TPDB10956

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.6 µM

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E.coli ATCC25922 (ND), S. aureus ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 1

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7.2 µM

Target

Target Organism B. pyocyaneus CMCCB10104

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E.coli ATCC25922 (ND), S. aureus ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. a

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12 µM

Target

Target Organism B. megatherium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

li ATCC25922 (ND), S. aureus ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12 µM

Target

Target Organism B. dysenterium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 1

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.6 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFF

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.2 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFFI2001 (MIC 12 ug/ml). active only a

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12 µg/mL

Target

Target Organism A. flavus IFFI4015

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFFI2001 (MIC 12 ug/ml). active only against cancer cells C8166 (IC50 34.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12 µg/mL

Target

Target Organism P. uticale IFFI2001

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

e (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFFI2001 (MIC 12 ug/ml). active only against cancer cells C8166 (IC50 34.4 ug/ml) but not other cancer cell lines

Evidence 9 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=34.4 µg/ml

Detail Source Activity Anticancer

Activity Measurement 34.4 µg/mL

Target

Cancer Type Leukemia Cancer

Cell Line C8166

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.

Evidence 10 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 >50 µg/ml

Detail Source Activity Anticancer

Activity Measurement 50 µg/mL

Target

Cancer Type Leukemia Cancer

Cell Line MOLT-4

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001

Evidence 11 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 =>50 µg/ml

Detail Source Activity Anticancer

Activity Measurement >50 µg/mL

Target

Cancer Type Bladder Cancer

Cell Line BIU-87

Tissue Affected Bladder

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001

Evidence 12 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=>50 µg/ml

Detail Source Activity Anticancer

Activity Measurement >50 µg/mL

Target

Cancer Type Bladder Cancer

Cell Line T-24

Tissue Affected Bladder

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.6 µM

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E.coli ATCC25922 (ND), S. aureus ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 1

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7.2 µM

Target

Target Organism B. pyocyaneus CMCCB10104

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E.coli ATCC25922 (ND), S. aureus ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. a

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12 µM

Target

Target Organism B. megatherium

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

li ATCC25922 (ND), S. aureus ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12 µM

Target

Target Organism B. dysenterium

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 1

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.6 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFF

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.2 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFFI2001 (MIC 12 ug/ml). active only a

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12 µg/mL

Target

Target Organism A. flavus IFFI4015

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFFI2001 (MIC 12 ug/ml). active only against cancer cells C8166 (IC50 34.

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12 µg/mL

Target

Target Organism P. uticale IFFI2001

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

e (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFFI2001 (MIC 12 ug/ml). active only against cancer cells C8166 (IC50 34.4 ug/ml) but not other cancer cell lines

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.6 µM

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

Active against E.coli ATCC25922 (ND), S. aureus ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 1

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 7.2 µM

Target

Target Organism B. pyocyaneus CMCCB10104

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against E.coli ATCC25922 (ND), S. aureus ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. a

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12 µM

Target

Target Organism B. megatherium

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

li ATCC25922 (ND), S. aureus ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12 µM

Target

Target Organism B. dysenterium

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 1

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.6 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

ocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFF

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.2 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFFI2001 (MIC 12 ug/ml). active only a

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12 µg/mL

Target

Target Organism A. flavus IFFI4015

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFFI2001 (MIC 12 ug/ml). active only against cancer cells C8166 (IC50 34.

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12 µg/mL

Target

Target Organism P. uticale IFFI2001

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

e (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFFI2001 (MIC 12 ug/ml). active only against cancer cells C8166 (IC50 34.4 ug/ml) but not other cancer cell lines

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3.6 µM

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

Active against E.coli ATCC25922 (ND), S. aureus ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 1

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 7.2 µM

Target

Target Organism B. pyocyaneus CMCCB10104

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

Active against E.coli ATCC25922 (ND), S. aureus ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. a

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12 µM

Target

Target Organism B. megatherium

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

li ATCC25922 (ND), S. aureus ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12 µM

Target

Target Organism B. dysenterium

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

ATCC2592 (MIC3.6 uM), B. pyocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 1

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3.6 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

ocyaneus CMCCB10104 (MIC 7.2 uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFF

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.2 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

uM), B. megatherium (MIC 12 uM), B. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFFI2001 (MIC 12 ug/ml). active only a

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12 µg/mL

Target

Target Organism A. flavus IFFI4015

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

. dysenterium (MIC 12 uM), K. pneumoniae (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFFI2001 (MIC 12 ug/ml). active only against cancer cells C8166 (IC50 34.

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12 µg/mL

Target

Target Organism P. uticale IFFI2001

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

e (MIC 3.6 uM), C. albicans ATCC2002 (MIC 1.2 uM), A. flavus IFFI4015 (MIC 12 ug/ml), and P. uticale IFFI2001 (MIC 12 ug/ml). active only against cancer cells C8166 (IC50 34.4 ug/ml) but not other cancer cell lines

Evidence 37 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:11835991]Little hemolytic activity at 50 µg/ml against red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Eur J Immunol. 2005 Apr 35(4):1220-9.##Peptides. 2002 Mar 23(3):427-435.