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Peptide record

TPDB10987

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard

28 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10987

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

GLGSLLGKAFKFGLKTVGKMMGGAPREQ

FASTA

>TPDB10987|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=28
GLGSLLGKAFKFGLKTVGKMMGGAPREQ

Formula C129H216N36O34S2

Absent Amino Acids NDCHIWY

Common Amino Acids G

Mass 2879.47

PI 10.98

Basic Residues 5

Acidic Residues 1

Hydrophobic Residues 11

Net Charge +4

Boman Index 2.93

Hydrophobicity -0.021

Aliphatic Index 73.21

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

Amino Acid Distribution

A: 2 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 7 H: 0 I: 0 L: 4 K: 4 M: 2 F: 2 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 1

Length

Formula

C129H216N36O34S2

Mass

2879.47

10.98

Net Charge

Boman Index

2.93

Hydrophobicity

-0.021

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli (MIC 3 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 25 uM). Hemolytic HL50 =70 uM.

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli (MIC 3 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 25 uM). Hemolytic HL50 =70 uM.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli (MIC 3 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 25 uM). Hemolytic HL50 =70 uM.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli (MIC 3 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 25 uM). Hemolytic HL50 =70 uM.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 3 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 25 uM). Hemolytic HL50 =70 uM.

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 3 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 25 uM). Hemolytic HL50 =70 uM.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 3 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 25 uM). Hemolytic HL50 =70 uM.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 3 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 25 uM). Hemolytic HL50 =70 uM.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 3 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 25 uM). Hemolytic HL50 =70 uM.

Evidence 10 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 70 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 70 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Peptidomic analysis of skin secretions demonstrates that the allopatric populations of Xenopus muelleri (Pipidae) are not conspecific. | Peptides | 2011

Evidence 11 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 214 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 214 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024

Evidence 12 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >256 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024

Evidence 13 Activity

Activity

Activity Endpoint 20% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 256 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

20% Cytotoxicity | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024

Evidence 14 Hemolysis

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.