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Peptide record

TPDB10947

BMAP-27 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10947
BMAP-27
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP AI4AVP AVPpred-BWR DRAVP 2.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GRFKRFRKKFKKLFKKLSPVIPLLHLG
Physicochemical Analysis
C160H265N45O29
ANDCEQMTWY
K
3283.15
12.73
11
0
11
+10
3.81
-0.367
97.41
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
2
G
1
H
1
I
5
L
7
K
0
M
4
F
2
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 1 L: 5 K: 7 M: 0 F: 4 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
27
C160H265N45O29
3283.15
12.73
+10
3.81
-0.367
Free
L
Not Available
Free
Antibacterial
CowBos taurus
Evidence Records 42 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5-1 µM

Target

Escherichia coli ATCC 25922 ML-35 or D21

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcesce
Evidence 2 Activity

Activity

MIC
Antibacterial
1-2 µM

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC
Evidence 3 Activity

Activity

MIC
Antibacterial
1 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

t E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µM

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP DRAMP

Other

C 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM),
Evidence 5 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Staphylococcus aureus ATCC 25923 or Cowan 1 MRSA

Source & Reference

dbAMP DRAMP

Other

28 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8
Evidence 6 Activity

Activity

MIC
Antibacterial
1 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP

Other

), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Ant
Evidence 7 Activity

Activity

MIC
Antibacterial
2 µM

Target

B. megaterium Bm11

Source & Reference

dbAMP DRAMP

Other

S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Antibiofilm:bacteria: inhibited ba
Evidence 8 Activity

Activity

MIC
Antibacterial
8 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Antibiofilm:bacteria: inhibited bacterial biofilm:S. malto
Evidence 9 Activity

Activity

MIC
Antibacterial
4 µM

Target

C. neoformans

Source & Reference

dbAMP DRAMP

Other

ermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Antibiofilm:bacteria: inhibited bacterial biofilm:S. maltophilia (0.5 MIC) nhibited bac
Evidence 10 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
1996

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 11 Activity

Activity

MIC
Antifungal
0.5-1 µM

Target

Escherichia coli ATCC 25922 ML-35 or D21

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcesce
Evidence 12 Activity

Activity

MIC
Antifungal
1-2 µM

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC
Evidence 13 Activity

Activity

MIC
Antifungal
1 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

t E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S
Evidence 14 Activity

Activity

MIC
Antifungal
2 µM

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM),
Evidence 15 Activity

Activity

MIC
Antifungal
2-4 µM

Target

Staphylococcus aureus ATCC 25923 or Cowan 1 MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

28 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8
Evidence 16 Activity

Activity

MIC
Antifungal
1 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Ant
Evidence 17 Activity

Activity

MIC
Antifungal
2 µM

Target

B. megaterium Bm11

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Antibiofilm:bacteria: inhibited ba
Evidence 18 Activity

Activity

MIC
Antifungal
8 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Antibiofilm:bacteria: inhibited bacterial biofilm:S. malto
Evidence 19 Activity

Activity

MIC
Antifungal
4 µM

Target

C. neoformans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Antibiofilm:bacteria: inhibited bacterial biofilm:S. maltophilia (0.5 MIC) nhibited bac
Evidence 20 Activity

Activity

MIC
Antiparasitic
0.5-1 µM

Target

Escherichia coli ATCC 25922 ML-35 or D21

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcesce
Evidence 21 Activity

Activity

MIC
Antiparasitic
1-2 µM

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC
Evidence 22 Activity

Activity

MIC
Antiparasitic
1 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0 DRAMP

Other

t E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S
Evidence 23 Activity

Activity

MIC
Antiparasitic
2 µM

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP 3.0 DRAMP

Other

C 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM),
Evidence 24 Activity

Activity

MIC
Antiparasitic
2-4 µM

Target

Staphylococcus aureus ATCC 25923 or Cowan 1 MRSA

Source & Reference

dbAMP 3.0 DRAMP

Other

28 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8
Evidence 25 Activity

Activity

MIC
Antiparasitic
1 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP 3.0 DRAMP

Other

), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Ant
Evidence 26 Activity

Activity

MIC
Antiparasitic
2 µM

Target

B. megaterium Bm11

Source & Reference

dbAMP 3.0 DRAMP

Other

S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Antibiofilm:bacteria: inhibited ba
Evidence 27 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Candida albicans

Source & Reference

dbAMP 3.0 DRAMP

Other

1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Antibiofilm:bacteria: inhibited bacterial biofilm:S. malto
Evidence 28 Activity

Activity

MIC
Antiparasitic
4 µM

Target

C. neoformans

Source & Reference

dbAMP 3.0 DRAMP

Other

ermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Antibiofilm:bacteria: inhibited bacterial biofilm:S. maltophilia (0.5 MIC) nhibited bac
Evidence 29 Activity

Activity

MIC
Antiviral
0.5-1 µM

Target

Escherichia coli ATCC 25922 ML-35 or D21

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcesce
Evidence 30 Activity

Activity

MIC
Antiviral
1-2 µM

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC
Evidence 31 Activity

Activity

MIC
Antiviral
1 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

t E. coli ATCC 25922 ML-35 or D21 (MIC 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S
Evidence 32 Activity

Activity

MIC
Antiviral
2 µM

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

C 0.5-1 uM), S. typhimurium ATCC 14028 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM),
Evidence 33 Activity

Activity

MIC
Antiviral
2-4 µM

Target

Staphylococcus aureus ATCC 25923 or Cowan 1 MRSA

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

28 (MIC 1-2 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8
Evidence 34 Activity

Activity

MIC
Antiviral
1 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

), S. marcescens ATCC 8100 (MIC 2 uM), S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Ant
Evidence 35 Activity

Activity

MIC
Antiviral
2 µM

Target

B. megaterium Bm11

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

S. aureus ATCC 25923 or Cowan 1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Antibiofilm:bacteria: inhibited ba
Evidence 36 Activity

Activity

MIC
Antiviral
8 µM

Target

Candida albicans

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

1 MRSA (MIC 2-4 uM), S. epidermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Antibiofilm:bacteria: inhibited bacterial biofilm:S. malto
Evidence 37 Activity

Activity

MIC
Antiviral
4 µM

Target

C. neoformans

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ermidis ATCC 12228 (MIC 1 uM), B. megaterium Bm11 (MIC 2 uM), C. albicans (MIC 8 uM), and C. neoformans (MIC 4 uM). Antibiofilm:bacteria: inhibited bacterial biofilm:S. maltophilia (0.5 MIC) nhibited bac
Evidence 38 Activity

Activity

50% Hemolysis
Toxicity
>>250 µM
Hemolytic Cytotoxic
50% Hemolysis | >>250 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-antimicrobial Peptides: Folding-Mediated Host Defense Antagonists | J Biol Chem | 2013
Evidence 39 Activity

Activity

10% Hemolysis
Toxicity
6.2 µM
Hemolytic Cytotoxic
10% Hemolysis | 6.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cell selectivity, mechanism of action and LPS-neutralizing activity of bovine myeloid antimicrobial peptide-18 (BMAP-18) and its analogs. | Peptides | 2011
Evidence 40 Activity

Activity

4% Hemolysis
Toxicity
3 µM
Hemolytic Cytotoxic
4% Hemolysis | 3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. | J Biol Chem | 1996
Evidence 41 Activity

Activity

33% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
33% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. | J Biol Chem | 1996
Evidence 42 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.