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Peptide record

TPDB10936

Antibacterial Anticancer Antifungal Antiparasitic standard
27 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10936
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
AntiBP3 Peptipedia ACP740 _ACP240 AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
Sequence
KRRHWFPLSFQEFLEQLRRFRDQLPFP
Physicochemical Analysis
C169H249N49O38
ANCGIMTYV
RF
3575.14
11.83
7
3
10
+3
4.75
-1.033
57.78
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
153.84
4
Residue Composition
number
0
A
5
R
0
N
1
D
0
C
2
E
3
Q
0
G
1
H
0
I
4
L
1
K
0
M
5
F
3
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 1 C: 0 E: 2 Q: 3 G: 0 H: 1 I: 0 L: 4 K: 1 M: 0 F: 5 P: 3 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
27
C169H249N49O38
3575.14
11.83
+3
4.75
-1.033
Evidence Records 39 records
Evidence 1 Activity

Activity

MIC
Antibacterial
14 µg/mL

Target

Escherichia coli ATCC 25922 or ML 35

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against a broad range of bacteria E. coli ATCC 25922 or ML 35 (MIC 14 ug/ml), S. marcescens ATCC 8100 (MIC 28.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 28.5 ug/m
Evidence 2 Activity

Activity

MIC
Antibacterial
28.5 µg/mL

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP

Other

active against a broad range of bacteria E. coli ATCC 25922 or ML 35 (MIC 14 ug/ml), S. marcescens ATCC 8100 (MIC 28.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 28.5 ug/ml or 114 ug/ml), S. aureus ATCC 25923 or M
Evidence 3 Activity

Activity

MIC
Antibacterial
57-114 µg/mL

Target

Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

dbAMP

Other

TCC 8100 (MIC 28.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 28.5 ug/ml or 114 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 57-114 ug/ml), S. epidermidis ATCC 12228 (MIC 28.5 ug/ml), and B. megaterium Bm11 (MIC 14 ug/ml). Fungi
Evidence 4 Activity

Activity

MIC
Antibacterial
28.5 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP

Other

83 or SK1 (MIC 28.5 ug/ml or 114 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 57-114 ug/ml), S. epidermidis ATCC 12228 (MIC 28.5 ug/ml), and B. megaterium Bm11 (MIC 14 ug/ml). Fungi: inactive against fungi various C.neoforman
Evidence 5 Activity

Activity

MIC
Antibacterial
14 µg/mL

Target

B. megaterium Bm11

Source & Reference

dbAMP

Other

us ATCC 25923 or MRSA (MIC 57-114 ug/ml), S. epidermidis ATCC 12228 (MIC 28.5 ug/ml), and B. megaterium Bm11 (MIC 14 ug/ml). Fungi: inactive against fungi various C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 u
Evidence 6 Activity

Activity

MIC
Antibacterial
>114 µg/mL

Target

C.neoformans

Source & Reference

dbAMP

Other

28.5 ug/ml), and B. megaterium Bm11 (MIC 14 ug/ml). Fungi: inactive against fungi various C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.t
Evidence 7 Activity

Activity

MIC
Antibacterial
>114 µg/mL

Target

R.rubra

Source & Reference

dbAMP

Other

Bm11 (MIC 14 ug/ml). Fungi: inactive against fungi various C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml),
Evidence 8 Activity

Activity

MIC
Antibacterial
>114 µg/mL

Target

C.albicans

Source & Reference

dbAMP

Other

: inactive against fungi various C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml), and P.etchellsii (MIC>114 u
Evidence 9 Activity

Activity

MIC
Antibacterial
>114 µg/mL

Target

C.parapsilosis

Source & Reference

dbAMP

Other

rious C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml), and P.etchellsii (MIC>114 ug/ml) in Sabouraud medium. Howe
Evidence 10 Activity

Activity

MIC
Antibacterial
>114 µg/mL

Target

C.tropicalis

Source & Reference

dbAMP

Other

ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml), and P.etchellsii (MIC>114 ug/ml) in Sabouraud medium. However, active against C. neoform
Evidence 11 Activity

Activity

MIC
Antibacterial
>114 µg/mL

Target

P.etchellsii

Source & Reference

dbAMP

Other

lbicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml), and P.etchellsii (MIC>114 ug/ml) in Sabouraud medium. However, active against C. neoformans (MIC 21-28.5 ug/ml), R.rubra (
Evidence 12 Activity

Activity

MIC
Antibacterial
21-28.5 µg/mL

Target

C. neoformans

Source & Reference

dbAMP

Other

114 ug/ml), and P.etchellsii (MIC>114 ug/ml) in Sabouraud medium. However, active against C. neoformans (MIC 21-28.5 ug/ml), R.rubra (MIC 57 ug/ml) in RPMI ( Skerlavaj B et al., 2001 ).
Evidence 13 Activity

Activity

MIC
Antibacterial
57 µg/mL

Target

R.rubra

Source & Reference

dbAMP

Other

14 ug/ml) in Sabouraud medium. However, active against C. neoformans (MIC 21-28.5 ug/ml), R.rubra (MIC 57 ug/ml) in RPMI ( Skerlavaj B et al., 2001 ).
Evidence 14 Activity

Activity

MIC
Antifungal
14 µg/mL

Target

Escherichia coli ATCC 25922 or ML 35

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against a broad range of bacteria E. coli ATCC 25922 or ML 35 (MIC 14 ug/ml), S. marcescens ATCC 8100 (MIC 28.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 28.5 ug/m
Evidence 15 Activity

Activity

MIC
Antifungal
28.5 µg/mL

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against a broad range of bacteria E. coli ATCC 25922 or ML 35 (MIC 14 ug/ml), S. marcescens ATCC 8100 (MIC 28.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 28.5 ug/ml or 114 ug/ml), S. aureus ATCC 25923 or M
Evidence 16 Activity

Activity

MIC
Antifungal
57-114 µg/mL

Target

Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

dbAMP CAFPdb Antifungipept

Other

TCC 8100 (MIC 28.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 28.5 ug/ml or 114 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 57-114 ug/ml), S. epidermidis ATCC 12228 (MIC 28.5 ug/ml), and B. megaterium Bm11 (MIC 14 ug/ml). Fungi
Evidence 17 Activity

Activity

MIC
Antifungal
28.5 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP CAFPdb Antifungipept

Other

83 or SK1 (MIC 28.5 ug/ml or 114 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 57-114 ug/ml), S. epidermidis ATCC 12228 (MIC 28.5 ug/ml), and B. megaterium Bm11 (MIC 14 ug/ml). Fungi: inactive against fungi various C.neoforman
Evidence 18 Activity

Activity

MIC
Antifungal
14 µg/mL

Target

B. megaterium Bm11

Source & Reference

dbAMP CAFPdb Antifungipept

Other

us ATCC 25923 or MRSA (MIC 57-114 ug/ml), S. epidermidis ATCC 12228 (MIC 28.5 ug/ml), and B. megaterium Bm11 (MIC 14 ug/ml). Fungi: inactive against fungi various C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 u
Evidence 19 Activity

Activity

MIC
Antifungal
>114 µg/mL

Target

C.neoformans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

28.5 ug/ml), and B. megaterium Bm11 (MIC 14 ug/ml). Fungi: inactive against fungi various C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.t
Evidence 20 Activity

Activity

MIC
Antifungal
>114 µg/mL

Target

R.rubra

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Bm11 (MIC 14 ug/ml). Fungi: inactive against fungi various C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml),
Evidence 21 Activity

Activity

MIC
Antifungal
>114 µg/mL

Target

C.albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

: inactive against fungi various C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml), and P.etchellsii (MIC>114 u
Evidence 22 Activity

Activity

MIC
Antifungal
>114 µg/mL

Target

C.parapsilosis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

rious C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml), and P.etchellsii (MIC>114 ug/ml) in Sabouraud medium. Howe
Evidence 23 Activity

Activity

MIC
Antifungal
>114 µg/mL

Target

C.tropicalis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml), and P.etchellsii (MIC>114 ug/ml) in Sabouraud medium. However, active against C. neoform
Evidence 24 Activity

Activity

MIC
Antifungal
>114 µg/mL

Target

P.etchellsii

Source & Reference

dbAMP CAFPdb Antifungipept

Other

lbicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml), and P.etchellsii (MIC>114 ug/ml) in Sabouraud medium. However, active against C. neoformans (MIC 21-28.5 ug/ml), R.rubra (
Evidence 25 Activity

Activity

MIC
Antifungal
21-28.5 µg/mL

Target

C. neoformans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

114 ug/ml), and P.etchellsii (MIC>114 ug/ml) in Sabouraud medium. However, active against C. neoformans (MIC 21-28.5 ug/ml), R.rubra (MIC 57 ug/ml) in RPMI ( Skerlavaj B et al., 2001 ).
Evidence 26 Activity

Activity

MIC
Antifungal
57 µg/mL

Target

R.rubra

Source & Reference

dbAMP CAFPdb Antifungipept

Other

14 ug/ml) in Sabouraud medium. However, active against C. neoformans (MIC 21-28.5 ug/ml), R.rubra (MIC 57 ug/ml) in RPMI ( Skerlavaj B et al., 2001 ).
Evidence 27 Activity

Activity

MIC
Antiparasitic
14 µg/mL

Target

Escherichia coli ATCC 25922 or ML 35

Source & Reference

NA

Other

active against a broad range of bacteria E. coli ATCC 25922 or ML 35 (MIC 14 ug/ml), S. marcescens ATCC 8100 (MIC 28.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 28.5 ug/m
Evidence 28 Activity

Activity

MIC
Antiparasitic
28.5 µg/mL

Target

S. marcescens ATCC 8100

Source & Reference

NA

Other

active against a broad range of bacteria E. coli ATCC 25922 or ML 35 (MIC 14 ug/ml), S. marcescens ATCC 8100 (MIC 28.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 28.5 ug/ml or 114 ug/ml), S. aureus ATCC 25923 or M
Evidence 29 Activity

Activity

MIC
Antiparasitic
57-114 µg/mL

Target

Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

NA

Other

TCC 8100 (MIC 28.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 28.5 ug/ml or 114 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 57-114 ug/ml), S. epidermidis ATCC 12228 (MIC 28.5 ug/ml), and B. megaterium Bm11 (MIC 14 ug/ml). Fungi
Evidence 30 Activity

Activity

MIC
Antiparasitic
28.5 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

NA

Other

83 or SK1 (MIC 28.5 ug/ml or 114 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 57-114 ug/ml), S. epidermidis ATCC 12228 (MIC 28.5 ug/ml), and B. megaterium Bm11 (MIC 14 ug/ml). Fungi: inactive against fungi various C.neoforman
Evidence 31 Activity

Activity

MIC
Antiparasitic
14 µg/mL

Target

B. megaterium Bm11

Source & Reference

NA

Other

us ATCC 25923 or MRSA (MIC 57-114 ug/ml), S. epidermidis ATCC 12228 (MIC 28.5 ug/ml), and B. megaterium Bm11 (MIC 14 ug/ml). Fungi: inactive against fungi various C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 u
Evidence 32 Activity

Activity

MIC
Antiparasitic
>114 µg/mL

Target

C.neoformans

Source & Reference

NA

Other

28.5 ug/ml), and B. megaterium Bm11 (MIC 14 ug/ml). Fungi: inactive against fungi various C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.t
Evidence 33 Activity

Activity

MIC
Antiparasitic
>114 µg/mL

Target

R.rubra

Source & Reference

NA

Other

Bm11 (MIC 14 ug/ml). Fungi: inactive against fungi various C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml),
Evidence 34 Activity

Activity

MIC
Antiparasitic
>114 µg/mL

Target

C.albicans

Source & Reference

NA

Other

: inactive against fungi various C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml), and P.etchellsii (MIC>114 u
Evidence 35 Activity

Activity

MIC
Antiparasitic
>114 µg/mL

Target

C.parapsilosis

Source & Reference

NA

Other

rious C.neoformans (MIC >114 ug/ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml), and P.etchellsii (MIC>114 ug/ml) in Sabouraud medium. Howe
Evidence 36 Activity

Activity

MIC
Antiparasitic
>114 µg/mL

Target

C.tropicalis

Source & Reference

NA

Other

ml), R.rubra (MIC >114 ug/ml), C.albicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml), and P.etchellsii (MIC>114 ug/ml) in Sabouraud medium. However, active against C. neoform
Evidence 37 Activity

Activity

MIC
Antiparasitic
>114 µg/mL

Target

P.etchellsii

Source & Reference

NA

Other

lbicans (MIC>114 ug/ml),C.parapsilosis (MIC>114 ug/ml), C.tropicalis (MIC>114 ug/ml), and P.etchellsii (MIC>114 ug/ml) in Sabouraud medium. However, active against C. neoformans (MIC 21-28.5 ug/ml), R.rubra (
Evidence 38 Activity

Activity

MIC
Antiparasitic
21-28.5 µg/mL

Target

C. neoformans

Source & Reference

NA

Other

114 ug/ml), and P.etchellsii (MIC>114 ug/ml) in Sabouraud medium. However, active against C. neoformans (MIC 21-28.5 ug/ml), R.rubra (MIC 57 ug/ml) in RPMI ( Skerlavaj B et al., 2001 ).
Evidence 39 Activity

Activity

MIC
Antiparasitic
57 µg/mL

Target

R.rubra

Source & Reference

NA

Other

14 ug/ml) in Sabouraud medium. However, active against C. neoformans (MIC 21-28.5 ug/ml), R.rubra (MIC 57 ug/ml) in RPMI ( Skerlavaj B et al., 2001 ).