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Peptide record

TPDB11023

Antibacterial Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11023
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 28-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RGLRRLGRKIAHGVKKYGPTVKRIKRKA
Physicochemical Analysis
C144H260N54O31
NDCEQMFSW
RK
3243.99
12.71
13
0
9
+12
9.51
-1.079
83.57
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
45.93
2
Residue Composition
number
2
A
6
R
0
N
0
D
0
C
0
E
0
Q
4
G
1
H
2
I
2
L
6
K
0
M
0
F
1
P
0
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 2 L: 2 K: 6 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
28
C144H260N54O31
3243.99
12.71
+12
9.51
-1.079
Evidence Records 3 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity analysis of SMAP-29, a sheep leukocytes-derived antimicrobial peptide. | Biochem Biophys Res Commun | 2001
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >>100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity. | Int J Antimicrob Agents | 2011
Evidence 3 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.11467858]Non-hemolysis at 100 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2001 Jul 27 285(4):1046-51.