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Peptide record

TPDB10992

Antibacterial Anticancer Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB10992
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GFFGKRKEYFKKFGASFKRRFANLKKRL
Physicochemical Analysis
C165H256N48O34
DCQHIMPTWV
K
3456.15
12.04
11
1
11
+10
3.59
-0.986
35.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
43.11
3
Residue Composition
number
2
A
4
R
1
N
0
D
0
C
1
E
0
Q
3
G
0
H
0
I
2
L
7
K
0
M
6
F
0
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 4 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 0 L: 2 K: 7 M: 0 F: 6 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
28
C165H256N48O34
3456.15
12.04
+10
3.59
-0.986
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>36 µM
Hemolytic Cytotoxic
50% Hemolysis | >36 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: a case study in latarcins. | FEBS Lett | 2009
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis>36 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
FEBS Lett. 2009 Jul 21 583(14):2425-8.