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Peptide record

TPDB11041

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11041
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 AI4AVP DRAVP 2.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
ALWKTLLKKVLKAAAKAALKAVLVGANA
Physicochemical Analysis
C135H238N36O31
RDCEQHIMFPSY
A
2861.60
11.21
6
0
19
+6
-0.02
0.811
146.79
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
192.20
2
Residue Composition
number
9
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
6
L
6
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 9 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 6 K: 6 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 3
Chemical Descriptors
28
C135H238N36O31
2861.60
11.21
+6
-0.02
0.811
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.125 µg/mL

Target

A. baumannii

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against A. baumannii (MIC 3.125 ug/ml). MBC: 6.25 ug/ml. virus: it also inhibits Zika virus (ZIKV) (EC50 0.42 ug/ml ) ( Haddad e
Evidence 2 Activity

Activity

MIC
Antifungal
3.125 µg/mL

Target

A. baumannii

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against A. baumannii (MIC 3.125 ug/ml). MBC: 6.25 ug/ml. virus: it also inhibits Zika virus (ZIKV) (EC50 0.42 ug/ml ) ( Haddad e
Evidence 3 Activity

Activity

MIC
Antiparasitic
3.125 µg/mL

Target

A. baumannii

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
active against A. baumannii (MIC 3.125 ug/ml). MBC: 6.25 ug/ml. virus: it also inhibits Zika virus (ZIKV) (EC50 0.42 ug/ml ) ( Haddad e
Evidence 4 Activity

Activity

MIC
Antiviral
3.125 µg/mL

Target

A. baumannii

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
active against A. baumannii (MIC 3.125 ug/ml). MBC: 6.25 ug/ml. virus: it also inhibits Zika virus (ZIKV) (EC50 0.42 ug/ml ) ( Haddad e
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
0.5±0.2 µM
Hemolytic Cytotoxic
50% Hemolysis | 0.5±0.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 6 Activity

Activity

50% Cytotoxicity
Toxicity
25 µM
Cytotoxic
50% Cytotoxicity | 25 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In Vitro Antiviral Activity of Dermaseptin S(4) and Derivatives From Amphibian Skin Against Herpes Simplex Virus Type 2 | J Med Virol | 2013
Evidence 7 Activity

Activity

50% Cytotoxicity
Toxicity
20.89 µg/mL
Cytotoxic
50% Cytotoxicity | 20.89 | µg/mL | target cell: Human microglial cells HMC3

Target

Human microglial cells HMC3

Source & Reference

NA
DBAASP
Evaluation of the antiviral activity of new dermaseptin analogs against Zika virus | Biochem Biophys Rep | 2024
Evidence 8 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.23161023]Vero cells:CC50=25 µM.

Source & Reference

NA
DRAMP
J Med Virol. 2013 Feb 85(2):272-81.
Evidence 9 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis