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Peptide record

TPDB11010

Antibacterial Anticancer Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB11010
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KIKKGFKKIFKRLPPIGVGVSIPLAGKR
Physicochemical Analysis
C147H255N41O30
NDCEQHMTWY
K
3076.90
12.47
9
0
11
+9
5.42
-0.075
107.86
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
4
I
2
L
7
K
0
M
2
F
3
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 4 L: 2 K: 7 M: 0 F: 2 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
28
C147H255N41O30
3076.90
12.47
+9
5.42
-0.075
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.4-9.0 µM

Target

A. baumannii ATCC 9955 or ATCC BAA-1794

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against A. baumannii ATCC 9955 or ATCC BAA-1794 (MIC 3.4-9.0 uM), E-faecalis ATCC 22192 or 51299 (MIC > 45 uM), E-coli ATCC 4157 (MIC >45 uM), K. pneumoni
Evidence 2 Activity

Activity

MIC
Antibacterial
1.8-9.0 µM

Target

Klebsiella pneumoniae ATCC 33495 or ATCC BAA-1705

Source & Reference

dbAMP DRAMP

Other

3.4-9.0 uM), E-faecalis ATCC 22192 or 51299 (MIC > 45 uM), E-coli ATCC 4157 (MIC >45 uM), K. pneumoniae ATCC 33495 or ATCC BAA-1705 (MIC 1.8-9.0 uM), P. aeruginosa ATCC 9027 (MIC 6.7 uM), and S-aureus ATCC 25923 or 33592 (MIC >13 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
6.7 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP DRAMP

Other

-coli ATCC 4157 (MIC >45 uM), K. pneumoniae ATCC 33495 or ATCC BAA-1705 (MIC 1.8-9.0 uM), P. aeruginosa ATCC 9027 (MIC 6.7 uM), and S-aureus ATCC 25923 or 33592 (MIC >13 uM).
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae. | Dev Comp Immunol | 2017
Evidence 5 Activity

Activity

% Hemolysis
Toxicity
1 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28089718] 1% hemolysis at 300µg/ml against sheep red cells | Cytotoxicity: [Ref.28089718] The survival rate of A549 human lung epithelial cells is 122% at a peptide concentration of 300 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Dev Comp Immunol. 2017 May 70:135-144.