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Peptide record

TPDB11039

Antibacterial Anticancer Antifungal Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11039
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
KKCKFFCKVKKKIKSIGFQIPIVSIPFK
Physicochemical Analysis
C159H264N38O32S2
ARNDEHLMTWY
K
3284.20
10.82
9
0
11
+9
4.25
0.118
90.36
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
125
3.81
5
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
0
E
1
Q
1
G
0
H
5
I
0
L
9
K
0
M
4
F
2
P
2
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 5 L: 0 K: 9 M: 0 F: 4 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
28
C159H264N38O32S2
3284.20
10.82
+9
4.25
0.118
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.8-5.7 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli (MIC 2.8-5.7 uM), S. dysenteriae, K. peneumoniae (MIC 5.7-22 uM), K.peneumoniae (MIC >200 for one strain),
Evidence 2 Activity

Activity

MIC
Antibacterial
5.7-22 µM

Target

K. peneumoniae

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 2.8-5.7 uM), S. dysenteriae, K. peneumoniae (MIC 5.7-22 uM), K.peneumoniae (MIC >200 for one strain), K. oxytoca (MIC 1.43 uM), P. mirabilis (MIC 5.7
Evidence 3 Activity

Activity

MIC
Antibacterial
1.43 µM

Target

Klebsiella oxytoca

Source & Reference

dbAMP

Other

S. dysenteriae, K. peneumoniae (MIC 5.7-22 uM), K.peneumoniae (MIC >200 for one strain), K. oxytoca (MIC 1.43 uM), P. mirabilis (MIC 5.7 uM), S. maltophilia (MIC 11.4 uM), S. maltophilia, P. aeruginosa A
Evidence 4 Activity

Activity

MIC
Antibacterial
5.7 µM

Target

P. mirabilis

Source & Reference

dbAMP

Other

oniae (MIC 5.7-22 uM), K.peneumoniae (MIC >200 for one strain), K. oxytoca (MIC 1.43 uM), P. mirabilis (MIC 5.7 uM), S. maltophilia (MIC 11.4 uM), S. maltophilia, P. aeruginosa ATCC27853 (MIC 2.9 uM) (most
Evidence 5 Activity

Activity

MIC
Antibacterial
11.4 µM

Target

Stenotrophomonas maltophilia

Source & Reference

dbAMP

Other

neumoniae (MIC >200 for one strain), K. oxytoca (MIC 1.43 uM), P. mirabilis (MIC 5.7 uM), S. maltophilia (MIC 11.4 uM), S. maltophilia, P. aeruginosa ATCC27853 (MIC 2.9 uM) (mostly clinical strains), Gram+ ba
Evidence 6 Activity

Activity

MIC
Antibacterial
2.9 µM

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP

Other

a (MIC 1.43 uM), P. mirabilis (MIC 5.7 uM), S. maltophilia (MIC 11.4 uM), S. maltophilia, P. aeruginosa ATCC27853 (MIC 2.9 uM) (mostly clinical strains), Gram+ bacteria S. aureus (3 active MIC 2.9 uM 3 inactive MIC>
Evidence 7 Activity

Activity

MIC
Antibacterial
2.9 µM

Target

E. faecium

Source & Reference

dbAMP

Other

eria S. aureus (3 active MIC 2.9 uM 3 inactive MIC>200 uM), B. subtilis, S. epidermidis, E. faecium (MIC 2.9 uM), N. asteroides, E. faecalis (MIC 22.8 uM), and fungi C. albicans (clinical strains, MIC 2
Evidence 8 Activity

Activity

MIC
Antibacterial
22.8 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP

Other

nactive MIC>200 uM), B. subtilis, S. epidermidis, E. faecium (MIC 2.9 uM), N. asteroides, E. faecalis (MIC 22.8 uM), and fungi C. albicans (clinical strains, MIC 2.9 to >200 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
2.8-5.7 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli (MIC 2.8-5.7 uM), S. dysenteriae, K. peneumoniae (MIC 5.7-22 uM), K.peneumoniae (MIC >200 for one strain),
Evidence 10 Activity

Activity

MIC
Antifungal
5.7-22 µM

Target

K. peneumoniae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 2.8-5.7 uM), S. dysenteriae, K. peneumoniae (MIC 5.7-22 uM), K.peneumoniae (MIC >200 for one strain), K. oxytoca (MIC 1.43 uM), P. mirabilis (MIC 5.7
Evidence 11 Activity

Activity

MIC
Antifungal
1.43 µM

Target

Klebsiella oxytoca

Source & Reference

dbAMP CAFPdb Antifungipept

Other

S. dysenteriae, K. peneumoniae (MIC 5.7-22 uM), K.peneumoniae (MIC >200 for one strain), K. oxytoca (MIC 1.43 uM), P. mirabilis (MIC 5.7 uM), S. maltophilia (MIC 11.4 uM), S. maltophilia, P. aeruginosa A
Evidence 12 Activity

Activity

MIC
Antifungal
5.7 µM

Target

P. mirabilis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

oniae (MIC 5.7-22 uM), K.peneumoniae (MIC >200 for one strain), K. oxytoca (MIC 1.43 uM), P. mirabilis (MIC 5.7 uM), S. maltophilia (MIC 11.4 uM), S. maltophilia, P. aeruginosa ATCC27853 (MIC 2.9 uM) (most
Evidence 13 Activity

Activity

MIC
Antifungal
11.4 µM

Target

Stenotrophomonas maltophilia

Source & Reference

dbAMP CAFPdb Antifungipept

Other

neumoniae (MIC >200 for one strain), K. oxytoca (MIC 1.43 uM), P. mirabilis (MIC 5.7 uM), S. maltophilia (MIC 11.4 uM), S. maltophilia, P. aeruginosa ATCC27853 (MIC 2.9 uM) (mostly clinical strains), Gram+ ba
Evidence 14 Activity

Activity

MIC
Antifungal
2.9 µM

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

a (MIC 1.43 uM), P. mirabilis (MIC 5.7 uM), S. maltophilia (MIC 11.4 uM), S. maltophilia, P. aeruginosa ATCC27853 (MIC 2.9 uM) (mostly clinical strains), Gram+ bacteria S. aureus (3 active MIC 2.9 uM 3 inactive MIC>
Evidence 15 Activity

Activity

MIC
Antifungal
2.9 µM

Target

E. faecium

Source & Reference

dbAMP CAFPdb Antifungipept

Other

eria S. aureus (3 active MIC 2.9 uM 3 inactive MIC>200 uM), B. subtilis, S. epidermidis, E. faecium (MIC 2.9 uM), N. asteroides, E. faecalis (MIC 22.8 uM), and fungi C. albicans (clinical strains, MIC 2
Evidence 16 Activity

Activity

MIC
Antifungal
22.8 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

nactive MIC>200 uM), B. subtilis, S. epidermidis, E. faecium (MIC 2.9 uM), N. asteroides, E. faecalis (MIC 22.8 uM), and fungi C. albicans (clinical strains, MIC 2.9 to >200 uM).
Evidence 17 Activity

Activity

0% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cathelicidins from the bullfrog Rana catesbeiana provides novel template for peptide antibiotic design. | PLoS One | 2014
Evidence 18 Activity

Activity

3% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cathelicidins from the bullfrog Rana catesbeiana provides novel template for peptide antibiotic design. | PLoS One | 2014
Evidence 19 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Cathelicidins from the bullfrog Rana catesbeiana provides novel template for peptide antibiotic design. | PLoS One | 2014
Evidence 20 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:0% Hemolysis=100µg/ml 3% Hemolysis=200µg/ml | Cytotoxicity: L929: At 200 µg/ml induced 1.1% cell death

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2014 Mar 27 9(3):e93216.