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Peptide record

TPDB11022

Antibacterial Antifungal Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11022
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RGLRRLGRKIAHGVKKYGATVLRIIRIA
Physicochemical Analysis
C142H255N51O31
NDCEQMFPSW
R
3172.91
12.71
10
0
13
+9
4.74
-0.082
128.93
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
46.96
2
Residue Composition
number
3
A
6
R
0
N
0
D
0
C
0
E
0
Q
4
G
1
H
4
I
3
L
3
K
0
M
0
F
0
P
0
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 3 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 4 L: 3 K: 3 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
28
C142H255N51O31
3172.91
12.71
+9
4.74
-0.082
Evidence Records 4 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
7 13 28 50.4 %
[Ref.11467858]7% hemolysis at 12.5 µM, 13% hemolysis at 25 µg/ml, 28% hemolysis at 50 µg/ml, 50.4% hemolysis at 100 µg/ml against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Biochem Biophys Res Commun. 2001 Jul 27 285(4):1046-51.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
50% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity analysis of SMAP-29, a sheep leukocytes-derived antimicrobial peptide. | Biochem Biophys Res Commun | 2001
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
7 %
Hemolytic
Hemolytic_activity: [Ref.11467858]7% hemolysis at 12.5 µM, 13% hemolysis at 25 µg/ml, 28% hemolysis at 50 µg/ml, 50.4% hemolysis at 100 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2001 Jul 27 285(4):1046-51.
Evidence 4 Hemolysis

Activity

7 13 28 50.4 %
% Hemolysis
[Ref.11467858]7% hemolysis at 12.5 µM, 13% hemolysis at 25 µg/ml, 28% hemolysis at 50 µg/ml, 50.4% hemolysis at 100 µg/ml against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
Biochem Biophys Res Commun. 2001 Jul 27 285(4):1046-51.
DRAMP4
PD_Hemolysis