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Peptide record

TPDB11019

S-24-R2PLx Antibacterial Anticancer Antifungal Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11019
S-24-R2PLx
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb dbAMP
standard
No
A 28-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
GIMDTVKNAAKNLAGQLLDKLKCSITAC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C124H219N35O39S3
REHFPWY
ALK
2920.49
9.05
4
2
12
+2
0.69
0.229
108.21
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
0.04
8
Residue Composition
number
4
A
0
R
2
N
2
D
2
C
0
E
1
Q
2
G
0
H
2
I
4
L
4
K
1
M
0
F
0
P
1
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 2 D: 2 C: 2 E: 0 Q: 1 G: 2 H: 0 I: 2 L: 4 K: 4 M: 1 F: 0 P: 0 S: 1 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
28 reviewed residue count
C124H219N35O39S3 sequence-only estimate (linear, free termini)
2920.49 sequence-only estimate (linear, free termini)
9.05 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
0.69 sequence-only estimate (linear, free termini)
0.229 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
Antimicrobial Activity
Synthetic Analogue of Ranatuerin-2PLx Activity
Evidence Records 19 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 µM

Target

Staphylococcus aureus NCTC 10788

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus NCTC 10788 (MIC 32 uM) and E. coli NCTC 10418 (MIC 32 uM). Inactive: C.albicans NCTC 1467 (MIC 256 uM), MRSA ATC
Evidence 2 Activity

Activity

MIC
Antibacterial
32 µM

Target

Escherichia coli NCTC 10418

Source & Reference

dbAMP

Other

Active against S. aureus NCTC 10788 (MIC 32 uM) and E. coli NCTC 10418 (MIC 32 uM). Inactive: C.albicans NCTC 1467 (MIC 256 uM), MRSA ATCC 12493 (MIC 256 uM) (MRSA-inactive
Evidence 3 Activity

Activity

MIC
Antibacterial
256 µM

Target

C.albicans NCTC 1467

Source & Reference

dbAMP

Other

ve against S. aureus NCTC 10788 (MIC 32 uM) and E. coli NCTC 10418 (MIC 32 uM). Inactive: C.albicans NCTC 1467 (MIC 256 uM), MRSA ATCC 12493 (MIC 256 uM) (MRSA-inactive), E.fecalis NCTC 12697 (MIC 128 uM), and P.a
Evidence 4 Activity

Activity

MIC
Antibacterial
128 µM

Target

E.fecalis NCTC 12697

Source & Reference

dbAMP

Other

nactive: C.albicans NCTC 1467 (MIC 256 uM), MRSA ATCC 12493 (MIC 256 uM) (MRSA-inactive), E.fecalis NCTC 12697 (MIC 128 uM), and P.aeruginosa ATCC 27853 (MIC >512 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
>512 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

uM), MRSA ATCC 12493 (MIC 256 uM) (MRSA-inactive), E.fecalis NCTC 12697 (MIC 128 uM), and P.aeruginosa ATCC 27853 (MIC >512 uM).
Evidence 6 Activity

Activity

IC50
IC50 = 792.60 µM
Anticancer
792.60 µM

Target

Prostate Cancer
PC-3
Prostate

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2018

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 7 Activity

Activity

IC50
IC50 = 58.18 µM
Anticancer
58.18 µM

Target

Lung Cancer
H-157
Lung

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2018
Evidence 8 Activity

Activity

IC50
IC50 = 179.00 µM
Anticancer
179.00 µM

Target

Skin Cancer
MDA-MB-435S
Skin

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2018
Evidence 9 Activity

Activity

IC50
IC50 = 278.30 µM
Anticancer
278.30 µM

Target

Brain Tumor
U-251-MG
Brain

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2018
Evidence 10 Activity

Activity

IC50
IC50 = 316.90 µM
Anticancer
316.90 µM

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2018
Evidence 11 Activity

Activity

MIC
Antifungal
32 µM

Target

Staphylococcus aureus NCTC 10788

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus NCTC 10788 (MIC 32 uM) and E. coli NCTC 10418 (MIC 32 uM). Inactive: C.albicans NCTC 1467 (MIC 256 uM), MRSA ATC
Evidence 12 Activity

Activity

MIC
Antifungal
32 µM

Target

Escherichia coli NCTC 10418

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus NCTC 10788 (MIC 32 uM) and E. coli NCTC 10418 (MIC 32 uM). Inactive: C.albicans NCTC 1467 (MIC 256 uM), MRSA ATCC 12493 (MIC 256 uM) (MRSA-inactive
Evidence 13 Activity

Activity

MIC
Antifungal
256 µM

Target

C.albicans NCTC 1467

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ve against S. aureus NCTC 10788 (MIC 32 uM) and E. coli NCTC 10418 (MIC 32 uM). Inactive: C.albicans NCTC 1467 (MIC 256 uM), MRSA ATCC 12493 (MIC 256 uM) (MRSA-inactive), E.fecalis NCTC 12697 (MIC 128 uM), and P.a
Evidence 14 Activity

Activity

MIC
Antifungal
128 µM

Target

E.fecalis NCTC 12697

Source & Reference

dbAMP CAFPdb Antifungipept

Other

nactive: C.albicans NCTC 1467 (MIC 256 uM), MRSA ATCC 12493 (MIC 256 uM) (MRSA-inactive), E.fecalis NCTC 12697 (MIC 128 uM), and P.aeruginosa ATCC 27853 (MIC >512 uM).
Evidence 15 Activity

Activity

MIC
Antifungal
>512 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

uM), MRSA ATCC 12493 (MIC 256 uM) (MRSA-inactive), E.fecalis NCTC 12697 (MIC 128 uM), and P.aeruginosa ATCC 27853 (MIC >512 uM).
Evidence 16 Activity

Activity

IC50
Toxicity
1185.00 µM
Cytotoxic
IC50 | 1185.00 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells | Biosci Rep | 2018
Evidence 17 Activity

Activity

7% Hemolysis
Toxicity
512 µM
Hemolytic Cytotoxic
7% Hemolysis | 512 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells | Biosci Rep | 2018
Evidence 18 Activity

Activity

<5% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
<5% Hemolysis | 256 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells | Biosci Rep | 2018
Evidence 19 Activity

Activity

IC50
Toxicity
1185.00 µM
Hemolytic Cytotoxic
Hemolytic_activity: Horse erythrocytes: Low haemolytic activity | Cytotoxicity: HMEC-1: IC50=1185.00 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biosci Rep. 2018 Nov 9 38(6):BSR20180710.