TPDB

3D PDB MODEL

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TPDB ID TPDB10946

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GFLGPLLKLAAKGVAKVIPHLIPSRQQ

FASTA

>TPDB10946|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=27
GFLGPLLKLAAKGVAKVIPHLIPSRQQ

Formula C134H227N37O31

Absent Amino Acids NDCEMTWY

Common Amino Acids L

Mass 2852.51

PI 11.73

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 13

Net Charge +4

Boman Index 2.49

Hydrophobicity 0.422

Aliphatic Index 133.70

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

3

A

1

R

0

N

0

D

0

C

0

E

2

Q

3

G

1

H

2

I

5

L

3

K

0

M

1

F

3

P

1

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 3 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 3 H: 1 I: 2 L: 5 K: 3 M: 0 F: 1 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 2

Length

27

Formula

C134H227N37O31

Mass

2852.51

PI

11.73

Net Charge

+4

Boman Index

2.49

Hydrophobicity

0.422

Evidence 1 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Hemolysis

Activity Measurement 90 µM

Hemolysis Raw

[Ref.11738090]HC50=90 µM against human erythrocytes

Target

RBC Target human erythrocytes

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

Biochim Biophys Acta. 2001 Nov 26 1550(1):81-89.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 90 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 90 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae). | Biochim Biophys Acta | 2001

Evidence 3 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Toxicity

Activity Measurement 90 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.11738090]HC50=90 µM against human erythrocytes

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biochim Biophys Acta. 2001 Nov 26 1550(1):81-89.

Evidence 4 Hemolysis

Activity

Activity Measurement 90 µM

Activity Endpoint HC50

Hemolysis Raw

[Ref.11738090]HC50=90 µM against human erythrocytes

Detail Source Activity Hemolysis

Target

RBC Target human erythrocytes

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Reference

Biochim Biophys Acta. 2001 Nov 26 1550(1):81-89.

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.