TPDB

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5-1 µM

Target

Target Organism Escherichia coli ATCC 25922 ML-35

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC 25922 ML-35 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcesce

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism S. typhimurium ATCC 14028

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC 25922 ML-35 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATC

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ve against E. coli ATCC 25922 ML-35 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism S. marcescens ATCC 8100

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

C 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

28 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C.

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism B. megaterium Bm11

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism C. neoformans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.5-1 µM

Target

Target Organism Escherichia coli ATCC 25922 ML-35

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC 25922 ML-35 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcesce

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1 µM

Target

Target Organism S. typhimurium ATCC 14028

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC 25922 ML-35 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATC

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.5 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ve against E. coli ATCC 25922 ML-35 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S.

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism S. marcescens ATCC 8100

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

C 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

28 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C.

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM).

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism B. megaterium Bm11

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM).

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM).

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism C. neoformans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.5-1 µM

Target

Target Organism Escherichia coli ATCC 25922 ML-35

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli ATCC 25922 ML-35 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcesce

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1 µM

Target

Target Organism S. typhimurium ATCC 14028

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli ATCC 25922 ML-35 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATC

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.5 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source DRAMP

Other

Evidence Text

ve against E. coli ATCC 25922 ML-35 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S.

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µM

Target

Target Organism S. marcescens ATCC 8100

Source & Reference

Database Source DRAMP

Other

Evidence Text

C 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source DRAMP

Other

Evidence Text

28 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 0.5 uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C.

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source DRAMP

Other

Evidence Text

uM), S. marcescens ATCC 8100 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM).

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism B. megaterium Bm11

Source & Reference

Database Source DRAMP

Other

Evidence Text

), S. aureus ATCC 25923 (MIC 8 uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM).

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

uM) but MRSA >64 uM, S. epidermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM).

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µM

Target

Target Organism C. neoformans

Source & Reference

Database Source DRAMP

Other

Evidence Text

ermidis ATCC 12228 (MIC 2 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM).

Evidence 28 Activity

Activity

Activity Endpoint 3% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

3% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. | J Biol Chem | 1996