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Peptide record

TPDB10925

Antibacterial Antifungal Hemolysis Toxicity standard

27 amino acids

3D PDB MODEL

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TPDB ID TPDB10925

Activity

Antibacterial Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept APD_complete PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 27-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

FFFHIIKGLFHAGRMIHGLVNRRRHRH

FASTA

>TPDB10925|Antibacterial;Antifungal;Hemolysis;Toxicity|length=27
FFFHIIKGLFHAGRMIHGLVNRRRHRH

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

Formula C155H238N54O29S1

Absent Amino Acids DCEQPSTWY

Common Amino Acids RH

Mass 3354.00

PI 13.00

Basic Residues 11

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +6

Boman Index 2.32

Hydrophobicity -0.256

Aliphatic Index 86.67

N-end Rule Half-life Estimate

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 1 R: 5 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 5 I: 3 L: 2 K: 1 M: 1 F: 4 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

27 reviewed residue count

Formula

C155H238N54O29S1 sequence-only estimate (linear, free termini)

Mass

3354.00 sequence-only estimate (linear, free termini)

13.00 sequence-only estimate (linear, free termini)

Net Charge

+6 sequence-only estimate (linear, free termini)

Boman Index

2.32 sequence-only estimate (linear, free termini)

Hydrophobicity

-0.256 sequence-only estimate (linear, free termini)

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.5 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 2.5 uM), and V. parahaemolyticus (MIC 2.5 uM). MBC values are the same as

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.5 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 2.5 uM), and V. parahaemolyticus (MIC 2.5 uM). MBC values are the same as MICs. UPdated 7/2021 6

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.5 µM

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 2.5 uM), and V. parahaemolyticus (MIC 2.5 uM). MBC values are the same as MICs. UPdated 7/2021 6/2025

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.5 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 2.5 uM), and V. parahaemolyticus (MIC 2.5 uM). MBC values are the same as

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.5 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 2.5 uM), and V. parahaemolyticus (MIC 2.5 uM). MBC values are the same as MICs. UPdated 7/2021 6

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.5 µM

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 2.5 uM), and V. parahaemolyticus (MIC 2.5 uM). MBC values are the same as MICs. UPdated 7/2021 6/2025

Evidence 7 Activity

Activity

Activity Endpoint 19% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 20 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

19% Hemolysis | 20 | µM | target cell: Fish erythrocytes

Target

Target Cell Fish erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Two isoforms of piscidin from Malabar grouper, Epinephelus malabaricus: Expression and functional characterization. | Fish Shellfish Immunol | 2016

Evidence 8 Activity

Activity

Activity Endpoint 75% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 20 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

75% Hemolysis | 20 | µM | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Two isoforms of piscidin from Malabar grouper, Epinephelus malabaricus: Expression and functional characterization. | Fish Shellfish Immunol | 2016

Evidence 9 Hemolysis

Source & Reference

source APD_complete PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.