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Peptide record

TPDB11036

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11036
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
RGLRRLGRKIAHGVKKYGPTVLRIIRIA
Physicochemical Analysis
C144H257N51O31
NDCEQMFSW
R
3198.95
12.71
10
0
12
+9
5.36
-0.204
125.36
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
46.58
2
Residue Composition
number
2
A
6
R
0
N
0
D
0
C
0
E
0
Q
4
G
1
H
4
I
3
L
3
K
0
M
0
F
1
P
0
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 4 L: 3 K: 3 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
28
C144H257N51O31
3198.95
12.71
+9
5.36
-0.204
Evidence Records 8 records
Evidence 1 Activity

Activity

4% Hemolysis
Toxicity
4 µM
Hemolytic Cytotoxic
4% Hemolysis | 4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
SMAP-29: a potent antibacterial and antifungal peptide from sheep leukocytes. | FEBS Lett | 1999
Evidence 2 Activity

Activity

19% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
19% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
SMAP-29: a potent antibacterial and antifungal peptide from sheep leukocytes. | FEBS Lett | 1999
Evidence 3 Activity

Activity

67% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
67% Hemolysis | 80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
SMAP-29: a potent antibacterial and antifungal peptide from sheep leukocytes. | FEBS Lett | 1999
Evidence 4 Activity

Activity

3% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
3% Hemolysis | 80 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
SMAP-29: a potent antibacterial and antifungal peptide from sheep leukocytes. | FEBS Lett | 1999
Evidence 5 Activity

Activity

IC50
Toxicity
16 µM
Cytotoxic
IC50 | 16 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Bacterial killing mechanism of sheep myeloid antimicrobial peptide-18 (SMAP-18) and its Trp-substituted analog with improved cell selectivity and reduced mammalian cell toxicity. | Amino Acids | 2014
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
86 µM
Hemolytic Cytotoxic
50% Hemolysis | 86 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Bacterial killing mechanism of sheep myeloid antimicrobial peptide-18 (SMAP-18) and its Trp-substituted analog with improved cell selectivity and reduced mammalian cell toxicity. | Amino Acids | 2014
Evidence 7 Activity

Activity

10% Hemolysis
Toxicity
6.0 µM
Hemolytic Cytotoxic
10% Hemolysis | 6.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The Stereochemical Effect of SMAP-29 and SMAP-18 on Bacterial Selectivity, Membrane Interaction and Anti-Inflammatory Activity | Amino Acids | 2016
Evidence 8 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis