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Peptide record

TPDB10957

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

27 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10957

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GIGTKILGGVKTALKGALKELASTYVN

FASTA

>TPDB10957|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=27
GIGTKILGGVKTALKGALKELASTYVN

Formula C122H212N32O36

Absent Amino Acids RDCQHMFPW

Common Amino Acids G

Mass 2703.22

PI 10.31

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 12

Net Charge +3

Boman Index 2.83

Hydrophobicity 0.341

Aliphatic Index 119.26

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 55.12

Polar Residues 6

number

Amino Acid Distribution

A: 3 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 5 H: 0 I: 2 L: 4 K: 4 M: 0 F: 0 P: 0 S: 1 T: 3 W: 0 Y: 1 V: 2

Length

Formula

C122H212N32O36

Mass

2703.22

10.31

Net Charge

Boman Index

2.83

Hydrophobicity

0.341

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 19.5 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 19.5 ug/ml), S. aureus ATCC2592 (MIC 19.5 ug/ml), B. pyocyaneus CMCCB10104 (MIC 19.5 ug/ml), B. megat

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 19.5 µg/mL

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 19.5 ug/ml), S. aureus ATCC2592 (MIC 19.5 ug/ml), B. pyocyaneus CMCCB10104 (MIC 19.5 ug/ml), B. megatherium (MIC 19.5 ug/ml), B. dysenteri

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 19.5 µg/mL

Target

Target Organism B. pyocyaneus CMCCB10104

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 19.5 ug/ml), S. aureus ATCC2592 (MIC 19.5 ug/ml), B. pyocyaneus CMCCB10104 (MIC 19.5 ug/ml), B. megatherium (MIC 19.5 ug/ml), B. dysenterium (MIC 2.7 ug/ml), K. pneumoniae (MIC 9 ug

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 19.5 µg/mL

Target

Target Organism B. megatherium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

5 ug/ml), S. aureus ATCC2592 (MIC 19.5 ug/ml), B. pyocyaneus CMCCB10104 (MIC 19.5 ug/ml), B. megatherium (MIC 19.5 ug/ml), B. dysenterium (MIC 2.7 ug/ml), K. pneumoniae (MIC 9 ug/ml), and C. albicans ATCC2002 (M

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.7 µg/mL

Target

Target Organism B. dysenterium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

19.5 ug/ml), B. pyocyaneus CMCCB10104 (MIC 19.5 ug/ml), B. megatherium (MIC 19.5 ug/ml), B. dysenterium (MIC 2.7 ug/ml), K. pneumoniae (MIC 9 ug/ml), and C. albicans ATCC2002 (MIC 3 uM), A.flavus IFFI4015 (ND)

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9 µg/mL

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

B10104 (MIC 19.5 ug/ml), B. megatherium (MIC 19.5 ug/ml), B. dysenterium (MIC 2.7 ug/ml), K. pneumoniae (MIC 9 ug/ml), and C. albicans ATCC2002 (MIC 3 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND)

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

herium (MIC 19.5 ug/ml), B. dysenterium (MIC 2.7 ug/ml), K. pneumoniae (MIC 9 ug/ml), and C. albicans ATCC2002 (MIC 3 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 19.5 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 19.5 ug/ml), S. aureus ATCC2592 (MIC 19.5 ug/ml), B. pyocyaneus CMCCB10104 (MIC 19.5 ug/ml), B. megat

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 19.5 µg/mL

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 19.5 ug/ml), S. aureus ATCC2592 (MIC 19.5 ug/ml), B. pyocyaneus CMCCB10104 (MIC 19.5 ug/ml), B. megatherium (MIC 19.5 ug/ml), B. dysenteri

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 19.5 µg/mL

Target

Target Organism B. pyocyaneus CMCCB10104

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 19.5 µg/mL

Target

Target Organism B. megatherium

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.7 µg/mL

Target

Target Organism B. dysenterium

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9 µg/mL

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

herium (MIC 19.5 ug/ml), B. dysenterium (MIC 2.7 ug/ml), K. pneumoniae (MIC 9 ug/ml), and C. albicans ATCC2002 (MIC 3 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND).

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 19.5 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli ATCC25922 (MIC 19.5 ug/ml), S. aureus ATCC2592 (MIC 19.5 ug/ml), B. pyocyaneus CMCCB10104 (MIC 19.5 ug/ml), B. megat

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 19.5 µg/mL

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 19.5 ug/ml), S. aureus ATCC2592 (MIC 19.5 ug/ml), B. pyocyaneus CMCCB10104 (MIC 19.5 ug/ml), B. megatherium (MIC 19.5 ug/ml), B. dysenteri

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 19.5 µg/mL

Target

Target Organism B. pyocyaneus CMCCB10104

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 19.5 µg/mL

Target

Target Organism B. megatherium

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.7 µg/mL

Target

Target Organism B. dysenterium

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 9 µg/mL

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source DRAMP

Other

Evidence Text

herium (MIC 19.5 ug/ml), B. dysenterium (MIC 2.7 ug/ml), K. pneumoniae (MIC 9 ug/ml), and C. albicans ATCC2002 (MIC 3 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND).

Evidence 22 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:11835991]Little hemolytic activity at 50 µg/ml against red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Eur J Immunol. 2005 Apr 35(4):1220-9.##Peptides. 2002 Mar 23(3):427-435.