Back to search

Peptide record

TPDB11046

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11046
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFFGKMKEYFKKFGASFKRRFANLKKRL
Physicochemical Analysis
C164H253N45O34S1
DCQHIPTWV
K
3431.15
11.67
10
1
12
+9
2.55
-0.757
35.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
43.43
3
Residue Composition
number
2
A
3
R
1
N
0
D
0
C
1
E
0
Q
3
G
0
H
0
I
2
L
7
K
1
M
6
F
0
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 0 L: 2 K: 7 M: 1 F: 6 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
28
C164H253N45O34S1
3431.15
11.67
+9
2.55
-0.757
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.6 µM

Target

Escherichia coli DH1

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 0.6 uM), P. aeruginosa (MIC 18 uM), Gram+ A. globiformis, B. subtilis (MIC 0.6-1.1 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
18 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 0.6 uM), P. aeruginosa (MIC 18 uM), Gram+ A. globiformis, B. subtilis (MIC 0.6-1.1 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
0.6-1.1 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

coli DH5alpha, E. coli DH1 (MIC 0.6 uM), P. aeruginosa (MIC 18 uM), Gram+ A. globiformis, B. subtilis (MIC 0.6-1.1 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
0.6 µM

Target

Escherichia coli DH1

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 0.6 uM), P. aeruginosa (MIC 18 uM), Gram+ A. globiformis, B. subtilis (MIC 0.6-1.1 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
18 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 0.6 uM), P. aeruginosa (MIC 18 uM), Gram+ A. globiformis, B. subtilis (MIC 0.6-1.1 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
0.6-1.1 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

coli DH5alpha, E. coli DH1 (MIC 0.6 uM), P. aeruginosa (MIC 18 uM), Gram+ A. globiformis, B. subtilis (MIC 0.6-1.1 uM).
Evidence 7 Activity

Activity

MIC
Antiparasitic
0.6 µM

Target

Escherichia coli DH1

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 0.6 uM), P. aeruginosa (MIC 18 uM), Gram+ A. globiformis, B. subtilis (MIC 0.6-1.1 uM).
Evidence 8 Activity

Activity

MIC
Antiparasitic
18 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 0.6 uM), P. aeruginosa (MIC 18 uM), Gram+ A. globiformis, B. subtilis (MIC 0.6-1.1 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
0.6-1.1 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

coli DH5alpha, E. coli DH1 (MIC 0.6 uM), P. aeruginosa (MIC 18 uM), Gram+ A. globiformis, B. subtilis (MIC 0.6-1.1 uM).
Evidence 10 Activity

Activity

% Hemolysis
Hemolysis
20 %
[Ref.16735513]20% hemolytic activity at 40 µM against rabbit erythrocytes

Target

rabbit erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Biol Chem. 2006 Jul 28 281(30):20983-20992.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 11 Activity

Activity

20% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
20% Hemolysis | 40 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity. | J Biol Chem | 2006
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
12 µM
Hemolytic Cytotoxic
50% Hemolysis | 12 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: a case study in latarcins. | FEBS Lett | 2009
Evidence 13 Activity

Activity

27% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
27% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane Interactions of Latarcins: Antimicrobial Peptides from Spider Venom | Int J Mol Sci | 2021
Evidence 14 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.16735513]20% hemolytic activity at 40 µM against rabbit erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2006 Jul 28 281(30):20983-20992.
Evidence 15 Hemolysis

Activity

20 %
% Hemolysis
[Ref.16735513]20% hemolytic activity at 40 µM against rabbit erythrocytes
Hemolysis

Target

rabbit erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Biol Chem. 2006 Jul 28 281(30):20983-20992.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.