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Peptide record

TPDB11048

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11048
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLMDTVKNAAKNLAGQLLDTIKCKMTGC
Physicochemical Analysis
C123H217N35O39S4
REHFPSWY
LK
2938.53
9.05
4
2
11
+2
4.36
0.061
90.71
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
4.25
8
Residue Composition
number
3
A
0
R
2
N
2
D
2
C
0
E
1
Q
3
G
0
H
1
I
4
L
4
K
2
M
0
F
0
P
0
S
3
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 2 D: 2 C: 2 E: 0 Q: 1 G: 3 H: 0 I: 1 L: 4 K: 4 M: 2 F: 0 P: 0 S: 0 T: 3 W: 0 Y: 0 V: 1
Chemical Descriptors
28
C123H217N35O39S4
2938.53
9.05
+2
4.36
0.061
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
30 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 30 uM), but not S.aureus or C.albicans (MIC >200 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
>200 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 30 uM), but not S.aureus or C.albicans (MIC >200 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
30 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 30 uM), but not S.aureus or C.albicans (MIC >200 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
>200 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 30 uM), but not S.aureus or C.albicans (MIC >200 uM).
Evidence 5 Activity

Activity

MIC
Antiparasitic
30 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 30 uM), but not S.aureus or C.albicans (MIC >200 uM).
Evidence 6 Activity

Activity

MIC
Antiparasitic
>200 µM

Target

C.albicans

Source & Reference

DRAMP

Other

Active against E. coli (MIC 30 uM), but not S.aureus or C.albicans (MIC >200 uM).
Evidence 7 Activity

Activity

MIC
Antiviral
30 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli (MIC 30 uM), but not S.aureus or C.albicans (MIC >200 uM).
Evidence 8 Activity

Activity

MIC
Antiviral
>200 µM

Target

C.albicans

Source & Reference

DRAMP

Other

Active against E. coli (MIC 30 uM), but not S.aureus or C.albicans (MIC >200 uM).
Evidence 9 Activity

Activity

HC50
Hemolysis
100 µM
[Ref:12429503] HC50=100 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochim Biophys Acta. 2002 Nov 19 1601(1):55-63.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
50% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata. | Biochim Biophys Acta | 2002
Evidence 11 Activity

Activity

HC50
Toxicity
100 µM
Hemolytic
Hemolytic_activity: [Ref:12429503] HC50=100 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2002 Nov 19 1601(1):55-63.
Evidence 12 Hemolysis

Activity

100 µM
HC50
[Ref:12429503] HC50=100 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biochim Biophys Acta. 2002 Nov 19 1601(1):55-63.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.