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Peptide record

TPDB11040

Antibacterial Anticancer Antiparasitic Antiviral Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11040
Antibacterial Anticancer Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AI4AVP, and other sources, with an available 3D structural model.
Sequence
ALWDTLLKKVLKAAAKAALDAVLVGANA
Physicochemical Analysis
C131H224N34O35
RCEQHIMFPSY
A
2835.43
10.16
4
2
19
+2
0.46
0.839
146.79
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
193.97
2
Residue Composition
number
9
A
0
R
1
N
2
D
0
C
0
E
0
Q
1
G
0
H
0
I
6
L
4
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 9 R: 0 N: 1 D: 2 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 6 K: 4 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 3
Chemical Descriptors
28
C131H224N34O35
2835.43
10.16
+2
0.46
0.839
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
5±1 µM
Hemolytic Cytotoxic
50% Hemolysis | 5±1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity | J Biol Chem | 2000
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
17.75 µM
Cytotoxic
50% Cytotoxicity | 17.75 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In Vitro Antiviral Activity of Dermaseptin S(4) and Derivatives From Amphibian Skin Against Herpes Simplex Virus Type 2 | J Med Virol | 2013
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.23161023]Vero cells:CC50=17.75 µM.

Source & Reference

NA
DRAMP
J Med Virol. 2013 Feb 85(2):272-81.
Evidence 4 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis