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Peptide record

TPDB10948

Maximin 4 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10948
Maximin 4
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 AI4AVP DRAVP 2.0
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIGGVLLSAGKAALKGLAKVLAEKYAN
Physicochemical Analysis
C119H206N32O33
RDCQHMFPTW
A
2613.14
10.31
4
1
15
+3
1.65
0.593
130.37
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
57.02
3
Residue Composition
number
6
A
0
R
1
N
0
D
0
C
1
E
0
Q
5
G
0
H
1
I
5
L
4
K
0
M
0
F
0
P
1
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 6 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 5 H: 0 I: 1 L: 5 K: 4 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
27
C119H206N32O33
2613.14
10.31
+3
1.65
0.593
Free
L
Not Available
Free
Anticancer
Bombina maxima
Evidence Records 30 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.7 µM

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC25922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (
Evidence 2 Activity

Activity

MIC
Antibacterial
2.7 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC25922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC
Evidence 3 Activity

Activity

MIC
Antibacterial
2.7 µM

Target

B. pyocyaneus CMCCB10104

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC25922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C.
Evidence 4 Activity

Activity

MIC
Antibacterial
1.5 µM

Target

B. megatherium

Source & Reference

dbAMP DRAMP

Other

922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM)
Evidence 5 Activity

Activity

MIC
Antibacterial
2.7 µM

Target

B. dysenterium

Source & Reference

dbAMP DRAMP

Other

TCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and
Evidence 6 Activity

Activity

MIC
Antibacterial
15 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

yaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND). a
Evidence 7 Activity

Activity

MIC
Antibacterial
15 µM

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP

Other

uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND). active against cancer cells C8166 a
Evidence 8 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2002

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 9 Activity

Activity

MIC
Antifungal
2.7 µM

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC25922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (
Evidence 10 Activity

Activity

MIC
Antifungal
2.7 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC25922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC
Evidence 11 Activity

Activity

MIC
Antifungal
2.7 µM

Target

B. pyocyaneus CMCCB10104

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC25922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C.
Evidence 12 Activity

Activity

MIC
Antifungal
1.5 µM

Target

B. megatherium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM)
Evidence 13 Activity

Activity

MIC
Antifungal
2.7 µM

Target

B. dysenterium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

TCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and
Evidence 14 Activity

Activity

MIC
Antifungal
15 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

yaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND). a
Evidence 15 Activity

Activity

MIC
Antifungal
15 µM

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND). active against cancer cells C8166 a
Evidence 16 Activity

Activity

MIC
Antiparasitic
2.7 µM

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against E. coli ATCC25922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (
Evidence 17 Activity

Activity

MIC
Antiparasitic
2.7 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E. coli ATCC25922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC
Evidence 18 Activity

Activity

MIC
Antiparasitic
2.7 µM

Target

B. pyocyaneus CMCCB10104

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E. coli ATCC25922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C.
Evidence 19 Activity

Activity

MIC
Antiparasitic
1.5 µM

Target

B. megatherium

Source & Reference

dbAMP 3.0 DRAMP

Other

922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM)
Evidence 20 Activity

Activity

MIC
Antiparasitic
2.7 µM

Target

B. dysenterium

Source & Reference

dbAMP 3.0 DRAMP

Other

TCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and
Evidence 21 Activity

Activity

MIC
Antiparasitic
15 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP 3.0 DRAMP

Other

yaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND). a
Evidence 22 Activity

Activity

MIC
Antiparasitic
15 µM

Target

Candida albicans ATCC2002

Source & Reference

dbAMP 3.0 DRAMP

Other

uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND). active against cancer cells C8166 a
Evidence 23 Activity

Activity

MIC
Antiviral
2.7 µM

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against E. coli ATCC25922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (
Evidence 24 Activity

Activity

MIC
Antiviral
2.7 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against E. coli ATCC25922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC
Evidence 25 Activity

Activity

MIC
Antiviral
2.7 µM

Target

B. pyocyaneus CMCCB10104

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against E. coli ATCC25922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C.
Evidence 26 Activity

Activity

MIC
Antiviral
1.5 µM

Target

B. megatherium

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

922 (MIC 2.7 uM), S. aureus ATCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM)
Evidence 27 Activity

Activity

MIC
Antiviral
2.7 µM

Target

B. dysenterium

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

TCC2592 (MIC 2.7 uM), B. pyocyaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and
Evidence 28 Activity

Activity

MIC
Antiviral
15 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

yaneus CMCCB10104 (MIC 2.7 uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND). a
Evidence 29 Activity

Activity

MIC
Antiviral
15 µM

Target

Candida albicans ATCC2002

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

uM), B. megatherium (MIC 1.5 uM), B. dysenterium (MIC 2.7 uM), K. pneumoniae (MIC 15 uM), C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND). active against cancer cells C8166 a
Evidence 30 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:11835991]Little hemolytic activity at 50 µg/ml against red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Immunol. 2005 Apr 35(4):1220-9.##Peptides. 2002 Mar 23(3):427-435.