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Peptide record

TPDB10991

Antibacterial Anticancer Antiviral Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB10991
Antibacterial Anticancer Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AI4AVP, and other sources, with an available 3D structural model.
Sequence
ALWKTLLKKVLKAAAKAALNAVLVGANA
Physicochemical Analysis
C133H232N36O32
RDCEQHIMFPSY
A
2847.53
11.12
5
0
19
+5
-0.59
0.825
146.79
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
193.15
3
Residue Composition
number
9
A
0
R
2
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
6
L
5
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 9 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 6 K: 5 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 3
Chemical Descriptors
28
C133H232N36O32
2847.53
11.12
+5
-0.59
0.825
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
2±0.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 2±0.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity | J Biol Chem | 2000
Evidence 2 Activity

Activity

10.5% Cytotoxicity
Toxicity
10 µM
Cytotoxic
10.5% Cytotoxicity | 10 | µM | target cell: Baby Hamster Kidney cells BHK-21 BSR

Target

Baby Hamster Kidney cells BHK-21 BSR

Source & Reference

NA
DBAASP
Dermaseptins as Potential Antirabies Compounds | Vaccine | 2019
Evidence 3 Activity

Activity

50% Cytotoxicity
Toxicity
12 µM
Cytotoxic
50% Cytotoxicity | 12 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In Vitro Antiviral Activity of Dermaseptin S(4) and Derivatives From Amphibian Skin Against Herpes Simplex Virus Type 2 | J Med Virol | 2013
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.23161023]Vero cells:CC50=12 µM.

Source & Reference

NA
DRAMP
J Med Virol. 2013 Feb 85(2):272-81.
Evidence 5 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis