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Peptide record

TPDB11029

Antibacterial Anticancer Antifungal Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11029
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
ALWKSLLKNVGKAAGKAALNAVTDMVNQ
Physicochemical Analysis
C129H219N37O37S1
RCEHIFPY
A
2912.44
10.55
4
1
15
+3
2.19
0.150
108.21
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
188.84
6
Residue Composition
number
6
A
0
R
3
N
1
D
0
C
0
E
1
Q
2
G
0
H
0
I
4
L
4
K
1
M
0
F
0
P
1
S
1
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 6 R: 0 N: 3 D: 1 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 4 K: 4 M: 1 F: 0 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 3
Chemical Descriptors
28
C129H219N37O37S1
2912.44
10.55
+3
2.19
0.150
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus MRSA (MIC 4 uM) and E. coli (MIC 4 uM) and C. albicans (MIC 4 uM). DRS-DU-1 was twofold more potent again
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Active against S. aureus MRSA (MIC 4 uM) and E. coli (MIC 4 uM) and C. albicans (MIC 4 uM). DRS-DU-1 was twofold more potent against K. pneumoniae (MIC 4
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

Active against S. aureus MRSA (MIC 4 uM) and E. coli (MIC 4 uM) and C. albicans (MIC 4 uM). DRS-DU-1 was twofold more potent against K. pneumoniae (MIC 4 uM), P. aeruginosa (MIC 4
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP

Other

d E. coli (MIC 4 uM) and C. albicans (MIC 4 uM). DRS-DU-1 was twofold more potent against K. pneumoniae (MIC 4 uM), P. aeruginosa (MIC 4 uM) and E. faecalis (MIC 64 uM) than DRS-CA-1.
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

. albicans (MIC 4 uM). DRS-DU-1 was twofold more potent against K. pneumoniae (MIC 4 uM), P. aeruginosa (MIC 4 uM) and E. faecalis (MIC 64 uM) than DRS-CA-1.
Evidence 6 Activity

Activity

MIC
Antibacterial
64 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP

Other

-1 was twofold more potent against K. pneumoniae (MIC 4 uM), P. aeruginosa (MIC 4 uM) and E. faecalis (MIC 64 uM) than DRS-CA-1.
Evidence 7 Activity

Activity

MIC
Antifungal
4 µM

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus MRSA (MIC 4 uM) and E. coli (MIC 4 uM) and C. albicans (MIC 4 uM). DRS-DU-1 was twofold more potent again
Evidence 8 Activity

Activity

MIC
Antifungal
4 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus MRSA (MIC 4 uM) and E. coli (MIC 4 uM) and C. albicans (MIC 4 uM). DRS-DU-1 was twofold more potent against K. pneumoniae (MIC 4
Evidence 9 Activity

Activity

MIC
Antifungal
4 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus MRSA (MIC 4 uM) and E. coli (MIC 4 uM) and C. albicans (MIC 4 uM). DRS-DU-1 was twofold more potent against K. pneumoniae (MIC 4 uM), P. aeruginosa (MIC 4
Evidence 10 Activity

Activity

MIC
Antifungal
4 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

d E. coli (MIC 4 uM) and C. albicans (MIC 4 uM). DRS-DU-1 was twofold more potent against K. pneumoniae (MIC 4 uM), P. aeruginosa (MIC 4 uM) and E. faecalis (MIC 64 uM) than DRS-CA-1.
Evidence 11 Activity

Activity

MIC
Antifungal
4 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

. albicans (MIC 4 uM). DRS-DU-1 was twofold more potent against K. pneumoniae (MIC 4 uM), P. aeruginosa (MIC 4 uM) and E. faecalis (MIC 64 uM) than DRS-CA-1.
Evidence 12 Activity

Activity

MIC
Antifungal
64 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

-1 was twofold more potent against K. pneumoniae (MIC 4 uM), P. aeruginosa (MIC 4 uM) and E. faecalis (MIC 64 uM) than DRS-CA-1.
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
216.6 µM
Hemolytic Cytotoxic
50% Hemolysis | 216.6 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells. | PeerJ | 2018
Evidence 14 Activity

Activity

IC50
Toxicity
53.75 µM
Cytotoxic
IC50 | 53.75 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells. | PeerJ | 2018
Evidence 15 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
PeerJ. 2018 Sep 19 6:e5635.