Charge

Boman Index

4.00

Hydrophobicity

0.293

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 13 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli (MIC 13 uM), P-aeruginosa (MIC ND), E-cloacae (MIC ND), K-pneumoniae (MIC ND), S.aureus (MIC >100 uM)

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

st E. coli (MIC 13 uM), P-aeruginosa (MIC ND), E-cloacae (MIC ND), K-pneumoniae (MIC ND), S.aureus (MIC >100 uM), and C. albicans (MIC 100 uM). HC50 150 uM. Updated 11/2019 7/2021

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ruginosa (MIC ND), E-cloacae (MIC ND), K-pneumoniae (MIC ND), S.aureus (MIC >100 uM), and C. albicans (MIC 100 uM). HC50 150 uM. Updated 11/2019 7/2021

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 13 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli (MIC 13 uM), P-aeruginosa (MIC ND), E-cloacae (MIC ND), K-pneumoniae (MIC ND), S.aureus (MIC >100 uM)

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

st E. coli (MIC 13 uM), P-aeruginosa (MIC ND), E-cloacae (MIC ND), K-pneumoniae (MIC ND), S.aureus (MIC >100 uM), and C. albicans (MIC 100 uM). HC50 150 uM. Updated 11/2019 7/2021

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ruginosa (MIC ND), E-cloacae (MIC ND), K-pneumoniae (MIC ND), S.aureus (MIC >100 uM), and C. albicans (MIC 100 uM). HC50 150 uM. Updated 11/2019 7/2021

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 13 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli (MIC 13 uM), P-aeruginosa (MIC ND), E-cloacae (MIC ND), K-pneumoniae (MIC ND), S.aureus (MIC >100 uM)

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism S.aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

st E. coli (MIC 13 uM), P-aeruginosa (MIC ND), E-cloacae (MIC ND), K-pneumoniae (MIC ND), S.aureus (MIC >100 uM), and C. albicans (MIC 100 uM). HC50 150 uM. Updated 11/2019 7/2021

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

ruginosa (MIC ND), E-cloacae (MIC ND), K-pneumoniae (MIC ND), S.aureus (MIC >100 uM), and C. albicans (MIC 100 uM). HC50 150 uM. Updated 11/2019 7/2021

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 13 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against E. coli (MIC 13 uM), P-aeruginosa (MIC ND), E-cloacae (MIC ND), K-pneumoniae (MIC ND), S.aureus (MIC >100 uM)

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >100 µM

Target

Target Organism S.aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

st E. coli (MIC 13 uM), P-aeruginosa (MIC ND), E-cloacae (MIC ND), K-pneumoniae (MIC ND), S.aureus (MIC >100 uM), and C. albicans (MIC 100 uM). HC50 150 uM. Updated 11/2019 7/2021

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 100 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

ruginosa (MIC ND), E-cloacae (MIC ND), K-pneumoniae (MIC ND), S.aureus (MIC >100 uM), and C. albicans (MIC 100 uM). HC50 150 uM. Updated 11/2019 7/2021

Evidence 13 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Hemolysis

Activity Measurement 150 µM

Hemolysis Raw

[Ref.15003829] HC50=150µM against human erythrocytes

Target

RBC Target human erythrocytes

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

Regul Pept. 2004 May 15 118(3):135-141.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 14 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 150 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica. | Regul Pept | 2004

Evidence 15 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Toxicity

Activity Measurement 150 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.15003829] HC50=150µM against human erythrocytes

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Regul Pept. 2004 May 15 118(3):135-141.

Evidence 16 Hemolysis

Activity

Activity Measurement 150 µM

Activity Endpoint HC50

Hemolysis Raw

[Ref.15003829] HC50=150µM against human erythrocytes

Detail Source Activity Hemolysis

Target

RBC Target human erythrocytes

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Reference

Regul Pept. 2004 May 15 118(3):135-141.

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.