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Peptide record

TPDB10976

Antibacterial Antifungal Hemolysis Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB10976
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP PD_Hemolysis ToxinPred 3.0
standard
No
A 27-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
SLWGKLKEMAAAAGKAALNAVNGLVNQ
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C120H201N35O35S1
RDCHIFPTY
A
2726.19
10.32
3
1
15
+2
0.16
0.222
105.19
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5500
2.02
5
Residue Composition
number
7
A
0
R
3
N
0
D
0
C
1
E
1
Q
3
G
0
H
0
I
4
L
3
K
1
M
0
F
0
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 7 R: 0 N: 3 D: 0 C: 0 E: 1 Q: 1 G: 3 H: 0 I: 0 L: 4 K: 3 M: 1 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
27 reviewed residue count
C120H201N35O35S1 sequence-only estimate (linear, free termini)
2726.19 sequence-only estimate (linear, free termini)
10.32 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
0.16 sequence-only estimate (linear, free termini)
0.222 sequence-only estimate (linear, free termini)
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus, E. coli (MIC 8 uM), P. aeruginosa, C. albicans (MIC 64 uM), E. faecalis (MIC 32 uM), K. pneumoniae (MIC 32 u
Evidence 2 Activity

Activity

MIC
Antibacterial
64 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

Active against S. aureus, E. coli (MIC 8 uM), P. aeruginosa, C. albicans (MIC 64 uM), E. faecalis (MIC 32 uM), K. pneumoniae (MIC 32 uM), and MRSA (MIC 32 uM). Inhibit biofil
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP

Other

Active against S. aureus, E. coli (MIC 8 uM), P. aeruginosa, C. albicans (MIC 64 uM), E. faecalis (MIC 32 uM), K. pneumoniae (MIC 32 uM), and MRSA (MIC 32 uM). Inhibit biofilm formation of S. aureus,
Evidence 4 Activity

Activity

MIC
Antibacterial
32 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP

Other

eus, E. coli (MIC 8 uM), P. aeruginosa, C. albicans (MIC 64 uM), E. faecalis (MIC 32 uM), K. pneumoniae (MIC 32 uM), and MRSA (MIC 32 uM). Inhibit biofilm formation of S. aureus, not great in biofilm eradi
Evidence 5 Activity

Activity

MIC
Antifungal
8 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus, E. coli (MIC 8 uM), P. aeruginosa, C. albicans (MIC 64 uM), E. faecalis (MIC 32 uM), K. pneumoniae (MIC 32 u
Evidence 6 Activity

Activity

MIC
Antifungal
64 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus, E. coli (MIC 8 uM), P. aeruginosa, C. albicans (MIC 64 uM), E. faecalis (MIC 32 uM), K. pneumoniae (MIC 32 uM), and MRSA (MIC 32 uM). Inhibit biofil
Evidence 7 Activity

Activity

MIC
Antifungal
32 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus, E. coli (MIC 8 uM), P. aeruginosa, C. albicans (MIC 64 uM), E. faecalis (MIC 32 uM), K. pneumoniae (MIC 32 uM), and MRSA (MIC 32 uM). Inhibit biofilm formation of S. aureus,
Evidence 8 Activity

Activity

MIC
Antifungal
32 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

eus, E. coli (MIC 8 uM), P. aeruginosa, C. albicans (MIC 64 uM), E. faecalis (MIC 32 uM), K. pneumoniae (MIC 32 uM), and MRSA (MIC 32 uM). Inhibit biofilm formation of S. aureus, not great in biofilm eradi
Evidence 9 Activity

Activity

10% Hemolysis
Toxicity
26.5 µM
Hemolytic Cytotoxic
10% Hemolysis | 26.5 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Identification and Rational Design of a Novel Antibacterial Peptide Dermaseptin-AC from the Skin Secretion of the Red-Eyed Tree Frog Agalychnis callidryas. | Antibiotics (Basel) | 2020
Evidence 10 Activity

Activity

40% Hemolysis
Toxicity
67 µM
Hemolytic Cytotoxic
40% Hemolysis | 67 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Identification and Rational Design of a Novel Antibacterial Peptide Dermaseptin-AC from the Skin Secretion of the Red-Eyed Tree Frog Agalychnis callidryas. | Antibiotics (Basel) | 2020
Evidence 11 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis