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Peptide record

TPDB10938

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB10938
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP dbAMP 3.0 iACP-DRLF CAFPdb i2APP
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KILRGVCKKIMRTFLRRISKDILTGKK
Physicochemical Analysis
C143H261N45O33S2
ANEQHPWY
K
3203.05
12.02
10
1
10
+9
6.39
-0.263
111.85
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
0
A
4
R
0
N
1
D
1
C
0
E
0
Q
2
G
0
H
4
I
3
L
6
K
1
M
1
F
0
P
1
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 4 L: 3 K: 6 M: 1 F: 1 P: 0 S: 1 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
27
C143H261N45O33S2
3203.05
12.02
+9
6.39
-0.263
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens. | J Biol Chem | 2007
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
281±48 µM
Hemolytic Cytotoxic
50% Hemolysis | 281±48 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Designing Anticancer Peptides by Constructive Machine Learning. | ChemMedChem | 2018
Evidence 3 Activity

Activity

33% Hemolysis
Toxicity
75 µM
Hemolytic Cytotoxic
33% Hemolysis | 75 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Influence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2. | Probiotics Antimicrob Proteins | 2018
Evidence 4 Activity

Activity

IC50
Toxicity
25.1 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.29043494] 2.5% hemolysis at 10 µg/ml , 8% hemolysis at 25 µg/ml , 22% hemolysis at 50 µg/ml , 32.5% hemolysis at 75 µg/ml , 36% hemolysis at 150 µg/ml , 38% hemolysis at 300 µg/ml against human red blood cells | Cytotoxicity: [Ref.29043494] IC50 = 25.1 µM against NK-2. ##IC50 = 8.4 µM against EJ. ##IC50 = 4.1 µM against PC-3. ##IC50 = 10.1 µM against T24. ##IC50 = 13.7 µM against HL-60. ##The proliferation inhibition activity on K562 is not significant.

Target

erythrocytes

Source & Reference

NA
DRAMP
Probiotics Antimicrob Proteins. 2018 Mar 10(1):118-127. doi: 10.1007/s12602-017-9335-1.