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Peptide record

TPDB10933

Antibacterial Anticancer Antifungal Antiparasitic standard

27 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10933

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GFLGPLLKLGLKGVAKVLPHLIPSRQQ

FASTA

>TPDB10933|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=27
GFLGPLLKLGLKGVAKVLPHLIPSRQQ

Formula C136H231N37O31

Absent Amino Acids NDCEMTWY

Common Amino Acids L

Mass 2880.56

PI 11.73

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +4

Boman Index 2.03

Hydrophobicity 0.389

Aliphatic Index 140.74

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 4 H: 1 I: 1 L: 7 K: 3 M: 0 F: 1 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 2

Length

Formula

C136H231N37O31

Mass

2880.56

11.73

Net Charge

Boman Index

2.03

Hydrophobicity

0.389

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli (MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aerugino

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism A. baumannii

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C. albicans (MIC 25 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C. albicans (MIC 25 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C. albicans (MIC 25 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C. albicans (MIC 25 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli (MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aerugino

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µM

Target

Target Organism A. baumannii

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C. albicans (MIC 25 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C. albicans (MIC 25 uM).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C. albicans (MIC 25 uM).

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C. albicans (MIC 25 uM).

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli (MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aerugino

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C.

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12.5 µM

Target

Target Organism A. baumannii

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C. albicans (MIC 25 uM).

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C. albicans (MIC 25 uM).

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source DRAMP

Other

Evidence Text

(MIC 25 uM), S. aureus (MIC 6 uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C. albicans (MIC 25 uM).

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

uM), A. baumannii (MIC 12.5 uM), K. pneumoniae (MIC 25 uM), P. aeruginosa (MIC 6 uM), and C. albicans (MIC 25 uM).