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Peptide record

TPDB10892

Antibacterial Anticancer Antidiabetic Antifungal Hemolysis Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB10892
Antibacterial Anticancer Antidiabetic Antifungal Hemolysis Toxicity
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia SATPdb dbACP AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, SATPdb, and other sources, with an available 3D structural model.
Sequence
GIFPIFAKLLGKVIKVASSLISKGRTE
Physicochemical Analysis
C135H230N34O34
NDCQHMWY
IK
2873.52
10.98
5
1
13
+4
2.42
0.648
130.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
1
E
0
Q
3
G
0
H
4
I
3
L
4
K
0
M
2
F
1
P
3
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 4 L: 3 K: 4 M: 0 F: 2 P: 1 S: 3 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
27
C135H230N34O34
2873.52
10.98
+4
2.42
0.648
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5-10 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus (MIC 5-10 uM), S. epidermidis (MIC 2.5-10 uM), E. faecalis (MIC 20 um), A. baumannii (10-20 uM), S. mal
Evidence 2 Activity

Activity

MIC
Antibacterial
2.5-10 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP

Other

Active against S. aureus (MIC 5-10 uM), S. epidermidis (MIC 2.5-10 uM), E. faecalis (MIC 20 um), A. baumannii (10-20 uM), S. maltophilia (10-40 uM), E. coli (80
Evidence 3 Activity

Activity

MIC
Antibacterial
20 um

Target

Enterococcus faecalis

Source & Reference

dbAMP

Other

Active against S. aureus (MIC 5-10 uM), S. epidermidis (MIC 2.5-10 uM), E. faecalis (MIC 20 um), A. baumannii (10-20 uM), S. maltophilia (10-40 uM), E. coli (80 uM), P. aeruginosa (80 u
Evidence 4 Activity

Activity

MIC
Antibacterial
80 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

mannii (10-20 uM), S. maltophilia (10-40 uM), E. coli (80 uM), P. aeruginosa (80 uM), and C. albicans (MIC 80 uM). Toxic effects on cancer and normal cells: The peptide is also active against select canc
Evidence 5 Activity

Activity

MIC
Antifungal
5-10 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus (MIC 5-10 uM), S. epidermidis (MIC 2.5-10 uM), E. faecalis (MIC 20 um), A. baumannii (10-20 uM), S. mal
Evidence 6 Activity

Activity

MIC
Antifungal
2.5-10 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 5-10 uM), S. epidermidis (MIC 2.5-10 uM), E. faecalis (MIC 20 um), A. baumannii (10-20 uM), S. maltophilia (10-40 uM), E. coli (80
Evidence 7 Activity

Activity

MIC
Antifungal
20 um

Target

Enterococcus faecalis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 5-10 uM), S. epidermidis (MIC 2.5-10 uM), E. faecalis (MIC 20 um), A. baumannii (10-20 uM), S. maltophilia (10-40 uM), E. coli (80 uM), P. aeruginosa (80 u
Evidence 8 Activity

Activity

MIC
Antifungal
80 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

mannii (10-20 uM), S. maltophilia (10-40 uM), E. coli (80 uM), P. aeruginosa (80 uM), and C. albicans (MIC 80 uM). Toxic effects on cancer and normal cells: The peptide is also active against select canc
Evidence 9 Activity

Activity

LC50
Hemolysis
6.2
Human erythrocytes: LC50=6.2±1.0 µM

Target

Human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Regul Pept. 2014 Nov 194-195:69-76.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 10 Activity

Activity

50% Cell death
Toxicity
68±2 µM
Cytotoxic
50% Cell death | 68±2 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Anti-cancer, immunoregulatory, and antimicrobial activities of the frog skin host-defense peptides pseudhymenochirin-1Pb and pseudhymenochirin-2Pa. | Regul Pept | 2014
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
6.2±1.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 6.2±1.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-cancer, immunoregulatory, and antimicrobial activities of the frog skin host-defense peptides pseudhymenochirin-1Pb and pseudhymenochirin-2Pa. | Regul Pept | 2014
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
7±2 µM
Hemolytic Cytotoxic
50% Hemolysis | 7±2 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Conformational Analysis of the Host-Defense Peptides Pseudhymenochirin-1Pb and -2Pa and Design of Analogues with Insulin-Releasing Activities and Reduced Toxicities. | J Nat Prod | 2015
Evidence 13 Activity

Activity

LC50
Toxicity
6.2
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: LC50=6.2±1.0 µM | Cytotoxicity: HUVEC: LC50=68±2 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Regul Pept. 2014 Nov 194-195:69-76.
Evidence 14 Hemolysis

Activity

6.2
LC50
Human erythrocytes: LC50=6.2±1.0 µM
Hemolysis

Target

Human erythrocytes

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Regul Pept. 2014 Nov 194-195:69-76.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.