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Peptide record

TPDB10962

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

27 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10962

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

GIGGKILGGLRTALKGAAKELAATYLH

FASTA

>TPDB10962|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=27
GIGGKILGGLRTALKGAAKELAATYLH

Formula C121H207N35O33

Absent Amino Acids NDCQMFPSWV

Common Amino Acids G

Mass 2680.19

PI 10.46

Basic Residues 5

Acidic Residues 1

Hydrophobic Residues 13

Net Charge +3

Boman Index 1.89

Hydrophobicity 0.333

Aliphatic Index 119.63

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 55.59

Polar Residues 3

number

Amino Acid Distribution

A: 5 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 6 H: 1 I: 2 L: 5 K: 3 M: 0 F: 0 P: 0 S: 0 T: 2 W: 0 Y: 1 V: 0

Length

Formula

C121H207N35O33

Mass

2680.19

10.46

Net Charge

Boman Index

1.89

Hydrophobicity

0.333

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.7 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Proteomics: Only active peptides (i.e. AMPs) with MIC 100 ug/ml), S. aureus ATCC 25923 (MIC 4.7 ug/ml), E. coli ATCC 25922 (MIC 9.4 ug/ml), and B. subtilis ATCC 6633 (MIC 75 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.4 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP

Other

Evidence Text

ly active peptides (i.e. AMPs) with MIC 100 ug/ml), S. aureus ATCC 25923 (MIC 4.7 ug/ml), E. coli ATCC 25922 (MIC 9.4 ug/ml), and B. subtilis ATCC 6633 (MIC 75 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 µg/mL

Target

Target Organism B. subtilis ATCC 6633

Source & Reference

Database Source dbAMP

Other

Evidence Text

100 ug/ml), S. aureus ATCC 25923 (MIC 4.7 ug/ml), E. coli ATCC 25922 (MIC 9.4 ug/ml), and B. subtilis ATCC 6633 (MIC 75 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.7 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Proteomics: Only active peptides (i.e. AMPs) with MIC 100 ug/ml), S. aureus ATCC 25923 (MIC 4.7 ug/ml), E. coli ATCC 25922 (MIC 9.4 ug/ml), and B. subtilis ATCC 6633 (MIC 75 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.4 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ly active peptides (i.e. AMPs) with MIC 100 ug/ml), S. aureus ATCC 25923 (MIC 4.7 ug/ml), E. coli ATCC 25922 (MIC 9.4 ug/ml), and B. subtilis ATCC 6633 (MIC 75 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 µg/mL

Target

Target Organism B. subtilis ATCC 6633

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

100 ug/ml), S. aureus ATCC 25923 (MIC 4.7 ug/ml), E. coli ATCC 25922 (MIC 9.4 ug/ml), and B. subtilis ATCC 6633 (MIC 75 ug/ml).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.7 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source NA

Other

Evidence Text

Proteomics: Only active peptides (i.e. AMPs) with MIC 100 ug/ml), S. aureus ATCC 25923 (MIC 4.7 ug/ml), E. coli ATCC 25922 (MIC 9.4 ug/ml), and B. subtilis ATCC 6633 (MIC 75 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 9.4 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

ly active peptides (i.e. AMPs) with MIC 100 ug/ml), S. aureus ATCC 25923 (MIC 4.7 ug/ml), E. coli ATCC 25922 (MIC 9.4 ug/ml), and B. subtilis ATCC 6633 (MIC 75 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 75 µg/mL

Target

Target Organism B. subtilis ATCC 6633

Source & Reference

Database Source NA

Other

Evidence Text

100 ug/ml), S. aureus ATCC 25923 (MIC 4.7 ug/ml), E. coli ATCC 25922 (MIC 9.4 ug/ml), and B. subtilis ATCC 6633 (MIC 75 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4.7 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source NA

Other

Evidence Text

Proteomics: Only active peptides (i.e. AMPs) with MIC 100 ug/ml), S. aureus ATCC 25923 (MIC 4.7 ug/ml), E. coli ATCC 25922 (MIC 9.4 ug/ml), and B. subtilis ATCC 6633 (MIC 75 ug/ml).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 9.4 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

ly active peptides (i.e. AMPs) with MIC 100 ug/ml), S. aureus ATCC 25923 (MIC 4.7 ug/ml), E. coli ATCC 25922 (MIC 9.4 ug/ml), and B. subtilis ATCC 6633 (MIC 75 ug/ml).

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 75 µg/mL

Target

Target Organism B. subtilis ATCC 6633

Source & Reference

Database Source NA

Other

Evidence Text

100 ug/ml), S. aureus ATCC 25923 (MIC 4.7 ug/ml), E. coli ATCC 25922 (MIC 9.4 ug/ml), and B. subtilis ATCC 6633 (MIC 75 ug/ml).

Evidence 13 Activity

Activity

Activity Endpoint 49% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 125 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

49% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

There are abundant antimicrobial peptides in brains of two kinds of Bombina toads. | J Proteome Res | 2011

Evidence 14 Activity

Activity

Activity Endpoint 18% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 62.5 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

18% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

There are abundant antimicrobial peptides in brains of two kinds of Bombina toads. | J Proteome Res | 2011

Evidence 15 Activity

Activity

Activity Endpoint 3% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 125 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

3% Hemolysis | 125 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

There are abundant antimicrobial peptides in brains of two kinds of Bombina toads. | J Proteome Res | 2011

Evidence 16 Activity

Activity

Activity Endpoint 2% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 62.5 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

2% Hemolysis | 62.5 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

There are abundant antimicrobial peptides in brains of two kinds of Bombina toads. | J Proteome Res | 2011

Evidence 17 Hemolysis

Source & Reference

source APD_complete APD_hemolytic PD_Hemolysis

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.