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Peptide record

TPDB11033

ChaC7 Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11033
ChaC7
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IPCGESCVWIPCITAIAGCSCKNKVCYT
Physicochemical Analysis
C127H204N32O37S6
RDQHLMF
C
2963.57
7.62
2
1
10
+1
0.21
0.750
83.57
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
7365
248.52
12
Residue Composition
number
2
A
0
R
1
N
0
D
6
C
1
E
0
Q
2
G
0
H
4
I
0
L
2
K
0
M
0
F
2
P
2
S
2
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 6 E: 1 Q: 0 G: 2 H: 0 I: 4 L: 0 K: 2 M: 0 F: 0 P: 2 S: 2 T: 2 W: 1 Y: 1 V: 2
Chemical Descriptors
28
C127H204N32O37S6
2963.57
7.62
+1
0.21
0.750
Free
L
Not Available
Free
Antibacterial
Chassalia chartacea
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.4 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 6.4 uM), not active against S-aureus and S-epidermis till 80 uM (MIC >80 uM).
Evidence 2 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 3 Activity

Activity

MIC
Antifungal
6.4 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 6.4 uM), not active against S-aureus and S-epidermis till 80 uM (MIC >80 uM).
Evidence 4 Activity

Activity

HD50
Hemolysis
11.6 µM
[Ref.22467870] HD50 = 11.6 µM against on human red blood cells (Type A). Kalata B1 and melittin were used as the positive control.

Target

human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Biol Chem. 2012 May 18 287(21):17598-17607.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
11.6 µM
Hemolytic Cytotoxic
50% Hemolysis | 11.6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities. | J Biol Chem | 2012
Evidence 6 Activity

Activity

HD50
Toxicity
11.6 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.22467870] HD50 = 11.6 µM against on human red blood cells (Type A). Kalata B1 and melittin were used as the positive control. | Cytotoxicity: [Ref.22467870] IC50 = 1.2 µM targeting on HeLa cells. Kalata B1 was used as the positive control.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2012 May 18 287(21):17598-17607.
Evidence 7 Hemolysis

Activity

11.6 µM
HD50
[Ref.22467870] HD50 = 11.6 µM against on human red blood cells (Type A). Kalata B1 and melittin were used as the positive control.
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Biol Chem. 2012 May 18 287(21):17598-17607.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.