TPDB

3D PDB MODEL

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TPDB ID TPDB10968

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 27-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

FWGAVWKILSKVLPHIPGTVKWLQEKV

FASTA

>TPDB10968|Antibacterial;Antifungal;Toxicity|length=27
FWGAVWKILSKVLPHIPGTVKWLQEKV

Formula C156H239N37O33

Absent Amino Acids RNDCMY

Common Amino Acids KV

Mass 3160.84

PI 10.55

Basic Residues 5

Acidic Residues 1

Hydrophobic Residues 14

Net Charge +3

Boman Index -0.16

Hydrophobicity 0.289

Aliphatic Index 118.89

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 16500

Absorbance 280nm 522.01

Polar Residues 3

number

1

A

0

R

0

N

0

D

0

C

1

E

1

Q

2

G

1

H

2

I

3

L

4

K

0

M

1

F

2

P

1

S

1

T

3

W

0

Y

4

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 2 H: 1 I: 2 L: 3 K: 4 M: 0 F: 1 P: 2 S: 1 T: 1 W: 3 Y: 0 V: 4

Length

27

Formula

C156H239N37O33

Mass

3160.84

PI

10.55

Net Charge

+3

Boman Index

-0.16

Hydrophobicity

0.289

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.2-0.6 µM

Target

Target Organism Escherichia coli MH1

Source & Reference

Database Source NA

Other

Evidence Text

Active against A. globiformis VKM Ac-1112, B. subtilis VKM B-501, E. coli MH1 (MIC 0.2-0.6 uM), E. coli DH5a, and P. aeruginosa PAO1 (MIC 5-10 uM). It is unusual that The peptide was s

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5-10 µM

Target

Target Organism Pseudomonas aeruginosa PAO1

Source & Reference

Database Source NA

Other

Evidence Text

ormis VKM Ac-1112, B. subtilis VKM B-501, E. coli MH1 (MIC 0.2-0.6 uM), E. coli DH5a, and P. aeruginosa PAO1 (MIC 5-10 uM). It is unusual that The peptide was shown to be partially helical in water. updated 12/20

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.2-0.6 µM

Target

Target Organism Escherichia coli MH1

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against A. globiformis VKM Ac-1112, B. subtilis VKM B-501, E. coli MH1 (MIC 0.2-0.6 uM), E. coli DH5a, and P. aeruginosa PAO1 (MIC 5-10 uM). It is unusual that The peptide was s

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5-10 µM

Target

Target Organism Pseudomonas aeruginosa PAO1

Source & Reference

Database Source Antifungipept

Other

Evidence Text

ormis VKM Ac-1112, B. subtilis VKM B-501, E. coli MH1 (MIC 0.2-0.6 uM), E. coli DH5a, and P. aeruginosa PAO1 (MIC 5-10 uM). It is unusual that The peptide was shown to be partially helical in water. updated 12/20