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Peptide record

TPDB11047

Ranatuerin-2Ya Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11047
Ranatuerin-2Ya
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLMDTIKGVAKTVAASWLDKLKCKITGC
Physicochemical Analysis
C130H224N34O37S3
RNEQHFPY
K
2951.59
9.65
5
2
12
+3
2.76
0.343
101.07
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5625
190.57
6
Residue Composition
number
3
A
0
R
0
N
2
D
2
C
0
E
0
Q
3
G
0
H
2
I
3
L
5
K
1
M
0
F
0
P
1
S
3
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 2 C: 2 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 3 K: 5 M: 1 F: 0 P: 0 S: 1 T: 3 W: 1 Y: 0 V: 2
Chemical Descriptors
28
C130H224N34O37S3
2951.59
9.65
+3
2.76
0.343
Free
L
Not Available
Free
Antibacterial
North America, leopard frog, Lithobates yavapaiensis
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 50 uM), S. aureus (50 uM), cancer cells HepG2 (LC50 20 uM).
Evidence 2 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2009

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 3 Activity

Activity

MIC
Antifungal
50 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 50 uM), S. aureus (50 uM), cancer cells HepG2 (LC50 20 uM).
Evidence 4 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 50 uM), S. aureus (50 uM), cancer cells HepG2 (LC50 20 uM).
Evidence 5 Activity

Activity

MIC
Antiviral
50 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli (MIC 50 uM), S. aureus (50 uM), cancer cells HepG2 (LC50 20 uM).
Evidence 6 Activity

Activity

LC50
Hemolysis
100 µM
[Ref.19254736] LC50>100 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Toxicon. 2009 Jun 53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis. | Toxicon | 2009
Evidence 8 Activity

Activity

LC50
Toxicity
100 µM
Hemolytic
Hemolytic_activity: [Ref.19254736] LC50>100 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxicon. 2009 Jun 53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.
Evidence 9 Hemolysis

Activity

100 µM
LC50
[Ref.19254736] LC50>100 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
Toxicon. 2009 Jun 53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.