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Peptide record

TPDB10939

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB10939
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GVFGLLAKAALKGASKLIPHLLPSRQQ
Physicochemical Analysis
C130H221N37O32
NDCEMTWY
L
2814.41
11.73
5
0
13
+4
1.68
0.337
126.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
4
A
1
R
0
N
0
D
0
C
0
E
2
Q
3
G
1
H
1
I
6
L
3
K
0
M
1
F
2
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 3 H: 1 I: 1 L: 6 K: 3 M: 0 F: 1 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
27
C130H221N37O32
2814.41
11.73
+4
1.68
0.337
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S.
Evidence 2 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 16 uM), and
Evidence 3 Activity

Activity

MIC
Antibacterial
1 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 16 uM), and parasite T. brucei (LC95 1-
Evidence 4 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

M. luteus

Source & Reference

dbAMP

Other

against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 16 uM), and parasite T. brucei (LC95 1-2 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
16 µM

Target

S. cerevisiae

Source & Reference

dbAMP

Other

M), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 16 uM), and parasite T. brucei (LC95 1-2 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
1 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S.
Evidence 7 Activity

Activity

MIC
Antifungal
4-8 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 16 uM), and
Evidence 8 Activity

Activity

MIC
Antifungal
1 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 16 uM), and parasite T. brucei (LC95 1-
Evidence 9 Activity

Activity

MIC
Antifungal
0.5 µM

Target

M. luteus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 16 uM), and parasite T. brucei (LC95 1-2 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
16 µM

Target

S. cerevisiae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

M), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 16 uM), and parasite T. brucei (LC95 1-2 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
1 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S.
Evidence 12 Activity

Activity

MIC
Antiparasitic
4-8 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 16 uM), and
Evidence 13 Activity

Activity

MIC
Antiparasitic
1 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 16 uM), and parasite T. brucei (LC95 1-
Evidence 14 Activity

Activity

MIC
Antiparasitic
0.5 µM

Target

M. luteus

Source & Reference

dbAMP 3.0

Other

against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 16 uM), and parasite T. brucei (LC95 1-2 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
16 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0

Other

M), P. aeruginosa (MIC 4-8 uM), Gram+ S. aureus (MIC 1 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 16 uM), and parasite T. brucei (LC95 1-2 uM).
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
50% Hemolysis | 64 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 17 Activity

Activity

IC50
Toxicity
8 µM
Cytotoxic
IC50 | 8 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 18 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.