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Peptide record

TPDB11028

Antibacterial Anticancer Antifungal Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11028
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia dbACP AFP-GFuse Antifungipept CAFPdb
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
VLLVTLTRLHQRGVIYRKWRHFSGRKYR
Physicochemical Analysis
C163H264N54O35
ANDCEMP
R
3540.23
12.41
10
0
12
+8
2.57
-0.575
100.71
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
8480
239.53
6
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
2
G
2
H
1
I
4
L
2
K
0
M
1
F
0
P
1
S
2
T
1
W
2
Y
3
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 2 I: 1 L: 4 K: 2 M: 0 F: 1 P: 0 S: 1 T: 2 W: 1 Y: 2 V: 3
Chemical Descriptors
28
C163H264N54O35
3540.23
12.41
+8
2.57
-0.575
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3 µM

Target

Staphylococcus aureus ATCC 6538P

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
MIC90 recorded here: Active against Gram+ S. aureus ATCC 6538P (MIC 3 uM), B. subtilis AZ54 (MIC 3 uM), Gram- E. coli DH5alpha (MIC 1.5 uM), P. aeruginosa PAOI or
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µM

Target

B. subtilis AZ54

Source & Reference

dbAMP

Other

MIC90 recorded here: Active against Gram+ S. aureus ATCC 6538P (MIC 3 uM), B. subtilis AZ54 (MIC 3 uM), Gram- E. coli DH5alpha (MIC 1.5 uM), P. aeruginosa PAOI or PA14 or RP73 (MIC 3-6 uM) (th
Evidence 3 Activity

Activity

MIC
Antibacterial
1.5 µM

Target

Escherichia coli DH5alpha

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus ATCC 6538P (MIC 3 uM), B. subtilis AZ54 (MIC 3 uM), Gram- E. coli DH5alpha (MIC 1.5 uM), P. aeruginosa PAOI or PA14 or RP73 (MIC 3-6 uM) (this ref) and 10 clinical strains of C.
Evidence 4 Activity

Activity

MIC
Antibacterial
3-6 µM

Target

Pseudomonas aeruginosa PAOI or PA14 or RP73

Source & Reference

dbAMP

Other

ATCC 6538P (MIC 3 uM), B. subtilis AZ54 (MIC 3 uM), Gram- E. coli DH5alpha (MIC 1.5 uM), P. aeruginosa PAOI or PA14 or RP73 (MIC 3-6 uM) (this ref) and 10 clinical strains of C. albicans ATCC10231 or 80 and 81 (MIC 12.5-25 uM)
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

Candida albicans ATCC10231 or 80 and 81

Source & Reference

dbAMP

Other

M), P. aeruginosa PAOI or PA14 or RP73 (MIC 3-6 uM) (this ref) and 10 clinical strains of C. albicans ATCC10231 or 80 and 81 (MIC 12.5-25 uM), C. parapsilosis 3 or 10 (MIC 25 uM), C. tropicalis 54 or 2 (MIC 12.5 uM), C. glabrata 28
Evidence 6 Activity

Activity

MIC
Antibacterial
25 µM

Target

C. parapsilosis 3 or 10

Source & Reference

dbAMP

Other

this ref) and 10 clinical strains of C. albicans ATCC10231 or 80 and 81 (MIC 12.5-25 uM), C. parapsilosis 3 or 10 (MIC 25 uM), C. tropicalis 54 or 2 (MIC 12.5 uM), C. glabrata 28 or 34 (MIC 50 uM), and C. krusei (MI
Evidence 7 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

C. tropicalis 54 or 2

Source & Reference

dbAMP

Other

C. albicans ATCC10231 or 80 and 81 (MIC 12.5-25 uM), C. parapsilosis 3 or 10 (MIC 25 uM), C. tropicalis 54 or 2 (MIC 12.5 uM), C. glabrata 28 or 34 (MIC 50 uM), and C. krusei (MIC 25 uM) ( Roscetto E et al. 2018 ).
Evidence 8 Activity

Activity

MIC
Antibacterial
50 µM

Target

C. glabrata 28 or 34

Source & Reference

dbAMP

Other

IC 12.5-25 uM), C. parapsilosis 3 or 10 (MIC 25 uM), C. tropicalis 54 or 2 (MIC 12.5 uM), C. glabrata 28 or 34 (MIC 50 uM), and C. krusei (MIC 25 uM) ( Roscetto E et al. 2018 ). Updated 7/2021
Evidence 9 Activity

Activity

MIC
Antibacterial
25 µM

Target

C. krusei

Source & Reference

dbAMP

Other

0 (MIC 25 uM), C. tropicalis 54 or 2 (MIC 12.5 uM), C. glabrata 28 or 34 (MIC 50 uM), and C. krusei (MIC 25 uM) ( Roscetto E et al. 2018 ). Updated 7/2021
Evidence 10 Activity

Activity

MIC
Antifungal
3 µM

Target

Staphylococcus aureus ATCC 6538P

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
MIC90 recorded here: Active against Gram+ S. aureus ATCC 6538P (MIC 3 uM), B. subtilis AZ54 (MIC 3 uM), Gram- E. coli DH5alpha (MIC 1.5 uM), P. aeruginosa PAOI or
Evidence 11 Activity

Activity

MIC
Antifungal
3 µM

Target

B. subtilis AZ54

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MIC90 recorded here: Active against Gram+ S. aureus ATCC 6538P (MIC 3 uM), B. subtilis AZ54 (MIC 3 uM), Gram- E. coli DH5alpha (MIC 1.5 uM), P. aeruginosa PAOI or PA14 or RP73 (MIC 3-6 uM) (th
Evidence 12 Activity

Activity

MIC
Antifungal
1.5 µM

Target

Escherichia coli DH5alpha

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC 6538P (MIC 3 uM), B. subtilis AZ54 (MIC 3 uM), Gram- E. coli DH5alpha (MIC 1.5 uM), P. aeruginosa PAOI or PA14 or RP73 (MIC 3-6 uM) (this ref) and 10 clinical strains of C.
Evidence 13 Activity

Activity

MIC
Antifungal
3-6 µM

Target

Pseudomonas aeruginosa PAOI or PA14 or RP73

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ATCC 6538P (MIC 3 uM), B. subtilis AZ54 (MIC 3 uM), Gram- E. coli DH5alpha (MIC 1.5 uM), P. aeruginosa PAOI or PA14 or RP73 (MIC 3-6 uM) (this ref) and 10 clinical strains of C. albicans ATCC10231 or 80 and 81 (MIC 12.5-25 uM)
Evidence 14 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

Candida albicans ATCC10231 or 80 and 81

Source & Reference

dbAMP CAFPdb Antifungipept

Other

M), P. aeruginosa PAOI or PA14 or RP73 (MIC 3-6 uM) (this ref) and 10 clinical strains of C. albicans ATCC10231 or 80 and 81 (MIC 12.5-25 uM), C. parapsilosis 3 or 10 (MIC 25 uM), C. tropicalis 54 or 2 (MIC 12.5 uM), C. glabrata 28
Evidence 15 Activity

Activity

MIC
Antifungal
25 µM

Target

C. parapsilosis 3 or 10

Source & Reference

dbAMP CAFPdb Antifungipept

Other

this ref) and 10 clinical strains of C. albicans ATCC10231 or 80 and 81 (MIC 12.5-25 uM), C. parapsilosis 3 or 10 (MIC 25 uM), C. tropicalis 54 or 2 (MIC 12.5 uM), C. glabrata 28 or 34 (MIC 50 uM), and C. krusei (MI
Evidence 16 Activity

Activity

MIC
Antifungal
12.5 µM

Target

C. tropicalis 54 or 2

Source & Reference

dbAMP CAFPdb Antifungipept

Other

C. albicans ATCC10231 or 80 and 81 (MIC 12.5-25 uM), C. parapsilosis 3 or 10 (MIC 25 uM), C. tropicalis 54 or 2 (MIC 12.5 uM), C. glabrata 28 or 34 (MIC 50 uM), and C. krusei (MIC 25 uM) ( Roscetto E et al. 2018 ).
Evidence 17 Activity

Activity

MIC
Antifungal
50 µM

Target

C. glabrata 28 or 34

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC 12.5-25 uM), C. parapsilosis 3 or 10 (MIC 25 uM), C. tropicalis 54 or 2 (MIC 12.5 uM), C. glabrata 28 or 34 (MIC 50 uM), and C. krusei (MIC 25 uM) ( Roscetto E et al. 2018 ). Updated 7/2021
Evidence 18 Activity

Activity

MIC
Antifungal
25 µM

Target

C. krusei

Source & Reference

dbAMP CAFPdb Antifungipept

Other

0 (MIC 25 uM), C. tropicalis 54 or 2 (MIC 12.5 uM), C. glabrata 28 or 34 (MIC 50 uM), and C. krusei (MIC 25 uM) ( Roscetto E et al. 2018 ). Updated 7/2021