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Peptide record

TPDB10995

Antibacterial Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB10995
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
KIAGKIAKIAGKIAKIAGKIAKIAGKIA
Physicochemical Analysis
C128H238N36O29
RNDCEQHLMFPSTWYV
AIK
2745.52
11.36
8
0
16
+8
4.12
0.629
140.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
8
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
8
I
0
L
8
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 8 L: 0 K: 8 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
28
C128H238N36O29
2745.52
11.36
+8
4.12
0.629
Evidence Records 6 records
Evidence 1 Activity

Activity

41% Hemolysis
Toxicity
8 µg/mL
Hemolytic Cytotoxic
41% Hemolysis | 8 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hydrophobic mismatch demonstrated for membranolytic peptides, and their use as molecular rulers to measure bilayer thickness in native cells. | Sci Rep | 2015
Evidence 2 Activity

Activity

64% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
64% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hydrophobic mismatch demonstrated for membranolytic peptides, and their use as molecular rulers to measure bilayer thickness in native cells. | Sci Rep | 2015
Evidence 3 Activity

Activity

86% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
86% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hydrophobic mismatch demonstrated for membranolytic peptides, and their use as molecular rulers to measure bilayer thickness in native cells. | Sci Rep | 2015
Evidence 4 Activity

Activity

100% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
100% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hydrophobic mismatch demonstrated for membranolytic peptides, and their use as molecular rulers to measure bilayer thickness in native cells. | Sci Rep | 2015
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
1 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 1 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Terminal Charges Modulate the Pore Forming Activity of Cationic Amphipathic Helices. | Biochim Biophys Acta | 2020
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis