Peptide record

TPDB10979

Pituitary adenylate cyclase-activating polypeptide 27 Antibacterial Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide standard

27 amino acids

3D PDB MODEL

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TPDB ID TPDB10979

Peptide_Name

Pituitary adenylate cyclase-activating polypeptide 27

Activity

Antibacterial Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide

Activity_category_statistics

Anti-infective peptides Delivery and barrier-penetrating peptides Neuroactive peptides

Database_Source

AntiBP3 Peptipedia B3Pred BBPpredict CPPsite3.0

Sequence_Type

standard

Has_Modification No

Description A 27-aa standard natural multi-activity (Antibacterial, Blood-Brain Barrier, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, B3Pred, and other sources, with an available 3D structural model.

Sequence

HSDGIFTDSYSRYRKQMAVKKYLAAVL

FASTA

>TPDB10979|Antibacterial;Blood-Brain Barrier;Cell-penetrating Peptides;Neuropeptide|length=27
HSDGIFTDSYSRYRKQMAVKKYLAAVL

Formula C142H223N39O40S1

Absent Amino Acids NCEPW

Common Amino Acids AKSY

Mass 3148.63

PI 10.06

Basic Residues 6

Acidic Residues 2

Hydrophobic Residues 13

Net Charge +3

Boman Index 3.15

Hydrophobicity -0.415

Aliphatic Index 75.93

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 4470

Absorbance 280nm 141.97

Polar Residues 8

number

Amino Acid Distribution

A: 3 R: 2 N: 0 D: 2 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 1 L: 2 K: 3 M: 1 F: 1 P: 0 S: 3 T: 1 W: 0 Y: 3 V: 2

Length

Formula

C142H223N39O40S1

Mass

3148.63

10.06

Net Charge

Boman Index

3.15

Hydrophobicity

-0.415

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Pituitary adenylate cyclase-activating polypeptide type I receptor

Receptor Organisms Bos taurus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Glucagon

Receptor Lengths 513

Receptor Ligands NP04401 NP04415 NP04424 NP04450 NP04376 NP04463

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Heloderma suspectum

Family Glucagon

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal polypeptide receptor 2 Pituitary adenylate cyclase-activating polypeptide type I receptor

Receptor Organisms Homo sapiens Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Glucagon

Receptor Lengths 457 438 468

Receptor Ligands NP04418 NP04427 NP04470 NP04418 NP04427 NP04470 NP04418 NP04427

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Pituitary adenylate cyclase-activating polypeptide type I receptor Vasoactive intestinal polypeptide receptor 2

Receptor Organisms Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Glucagon

Receptor Lengths 496 437

Receptor Ligands NP04419 NP04428 NP04419 NP04428 NP04473

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Pelophylax ridibundus

Family Glucagon

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Glucagon

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Pituitary adenylate cyclase-activating polypeptide type I receptor Vasoactive intestinal polypeptide receptor 2

Receptor Organisms Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Glucagon

Receptor Lengths 523 437

Receptor Ligands NP04422 NP04431 NP04422 NP04431 NP04478

Evidence 8 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ovis aries

Family Glucagon

Family

Glucagon

Receptor_Lengths

513 457 438 468 496 437 523

Receptor_Ligands

NP04401 NP04415 NP04424 NP04450 NP04376 NP04463 NP04418 NP04427 NP04470 NP04419 NP04428 NP04473 NP04422 NP04431 NP04478