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Peptide record

TPDB10990

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB10990
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.
Sequence
KWKLFKKIGIGAVLKVLTTGLPALKLTK
Physicochemical Analysis
C149H258N36O32
RNDCEQHMSY
K
3065.91
11.29
7
0
14
+7
0.67
0.482
139.29
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
179.39
3
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
2
I
6
L
7
K
0
M
1
F
1
P
0
S
3
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 6 K: 7 M: 0 F: 1 P: 1 S: 0 T: 3 W: 1 Y: 0 V: 2
Chemical Descriptors
28
C149H258N36O32
3065.91
11.29
+7
0.67
0.482
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-8 µg/mL

Target

Pseudomonas aeruginosa PAO1 and mutants or H103 or K799

Source & Reference

NA

Other

active against P. aeruginosa PAO1 and mutants or H103 or K799 (MIC 2-8 ug/ml), E. coli UB1005 or Bort or O111:B4 (MIC 1-8 ug/ml), and S. typhimurium 14028s (MIC 4 ug/m
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

S. typhimurium 14028s

Source & Reference

NA

Other

s or H103 or K799 (MIC 2-8 ug/ml), E. coli UB1005 or Bort or O111:B4 (MIC 1-8 ug/ml), and S. typhimurium 14028s (MIC 4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia A
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Enterobacter cloacae 218S

Source & Reference

NA

Other

coli UB1005 or Bort or O111:B4 (MIC 1-8 ug/ml), and S. typhimurium 14028s (MIC 4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia ATCC 13637 (MIC 12 ug/ml), A. ca
Evidence 4 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

NA

Other

(MIC 1-8 ug/ml), and S. typhimurium 14028s (MIC 4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia ATCC 13637 (MIC 12 ug/ml), A. calcoaceticus 8193 (MIC 1 ug/ml). Binds LPS
Evidence 5 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

X. maltophilia ATCC 13637

Source & Reference

NA

Other

8s (MIC 4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia ATCC 13637 (MIC 12 ug/ml), A. calcoaceticus 8193 (MIC 1 ug/ml). Binds LPS:anti-inflammatory by reducing TNF-alpha r
Evidence 6 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

A. calcoaceticus 8193

Source & Reference

NA

Other

g/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia ATCC 13637 (MIC 12 ug/ml), A. calcoaceticus 8193 (MIC 1 ug/ml). Binds LPS:anti-inflammatory by reducing TNF-alpha released from mouse RAW 264.7 cells.
Evidence 7 Activity

Activity

MIC
Antifungal
2-8 µg/mL

Target

Pseudomonas aeruginosa PAO1 and mutants or H103 or K799

Source & Reference

NA

Other

active against P. aeruginosa PAO1 and mutants or H103 or K799 (MIC 2-8 ug/ml), E. coli UB1005 or Bort or O111:B4 (MIC 1-8 ug/ml), and S. typhimurium 14028s (MIC 4 ug/m
Evidence 8 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

S. typhimurium 14028s

Source & Reference

NA

Other

s or H103 or K799 (MIC 2-8 ug/ml), E. coli UB1005 or Bort or O111:B4 (MIC 1-8 ug/ml), and S. typhimurium 14028s (MIC 4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia A
Evidence 9 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Enterobacter cloacae 218S

Source & Reference

NA

Other

coli UB1005 or Bort or O111:B4 (MIC 1-8 ug/ml), and S. typhimurium 14028s (MIC 4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia ATCC 13637 (MIC 12 ug/ml), A. ca
Evidence 10 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

NA

Other

(MIC 1-8 ug/ml), and S. typhimurium 14028s (MIC 4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia ATCC 13637 (MIC 12 ug/ml), A. calcoaceticus 8193 (MIC 1 ug/ml). Binds LPS
Evidence 11 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

X. maltophilia ATCC 13637

Source & Reference

NA

Other

8s (MIC 4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia ATCC 13637 (MIC 12 ug/ml), A. calcoaceticus 8193 (MIC 1 ug/ml). Binds LPS:anti-inflammatory by reducing TNF-alpha r
Evidence 12 Activity

Activity

MIC
Antifungal
1 µg/mL

Target

A. calcoaceticus 8193

Source & Reference

NA

Other

g/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia ATCC 13637 (MIC 12 ug/ml), A. calcoaceticus 8193 (MIC 1 ug/ml). Binds LPS:anti-inflammatory by reducing TNF-alpha released from mouse RAW 264.7 cells.
Evidence 13 Activity

Activity

MIC
Antiparasitic
2-8 µg/mL

Target

Pseudomonas aeruginosa PAO1 and mutants or H103 or K799

Source & Reference

NA

Other

active against P. aeruginosa PAO1 and mutants or H103 or K799 (MIC 2-8 ug/ml), E. coli UB1005 or Bort or O111:B4 (MIC 1-8 ug/ml), and S. typhimurium 14028s (MIC 4 ug/m
Evidence 14 Activity

Activity

MIC
Antiparasitic
4 µg/mL

Target

S. typhimurium 14028s

Source & Reference

NA

Other

s or H103 or K799 (MIC 2-8 ug/ml), E. coli UB1005 or Bort or O111:B4 (MIC 1-8 ug/ml), and S. typhimurium 14028s (MIC 4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia A
Evidence 15 Activity

Activity

MIC
Antiparasitic
4 µg/mL

Target

Enterobacter cloacae 218S

Source & Reference

NA

Other

coli UB1005 or Bort or O111:B4 (MIC 1-8 ug/ml), and S. typhimurium 14028s (MIC 4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia ATCC 13637 (MIC 12 ug/ml), A. ca
Evidence 16 Activity

Activity

MIC
Antiparasitic
12 µg/mL

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

NA

Other

(MIC 1-8 ug/ml), and S. typhimurium 14028s (MIC 4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia ATCC 13637 (MIC 12 ug/ml), A. calcoaceticus 8193 (MIC 1 ug/ml). Binds LPS
Evidence 17 Activity

Activity

MIC
Antiparasitic
12 µg/mL

Target

X. maltophilia ATCC 13637

Source & Reference

NA

Other

8s (MIC 4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia ATCC 13637 (MIC 12 ug/ml), A. calcoaceticus 8193 (MIC 1 ug/ml). Binds LPS:anti-inflammatory by reducing TNF-alpha r
Evidence 18 Activity

Activity

MIC
Antiparasitic
1 µg/mL

Target

A. calcoaceticus 8193

Source & Reference

NA

Other

g/ml), K. pneumoniae ATCC 13883 (MIC 12 ug/ml), X. maltophilia ATCC 13637 (MIC 12 ug/ml), A. calcoaceticus 8193 (MIC 1 ug/ml). Binds LPS:anti-inflammatory by reducing TNF-alpha released from mouse RAW 264.7 cells.
Evidence 19 Activity

Activity

8% Hemolysis
Toxicity
10 µg/mL
Hemolytic Cytotoxic
8% Hemolysis | 10 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. | Biopolymers | 2005
Evidence 20 Activity

Activity

50% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. | Biopolymers | 2005
Evidence 21 Activity

Activity

75% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
75% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. | Biopolymers | 2005
Evidence 22 Activity

Activity

100% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
100% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. | Biopolymers | 2005
Evidence 23 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis