Back to search

Peptide record

TPDB11011

Antibacterial Anticancer Antifungal Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11011
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 28-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
DKPKKKPPPPAGPPPPPPPPPGPPPPGP
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C132H202N32O31
RNCEQHILMFSTWYV
P
2733.25
10.55
4
1
1
+3
0.94
-1.746
3.57
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
3
G
0
H
0
I
0
L
4
K
0
M
0
F
19
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 19 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
28 reviewed residue count
C132H202N32O31 sequence-only estimate (linear, free termini)
2733.25 sequence-only estimate (linear, free termini)
10.55 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
0.94 sequence-only estimate (linear, free termini)
-1.746 sequence-only estimate (linear, free termini)
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.053-1.981 µM

Target

A. baumannii

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against A. baumannii (MIC 1.053-1.981 uM), E. coli ATCC 25922 (MIC 3.315-8.511 uM), K. pneumoniae (MIC 2.386-3.304 uM), P. aerugino
Evidence 2 Activity

Activity

MIC
Antibacterial
3.315-8.511 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

active against A. baumannii (MIC 1.053-1.981 uM), E. coli ATCC 25922 (MIC 3.315-8.511 uM), K. pneumoniae (MIC 2.386-3.304 uM), P. aeruginosa ATCC 9027 (MIC 2.662 uM), S. typhimuri
Evidence 3 Activity

Activity

MIC
Antibacterial
2.386-3.304 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP

Other

ctive against A. baumannii (MIC 1.053-1.981 uM), E. coli ATCC 25922 (MIC 3.315-8.511 uM), K. pneumoniae (MIC 2.386-3.304 uM), P. aeruginosa ATCC 9027 (MIC 2.662 uM), S. typhimurium ATCC 14028 (1.447 uM), C. neoform
Evidence 4 Activity

Activity

MIC
Antibacterial
2.662 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP

Other

3-1.981 uM), E. coli ATCC 25922 (MIC 3.315-8.511 uM), K. pneumoniae (MIC 2.386-3.304 uM), P. aeruginosa ATCC 9027 (MIC 2.662 uM), S. typhimurium ATCC 14028 (1.447 uM), C. neoformans 6995 (EC50 2.215 uM), A. fumigatus U
Evidence 5 Activity

Activity

EC50
Antibacterial
2.215 µM

Target

C. neoformans 6995

Source & Reference

dbAMP

Other

-3.304 uM), P. aeruginosa ATCC 9027 (MIC 2.662 uM), S. typhimurium ATCC 14028 (1.447 uM), C. neoformans 6995 (EC50 2.215 uM), A. fumigatus UP1 (EC50 58.68 uM), and C. albicans SC5314 or UP10 (EC50 2.581-34.7 uM), b
Evidence 6 Activity

Activity

EC50
Antibacterial
58.68 µM

Target

A. fumigatus UP1

Source & Reference

dbAMP

Other

(MIC 2.662 uM), S. typhimurium ATCC 14028 (1.447 uM), C. neoformans 6995 (EC50 2.215 uM), A. fumigatus UP1 (EC50 58.68 uM), and C. albicans SC5314 or UP10 (EC50 2.581-34.7 uM), but not S. aureus (EC50 > 100 uM).
Evidence 7 Activity

Activity

EC50
Antibacterial
2.581-34.7 µM

Target

Candida albicans SC5314 or UP10

Source & Reference

dbAMP

Other

028 (1.447 uM), C. neoformans 6995 (EC50 2.215 uM), A. fumigatus UP1 (EC50 58.68 uM), and C. albicans SC5314 or UP10 (EC50 2.581-34.7 uM), but not S. aureus (EC50 > 100 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
1.053-1.981 µM

Target

A. baumannii

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against A. baumannii (MIC 1.053-1.981 uM), E. coli ATCC 25922 (MIC 3.315-8.511 uM), K. pneumoniae (MIC 2.386-3.304 uM), P. aerugino
Evidence 9 Activity

Activity

MIC
Antifungal
3.315-8.511 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against A. baumannii (MIC 1.053-1.981 uM), E. coli ATCC 25922 (MIC 3.315-8.511 uM), K. pneumoniae (MIC 2.386-3.304 uM), P. aeruginosa ATCC 9027 (MIC 2.662 uM), S. typhimuri
Evidence 10 Activity

Activity

MIC
Antifungal
2.386-3.304 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ctive against A. baumannii (MIC 1.053-1.981 uM), E. coli ATCC 25922 (MIC 3.315-8.511 uM), K. pneumoniae (MIC 2.386-3.304 uM), P. aeruginosa ATCC 9027 (MIC 2.662 uM), S. typhimurium ATCC 14028 (1.447 uM), C. neoform
Evidence 11 Activity

Activity

MIC
Antifungal
2.662 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP CAFPdb Antifungipept

Other

3-1.981 uM), E. coli ATCC 25922 (MIC 3.315-8.511 uM), K. pneumoniae (MIC 2.386-3.304 uM), P. aeruginosa ATCC 9027 (MIC 2.662 uM), S. typhimurium ATCC 14028 (1.447 uM), C. neoformans 6995 (EC50 2.215 uM), A. fumigatus U
Evidence 12 Activity

Activity

EC50
Antifungal
2.215 µM

Target

C. neoformans 6995

Source & Reference

dbAMP CAFPdb Antifungipept

Other

-3.304 uM), P. aeruginosa ATCC 9027 (MIC 2.662 uM), S. typhimurium ATCC 14028 (1.447 uM), C. neoformans 6995 (EC50 2.215 uM), A. fumigatus UP1 (EC50 58.68 uM), and C. albicans SC5314 or UP10 (EC50 2.581-34.7 uM), b
Evidence 13 Activity

Activity

EC50
Antifungal
58.68 µM

Target

A. fumigatus UP1

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 2.662 uM), S. typhimurium ATCC 14028 (1.447 uM), C. neoformans 6995 (EC50 2.215 uM), A. fumigatus UP1 (EC50 58.68 uM), and C. albicans SC5314 or UP10 (EC50 2.581-34.7 uM), but not S. aureus (EC50 > 100 uM).
Evidence 14 Activity

Activity

EC50
Antifungal
2.581-34.7 µM

Target

Candida albicans SC5314 or UP10

Source & Reference

dbAMP CAFPdb Antifungipept

Other

028 (1.447 uM), C. neoformans 6995 (EC50 2.215 uM), A. fumigatus UP1 (EC50 58.68 uM), and C. albicans SC5314 or UP10 (EC50 2.581-34.7 uM), but not S. aureus (EC50 > 100 uM).
Evidence 15 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural and functional studies on a proline-rich peptide isolated from swine saliva endowed with antifungal activity towards Cryptococcus neoformans. | Biochim Biophys Acta | 2013
Evidence 16 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Mouse fibroblasts 3T3-Swiss cell line

Target

Mouse fibroblasts 3T3-Swiss cell line

Source & Reference

NA
DBAASP
Structural and functional studies on a proline-rich peptide isolated from swine saliva endowed with antifungal activity towards Cryptococcus neoformans. | Biochim Biophys Acta | 2013
Evidence 17 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Infect Drug Resist. 2018 Jul 17 11:969-979.