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Peptide record

TPDB10945

Antibacterial Hemolysis Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB10945
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLFDIIKKIAESFKFSEAIKKIIDFLG
Physicochemical Analysis
C148H236N32O38
RNCQHMPTWYV
I
3071.69
9.60
5
4
14
+1
3.89
0.500
122.96
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
0
R
0
N
2
D
0
C
2
E
0
Q
2
G
0
H
6
I
2
L
5
K
0
M
4
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 2 C: 0 E: 2 Q: 0 G: 2 H: 0 I: 6 L: 2 K: 5 M: 0 F: 4 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
27
C148H236N32O38
3071.69
9.60
+1
3.89
0.500
Evidence Records 3 records
Evidence 1 Activity

Activity

30% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
30% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dimerization of aurein 1.2: effects in structure, antimicrobial activity and aggregation of Candida albicans cells. | Amino Acids | 2013
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
30 %
Hemolytic
Hemolytic_activity: [Ref.23519707]~30% hemolysis at 32µmol/L, 10% hemolysis at 4 µmol/L against human red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2013 Jun 44(6):1521-8.
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis