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Peptide record

TPDB10931

Bacteriocin) Mutacin-2 (Mutacin II mutacin H-29B Antibacterial Anticancer Antifungal Antiparasitic Antimicrobial Anti-Gram+ Anti-Gram- standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB10931
Bacteriocin) Mutacin-2 (Mutacin II mutacin H-29B
Antibacterial Anticancer Antifungal Antiparasitic Antimicrobial Anti-Gram+ Anti-Gram-
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
NRWWQGVVPTVSYECRMNSWQHVFTCC
Physicochemical Analysis
C147H210N42O39S4
ADILK
V
3317.78
8.02
3
1
10
+1
-0.69
-0.359
42.96
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
18115
546.00
12
Residue Composition
number
0
A
2
R
2
N
0
D
3
C
1
E
2
Q
1
G
1
H
0
I
0
L
0
K
1
M
1
F
1
P
2
S
2
T
3
W
1
Y
4
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 0 C: 3 E: 1 Q: 2 G: 1 H: 1 I: 0 L: 0 K: 0 M: 1 F: 1 P: 1 S: 2 T: 2 W: 3 Y: 1 V: 4
Chemical Descriptors
27
C147H210N42O39S4
3317.78
8.02
+1
-0.69
-0.359
Evidence Records 2 records
Evidence 1 Activity

Source & Reference

dbAMP DRAMP Antifungipept
Evidence 2 Activity

Target

Cutibacterium acnes

Source & Reference

DRAMP
Krull RE, Chen P, Novak J, Kirk M, Barnes S, Baker J, Krishna NR, Caufield PW.##Chikindas ML, Nov¡k J, Driessen AJ, Konings WN, Schilling KM, Caufield PW.##Nicolas G, Morency H, LaPointe G, Lavoie MC.##Nov¡k J, Caufield PW, Miller EJ.
Biochemical structural analysis of the lantibiotic mutacin II.##Mutacin II, a bactericidal antibiotic from Streptococcus mutans.##Mutacin H-29B is identical to mutacin II (J-T8).##Isolation and biochemical characterization of a novel lantibiotic mutacin from Streptococcus mutans.
J Biol Chem. 2000 May 26 275(21):15845-15850.##Antimicrob Agents Chemother. 1995 Dec 39(12):2656-2660.##BMC Microbiol. 2006 Apr 20 6:36.##J Bacteriol. 1994 Jul 176(14):4316-4320.

Other

Source Activity Label Source Definition
Antimicrobial Antibacterial Anti-Gram+ Anti-Gram-
DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Streptococcus mutans (Gram-positive bacteria)
Belongs to the type A lantibiotic family (Class I bacteriocin)
Function: Mutacin-2 inhibits other mutans streptococci as well as many gram-positive exogenous pathogens. Transiently and partially depolarizes the transmembrane electrical potential and pH gradient of susceptible cells, inhibits the uptake of amino acids and depletes the intracellular ATP pool. Biophysicochemical properties: pH dependence (Stable from pH 4.0 to 10.0) Temperature dependence (Thermostable). PTM: There are one didehydrobutyrine (T25), two lanthionines (S12-C26 S19-C27) and one Beta-methyllanthionine (T10-C15).
Additional Detail Fields 1 fields
Belongs to the type A lantibiotic family (Class I bacteriocin)