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Peptide record

TPDB10993

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB10993
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
GIMDTIKGAAKDLAGQLLDKLKCKITKC
Physicochemical Analysis
C129H231N35O38S3
RNEHFPSWYV
K
2976.64
9.59
6
3
11
+3
6.13
0.036
108.21
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
4.20
5
Residue Composition
number
3
A
0
R
0
N
3
D
2
C
0
E
1
Q
3
G
0
H
3
I
4
L
6
K
1
M
0
F
0
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 3 C: 2 E: 0 Q: 1 G: 3 H: 0 I: 3 L: 4 K: 6 M: 1 F: 0 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
28
C129H231N35O38S3
2976.64
9.59
+3
6.13
0.036
Evidence Records 4 records
Evidence 1 Activity

Activity

HC50
Hemolysis
200 µM
Huµan erythrocytes: HC50>200 µM

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug 150(2):150-4.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae). | Comp Biochem Physiol C Toxicol Pharmacol | 2009
Evidence 3 Activity

Activity

HC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Huµan erythrocytes: HC50>200 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug 150(2):150-4.
Evidence 4 Hemolysis

Activity

200 µM
HC50
Huµan erythrocytes: HC50>200 µM
Hemolysis

Source & Reference

HemoPI PD_Hemolysis
Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug 150(2):150-4.
DRAMP4
PD_Hemolysis